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- Nordanskog, Pia, et al.
(författare)
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Hippocampal volume in relation to clinical and cognitive outcome after electroconvulsive therapy in depression
- 2014
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Ingår i: Acta Psychiatrica Scandinavica. - United States : Wiley-Blackwell. - 0001-690X .- 1600-0447. ; 129:4, s. 303-311
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE:In a previous magnetic resonance imaging (MRI) study, we found a significant increase in hippocampal volume immediately after electroconvulsive therapy (ECT) in patients with depression. The aim of this study was to evaluate hippocampal volume up to 1 year after ECT and investigate its possible relation to clinical and cognitive outcome.METHOD:Clinical and cognitive outcome in 12 in-patients with depression receiving antidepressive pharmacological treatment referred for ECT were investigated with the Montgomery-Asberg Depression Rating Scale (MADRS) and a broad neuropsychological test battery within 1 week before and after ECT. The assessments were repeated 6 and 12 months after baseline in 10 and seven of these patients, respectively. Hippocampal volumes were measured on all four occasions with 3 Tesla MRI.RESULTS:Hippocampal volume returned to baseline during the follow-up period of 6 months. Neither the significant antidepressant effect nor the significant transient decrease in executive and verbal episodic memory tests after ECT could be related to changes in hippocampal volume. No persistent cognitive side effects were observed 1 year after ECT.CONCLUSION:The immediate increase in hippocampal volume after ECT is reversible and is not related to clinical or cognitive outcome.
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| 2. |
- Nordanskog, Pia, et al.
(författare)
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Increase in Hippocampal Volume After Electroconvulsive Therapy in Patients With Depression : A Volumetric Magnetic Resonance Imaging Study
- 2010
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Ingår i: JOURNAL OF ECT. - 1095-0680 .- 1533-4112. ; 26:1, s. 62-67
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Tidskriftsartikel (refereegranskat)abstract
- Background: Major depression has traditionally been regarded as a neurochemical disease, but findings of a decreased hippocampal volume in patients with depression have turned the pathophysiological focus toward impairments in structural plasticity. The mechanisms of action of the most effective antidepressive treatment, electroconvulsive therapy (ECT), still remains elusive, but recent animal research has provided evidence for a cell proliferative effect in the hippocampus. The aim of this prospective study was to determine if hippocampal volume changes after ECT in patients with depression.Methods: Twelve patients with depression and ongoing antidepressive pharmacological treatment were investigated with clinical ratings and 3 T magnetic resonance imaging within 1 week before and after the ECT series. Each hippocampus was manually outlined on coronal slices, and the volume was calculated.Results: The left as well as the right hippocampal volume increased significantly after ECT.Conclusions: The hippocampal volume increases after ECT, supporting the hypothesis that hippocampus may play a central role in the treatment of depression.
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| 3. |
- Nordensköld, Axel, et al.
(författare)
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ECT: Kliniska riktlinjer för elektrokonvulsiv behandling
- 2014. - 1
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Bok (populärvet., debatt m.m.)abstract
- Mycket svåra psykiska sjukdomar medför stort lidande, sänker individens funktionsnivå påtagligt och påverkar anhöriga i hög grad. Obehandlade kan de i värsta fall leda till döden. Korrekt administrerad och på välvalda indikationer är elektrokonvulsiv terapi (ECT) en säker och effektiv behandling vid flera av dessa sjukdomar.Svenska Psykiatriska Föreningen har tagit initiativ till att skapa kliniska riktlinjer för ECT. Ambitionen är att tillhandahålla aktuell kunskap inom hela ECT-området och att vara ett stöd i användning och uppföljning av ECT. I riktlinjerna föreslås kvalitetsindikatorer som med stöd av kvalitetsregistret för ECT kan användas för att utveckla den egna verksamheten.Riktlinjerna vänder sig till behandlingsansvariga läkare, verksamhetschefer och till övrig personal inom psykiatrin i Sverige.Svenska Psykiatriska Föreningen har sedan 1996 utformat kliniska riktlinjer för en rad psykiatriska områden. ECT - kliniska riktlinjer för elektrokonvulsiv behandling är den femtonde skriften i serien Svensk Psykiatri.
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