| 1. |
- Antonsson, H, et al.
(författare)
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VIBRATIONAL MOTION AND GEOMETRICAL STRUCTURE IN ADSORBED CO STUDIED BY CORE LEVEL PHOTOELECTRON-SPECTROSCOPY
- 1990
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Ingår i: Journal of Electron Spectroscopy and Related Phenomena. - 0368-2048. ; 54, s. 601-613
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Tidskriftsartikel (refereegranskat)abstract
- High resolution core level spectra from CO adsorbed on clean and hydrogen precovered Ni(100) and CO adsorbed on Cu(100) are presented. The core level binding energy is shown to be sensitive to the adsorption site. Cluster calculations reproduce the general trend of the binding energy shifts between the on top and hollow sites of CO/Ni(100). In the coadsorption system CO/H/Ni(100) three different adsorption sites have been observed with a maximum binding energy shift of 2.6 eV for the Ols level. The temperature dependence of the Cls and Ols line profiles in CO/Ni(100) has been carefully investigated. The temperature dependent broadening is due to thermal excitations of frustrated translations parallel to the surface. The spectra from CO on Cu(100) show no temperature dependence below 200K.
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| 2. |
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| 3. |
- Letocha, H, et al.
(författare)
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Positron emission tomography with L-methyl-11C-methionine in the monitoring of therapy response in muscle-invasive transitional cell carcinoma of the urinary bladder
- 1994
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Ingår i: British Journal of Urology. - 0007-1331 .- 1365-2176. ; 74:6, s. 767-774
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To investigate whether positron emission tomography (PET) with L-methyl-11C-methionine as a tracer could be used for diagnostic purposes and for evaluation of therapy in patients with varying stages of urinary bladder cancer treated with chemotherapy. PATIENTS AND METHODS: PET was employed in 44 separate examinations involving 29 patients (24 men and five women with a median age of 68 years [mean 66, range 47-78]) with localized or metastatic transitional cell carcinoma of the urinary bladder. In four patients PET examinations were performed prior to the commencement of chemotherapy, and after one course and after three courses. RESULTS: The diagnostic accuracy of PET was poor. The technique did not monitor the therapeutic effect of neoadjuvant chemotherapy, producing results that correlated with therapy outcome. PET identified those patients who responded less successfully to therapy. CONCLUSION: PET with L-methyl-11C-methionine demonstrates alterations in tumour metabolism long before visible changes appear on computed tomography or magnetic resonance imaging. Further work is required to develop more specific tracers.
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| 4. |
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| 5. |
- Nilsson, Per, et al.
(författare)
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A generalized formulation of the 'incomplete-repair' model for cell survival and tissue response to fractionated low dose-rate irradiation
- 1990
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Ingår i: International Journal of Radiation Biology. - : Informa UK Limited. - 0955-3002 .- 1362-3095. ; 57:1, s. 127-142
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Tidskriftsartikel (refereegranskat)abstract
- A generalized equation for cell survival or tissue effects after fractionated low dose-rate irradiations, when there is incomplete repair between fractions and significant repair during fractions, is derived in terms of the h- and g-functions of the 'incomplete-repair' (IR) model. This model was developed originally from the concept of 'dose equivalent of incomplete repair', assuming that the repair of radiation damage is an exponential function of time and that the cell survival curve can be described adequately by the linear quadratic (LQ) formalism. The generalized incomplete-repair equation is shown to be equivalent to an expression derived by Dale et al. (1988) for analysis of tissue effects of fractionated irradiations at varying dose rates. The model is critically dependent on alpha/beta, repair half-time, treatment time and interfraction interval, and should therefore be regarded primarily as a tool for the analysis of fractionation and dose-rate effects in carefully designed radiobiological experiments, although it should also be useful in exploring, in a general way, the feasibility of clinical treatment protocols using fractionated low dose-rate treatments.
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