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Träfflista för sökning "WFRF:(Nilsson Ekdahl Kristina) srt2:(1995-1999)"

Sökning: WFRF:(Nilsson Ekdahl Kristina) > (1995-1999)

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  • Hong, Jaan, et al. (författare)
  • A new in vitro model to study interaction between whole blood and biomaterials. Studies of platelet and coagulation activation and the effect of aspirin
  • 1999
  • Ingår i: Biomaterials. - : Elsevier. - 0142-9612 .- 1878-5905. ; 20:7, s. 603-611
  • Tidskriftsartikel (refereegranskat)abstract
    • We have developed a versatile in vitro chamber model with a double purpose: first, to be able to study mechanisms of bio- incompatibility, and, second, to test biomaterials at all levels of interactions, in whole blood. The use of biomaterials in the form of microscope slides as walls in the chamber makes it possible to analyse both the biomaterial surface with regard to protein and cell binding, as well as the molecular events taking place in the fluid. Incubation of blood in the chamber, for 60 min at 37°C resulted in the rapid binding of complement and coagulation proteins and of leukocytes and platelets to polyvinylchloride (PVC) slides. The cells formed a layer which more or less covered the underlying surface. Unlike complement activation, as reflected by soluble C3a and C5b-9, the thrombin—antithrombin formation was completely nullified in cell-depleted plasma. Despite the fact that throm- bin—antithrombin generation was also negligible in platelet-rich plasma, inhibition of platelet aggregation on the material surface with aspirin resulted in suppressed generation of thrombin—antithrombin complexes. Taken together, the coagulation activation in the chamber was dependent on the presence of blood cells which suggests that bound/aggregated platelets initiate a sequence of events involving leukocytes that results in coagulation activation. 
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  • Nilsson, Bo, et al. (författare)
  • Components of the alternative pathway
  • 1998. - 2
  • Ingår i: The complement system. - : Springer. - 3540618945 ; , s. 23-49
  • Bokkapitel (refereegranskat)abstract
    • Its key role in life preserving functions such as host defense against infections or inflammatory reactions has put the serum complement system at the forefront of biomedical research in both the laboratory and the clinic. This book describes the basic regulation of the complement systems, presenting its biological functions, the target cell receptors for such functions and their interactions with ligands to induce specific cellular responses. The biological functions are also discussed in the context of more complex conditions, for example in host defense, chronic inflammatory disease, graft rejection as well as in adverse reactions to drugs or to artificial surfaces. The book offers the present state-of-the-art compiled by leading experts in the field. Extensive literature citations offer easy access to those interested in more detail.
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  • Nilsson, Bo, et al. (författare)
  • Components of the alternative pathway.
  • 1998
  • Ingår i: The complement system. - : Springer Verlag. ; , s. 23-
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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  • Resultat 1-10 av 21

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