| 1. |
- Blomquist, Tomas, 1963-, et al.
(författare)
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Project-as-practice : in search of project management research that matters
- 2010
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Ingår i: Project Management Journal. - : SAGE Publications. - 8756-9728 .- 1938-9507. ; 41:1, s. 5-16
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Tidskriftsartikel (refereegranskat)abstract
- Research on projects is not only an immaturefield of research, but it is also insubstantial whenit comes to understanding what occurs in projects.This article contributes to making projectmanagement research matter to the academic aswell as to the practitioner by developing a projectas-practice approach, in alignment with theongoing debate in social science research.The article outlines a framework and argues thatthere are two major challenges to the researcherand also suggests how these challenges can bemet. Underlying notions of the practice approachare outlined to ensure a development of theproject-as-practice approach that makes projectmanagement research matter!
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| 2. |
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| 3. |
- Gad, Helge, et al.
(författare)
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
- 2014
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221
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Tidskriftsartikel (refereegranskat)abstract
- Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
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| 4. |
- Hällgren, Markus, et al.
(författare)
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Relevance lost! a critical review of project management standardisation
- 2012
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Ingår i: International Journal of Managing Projects in Business. - : Emerald Group Publishing Limited. - 1753-8378 .- 1753-8386. ; 5:3, s. 457-485
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The purpose of this paper is to critically analyze the consequences of the diffusion of generic project management knowledge.Design/methodology/approach: This paper is conceptual in its nature, using short examples of four different areas (education, research, certification and practice) to show the diffusion of project management knowledge throughout these areas.Findings: In this paper the authors argue that relevance may be lost at two levels. The first loss occurs when the practice of project management is transferred, through generalisation and standardisation, into what is generally known as “Best Practice”. The second occurs when “Best Practice” is transferred back to where it is applied (education, research, certification and practice).Research limitations/implications: The risk of losing relevance has consequences for what one bases one's assumptions of the nature of projects upon. If the assumptions are based on standardized knowledge, without critically assessing its correctness, the likelihood of producing less relevant research is higher.Practical implications: With the risk of losing relevance the authors argue that anyone involved in the areas of education, research, certification and practice needs to be cautious of how they perceive and work with the standards. There is a risk that the knowledge becomes even less relevant and students and practitioners are therefore less prepared for reality.Originality/value: This paper is part of the literature critiquing the standardization of project management knowledge but it is distinct in terms of how the diffusion processes are perceived and utilized in a project setting.
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| 5. |
- Nilsson, Andreas, 1971-, et al.
(författare)
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Reflections on Barry W. Boehm's "A spiral model of software development and enhancement"
- 2012
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Ingår i: International Journal of Managing Projects in Business. - : Emerald Group Publishing Limited. - 1753-8378 .- 1753-8386. ; 5:4, s. 737-756
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Forskningsöversikt (refereegranskat)abstract
- Purpose: The purpose of this paper is to review the content, contributions and subsequent developments of the seminal paper by Barry Boehm, “A spiral model of software development and enhancement” written in 1988. The relationships of this paper to software development, agile projects, real options and present practice are put into perspective.Design/methodology/approach: Basically an essayist approach is taken. First, the contents of Boehm's paper are reviewed and then associated with subsequent developments.Findings: Review of the paper as published represents a documentation of cutting‐edge software development as it existed at the time. Fundamentally it suggests the viability of a non‐linear, customer‐influenced, development approach.Practical implications: This basic approach illustrated in the spiral model of course has found its way into complex project approaches and management.Originality/value: This paper follows the lines of increasing attention to classics, which is the purpose of this special issue of the journal. In particular, attention is called to the transition of thought on projects and project management from supplier‐oriented, linear processes to customer/client‐influenced, non‐linear ones.
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