| 1. |
- Göransson, Jenny, 1978-, et al.
(författare)
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A single molecule array for digital targeted molecular analyses
- 2009
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Ingår i: Nucleic Acids Research. - England : Oxford University Press. - 0305-1048 .- 1362-4962. ; 37:1, s. e7-
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Tidskriftsartikel (refereegranskat)abstract
- We present a new random array format together with a decoding scheme for targeted multiplex digital molecular analyses. DNA samples are analyzed using multiplex sets of padlock or selector probes that create circular DNA molecules upon target recognition. The circularized DNA molecules are amplified through rolling-circle amplification (RCA) to generate amplified single molecules (ASMs). A random array is generated by immobilizing all ASMs on a microscopy glass slide. The ASMs are identified and counted through serial hybridizations of small sets of tag probes, according to a combinatorial decoding scheme. We show that random array format permits at least 10 iterations of hybridization, imaging and dehybridization, a process required for the combinatorial decoding scheme. We further investigated the quantitative dynamic range and precision of the random array format. Finally, as a demonstration, the decoding scheme was applied for multiplex quantitative analysis of genomic loci in samples having verified copy-number variations. Of 31 analyzed loci, all but one were correctly identified and responded according to the known copy-number variations. The decoding strategy is generic in that the target can be any biomolecule which has been encoded into a DNA circle via a molecular probing reaction.
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| 2. |
- Belova, E., et al.
(författare)
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The dynamical background of polar mesosphere winter echoes from simultaneous EISCAT and ESRAD observations
- 2005
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Ingår i: Annales Geophysicae. - : European Geosciences Union. - 0992-7689 .- 1432-0576. ; 23:4, s. 1239-1247
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Tidskriftsartikel (refereegranskat)abstract
- On 30 October 2004 during a strong solar proton event, layers of enhanced backscatter from altitudes between 55 and 75km have been observed by both ESRAD (52MHz) and the EISCAT VHF (224MHz) radars. These echoes have earlier been termed Polar Mesosphere Winter Echoes, PMWE. After considering the morphology of the layers and their relation to observed atmospheric waves, we conclude that the radars have likely seen the same phenomenon even though the radars' scattering volumes are located about 220km apart and that the most long-lasting layer is likely associated with wind-shear in an inertio-gravity wave. An ion-chemistry model is used to determine parameters necessary to relate wind-shear induced turbulent energy dissipation rates to radar backscatter. The model is verified by comparison with electron density profiles measured by the EISCAT VHF radar. Observed radar signal strengths are found to be 2-3 orders of magnitude stronger than the maximum which can be expected from neutral turbulence alone, assuming that previously published results relating radar signal scatter to turbulence parameters, and turbulence parameters to wind shear, are correct. The possibility remains that some additional or alternative mechanism may be involved in producing PMWE, such as layers of charged dust/smoke particles or large cluster ions.
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| 3. |
- Nilsson, Jonas, 1978-
(författare)
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Investment with a conscience : Examining the impact of pro-social attitudes and perceived financial performance on socially responsible investment behavior
- 2008
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Ingår i: Journal of Business Ethics. - : Springer. - 0167-4544 .- 1573-0697. ; 83:2, s. 307-325
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Tidskriftsartikel (refereegranskat)abstract
- This article addresses the growing industry of retail socially responsible investment (SRI) profiled mutual funds. Very few previous studies have examined the final consumer of SRI profiled mutual funds. Therefore, the purpose of this study was to, in an exploratory manner, examine the impact of a number of pro-social, financial performance, and socio-demographic variables on SRI behavior in order to explain why investors choose to invest different proportions of their investment portfolio in SRI profiled funds. An ordinal logistic regression analysis on 528 private investors revealed that two of the three pro-social variables had a positive impact on how much the consumer invested in SRI profiled funds. Moreover, there was proof of a non-altruistic motive for investing in SRI as consumers who perceive that financial return of SRI is equal or better than “regular” mutual funds, invested a greater proportion of their portfolio in SRI profiled mutual funds. Furthermore, the results showed that women and better-educated investors were more likely to invest a greater proportion of their investment portfolio in SRI. Overall, the findings indicate that both financial perceptions and pro-social attitudes are connected to consumer investment in SRI.
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| 4. |
- Nilsson, Jonas, 1978-
(författare)
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Segmenting socially responsible investors : The influence of financial return and social responsibility
- 2009
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Ingår i: International Journal of Bank Marketing. - : Emerald Group Publishing Limited. - 0265-2323 .- 1758-5937. ; 27:1, s. 5-31
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Tidskriftsartikel (refereegranskat)abstract
- Purpose – This article address reasons for consumer investment in socially responsible investment (SRI) profiled mutual funds. Specifically, the paper deals with the relative influence of financial return and social responsibility on the decision to invest in SRI profiled mutual funds. Methodology/approach - A cluster analytic approach was used where 563 SR-investors were classified into different segments based on their perception of importance of financial return and social responsibility. Furthermore, discriminant analysis and chi2 tests were used to profile the segments. Findings - Three segments of SR-investors were formed. The “primarily concerned about profit” SR-investors value financial return over social responsibility. The “primarily concerned about social responsibility” value social responsibility over financial return. The “socially responsible & return driven” SR-investors value both return and social responsibility when deciding to invest in SRI. The segments displayed distinct differences with regard to various profiling variables. Research limitations/implications – As respondents were generated from one SRI provider, it is possible that the respondents are not fully representative of all SR-investors. Practical implications - Since there are segments of SR-investors that invest in SRI because of different reasons, there is an opportunity for SRI providers to target and adapt communication to certain segments. Originality/value - For both academia and the SRI industry this study provides useful knowledge on how private SR-investors handle the issue of financial return and social responsibility when investing in SRI. This understanding of the differing motivations of the SR-investor also holds practical importance for developing appropriate marketing strategies within the SRI industry.
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| 5. |
- Nilsson, Jonas, 1978
(författare)
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Segmenting socially responsible mutual fund investors: The influence of financial return and social responsibility
- 2009
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Ingår i: International Journal of Bank Marketing. - : Emerald. - 0265-2323. ; 27, s. 5-31
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Tidskriftsartikel (refereegranskat)abstract
- Purpose – The purpose of this paper is to address reasons for consumer investment in socially responsible investment (SRI) profiled mutual funds. Specifically, the paper deals with the relative influence of financial return and social responsibility on the decision to invest in SRI profiled mutual funds. Design/methodology/approach – A cluster analytic approach was used where 563 SR-investors were classified into different segments based on their perception of importance of financial return and social responsibility. Furthermore, discriminant analysis and chi2 tests were used to profile the segments. Findings – Three segments of SR-investors were formed. The “primarily concerned about profit” SR-investors value financial return over social responsibility. The “primarily concerned about social responsibility” value social responsibility over financial return. The “socially responsible and return driven” SR-investors value both return and social responsibility when deciding to invest in SRI. The segments displayed distinct differences with regard to various profiling variables. Research limitations/implications – As respondents were generated from one SRI provider, it is possible that the respondents are not fully representative of all SR-investors. Practical implications – Since there are segments of SR-investors that invest in SRI because of different reasons, there is an opportunity for SRI providers to target and adapt communication to certain segments. Originality/value – For both academia and the SRI industry this study provides useful knowledge on how private SR-investors handle the issue of financial return and social responsibility when investing in SRI. This understanding of the differing motivations of the SR-investor also holds practical importance for developing appropriate marketing strategies within the SRI industry. © 2009, Emerald Group Publishing Limited
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