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- Forsberg-Nilsson, Karin, et al.
(författare)
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Oligodendrocyte precursor hypercellularity and abnormal retina development in mice overexpressing PDGF-B in myelinating tracts
- 2003
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Ingår i: Glia. - : Wiley. - 0894-1491 .- 1098-1136. ; 41:3, s. 276-89
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Tidskriftsartikel (refereegranskat)abstract
- Platelet-derived growth factor (PDGF) influences the generation of neurons and glia during embryogenesis and in early postnatal life. In an attempt to determine the consequences of an overexpression of PDGF-B during the first weeks of life, we targeted transgenic expression of a human PDGF-B cDNA to myelinating tracts using the promoter region of the myelin basic protein (MBP) gene. Transgenic mRNA and protein were expressed in the brain and the expression profile of the human PDGF-B during early postnatal development closely paralleled that of the endogenous mouse MBP gene. The gross morphological appearance of transgenic brains was normal but at the cellular level several phenotypic alterations could be identified. In white matter tracts such as the corpus callosum and cerebellar medulla, there was a marked hypercellularity. The number of oligodendrocyte precursors was increased and astrocytes were more abundant. In adult mice carrying the MBP-PDGF-B transgene, however, myelination appeared normal and the amount of oligodendrocytes was similar to that of control littermates. In addition to the phenotypic alterations in the brain, investigation of eye structure revealed a striking disorganization of retinal architecture. The retina was folded with cells collected in papillar or follicular-like structures. Retinal whole mount preparations after India ink perfusion revealed capillary disorganization with large-caliber vessels supporting only a few fine branches. Our observations strengthen the notion that PDGF is an important effector molecule in postnatal CNS development.
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- Solem, Kristian, et al.
(författare)
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Detection of hypotension during hemodialysis using the ECG
- 2004
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Ingår i: [Host publication title missing]. - 0780389271 ; 31, s. 717-720
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Konferensbidrag (refereegranskat)abstract
- There is today a lack of clinical techniques for detecting acute hypotension during conventional hemodialysis treat -ment, despite the fact that hypotension remains the - mosr common acute complication during hemodialysis. Hypotension is often followed by nausea, vomiting, and even fainting, not only strenuous for the patient but requires considerable attention from the nursing staf. The problem of detecting hypotension was studied by means of a multimodal database. The database consists of 30 treatments in which each treatment includes several simultaneously acquired signals. Acute .symptomatic hypotension occurred in 2 of the 30 treatments. An ECG-based method for detecting hypotension has been developed. n e method involves information on heart rate variability (HRV) and ectopic beat patterns. The proposed method does not only detect the two cases of acute hypotension but also provides information of the patient's propensity to hypotension at an early stage of hemodialysis.
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