| 1. |
- Rasmussen, Morten, et al.
(författare)
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Ancient human genome sequence of an extinct Palaeo-Eskimo
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 463:7282, s. 757-762
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Tidskriftsartikel (refereegranskat)abstract
- We report here the genome sequence of an ancient human. Obtained from ∼4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit.
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| 2. |
- Ellis, A. D., et al.
(författare)
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Future Directions to Realize Ultra-High Bit-Rate Transmission Systems
- 2010
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Ingår i: Proceedings of OptoElectronics and Communications Conference, OECC 2010, Sapporo, Japan, 5-9 July 2010, invited paper..
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In this paper we examine two potential future directions for the realization of ultra-high bit rate transmission systems.
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| 3. |
- Slavík, Radan, et al.
(författare)
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All-optical phase and amplitude regenerator for next-generation telecommunications systems
- 2010
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Ingår i: Nature Photonics. - 1749-4885 .- 1749-4893. ; 4:10, s. 690-695
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Tidskriftsartikel (refereegranskat)abstract
- Fibre-optic communications systems have traditionally carried data using binary (on-off) encoding of the light amplitude. However, next-generation systems will use both the amplitude and phase of the optical carrier to achieve higher spectral efficiencies and thus higher overall data capacities. Although this approach requires highly complex transmitters and receivers, the increased capacity and many further practical benefits that accrue from a full knowledge of the amplitude and phase of the optical field more than outweigh this additional hardware complexity and can greatly simplify optical network design. However, use of the complex optical field gives rise to a new dominant limitation to system performance—nonlinear phase noise. Developing a device to remove this noise is therefore of great technical importance. Here, we report the development of the first practical (‘black-box’) all-optical regenerator capableof removing both phase and amplitude noise from binary phase-encoded optical communications signals.
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| 4. |
- Kaspersen, Jørn D., et al.
(författare)
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Generic structures of cytotoxic liprotides : nano-sized complexes with oleic acid cores and shells of disordered proteins
- 2014
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Ingår i: ChemBioChem. - : Wiley-VCH Verlagsgesellschaft. - 1439-4227 .- 1439-7633. ; 15:18, s. 2693-2702
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Tidskriftsartikel (refereegranskat)abstract
- The cytotoxic complex formed between alpha-lactalbumin and oleic acid (OA) has inspired many studies on protein-fatty acid complexes, but structural insight remains sparse. After having used small-angle X-ray scattering (SAXS) to obtain structural information, we present a new, generic structural model of cytotoxic protein-oleic acid complexes, which we have termed liprotides (lipids and partially denatured proteins). Twelve liprotides formed from seven structurally unrelated proteins and prepared by different procedures all displayed core-shell structures, each with a micellar OA core and a shell consisting of flexible, partially unfolded protein, which stabilizes the OA micelle. The common structure explains similar effects exerted on cells by different liprotides and is consistent with a cargo off-loading of the OA into cell membranes.
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