| 1. |
- Bayford, Richard H., et al.
(författare)
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Locating Functionalized Gold Nanoparticles Using Electrical Impedance Tomography
- 2022
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Ingår i: IEEE Transactions on Biomedical Engineering. - : IEEE. - 0018-9294 .- 1558-2531. ; 69:1, s. 494-502
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Tidskriftsartikel (refereegranskat)abstract
- Objective: An imaging device to locate functionalised nanoparticles, whereby therapeutic agents are transported from the site of administration specifically to diseased tissues, remains a challenge for pharmaceutical research. Here, we show a new method based on electrical impedance tomography (EIT) to provide images of the location of gold nanoparticles (GNPs) and the excitation of GNPs with radio frequencies (RF) to change impedance permitting an estimation of their location in cell models Methods: We have created an imaging system using quantum cluster GNPs as contrast agent, activated with RF fields to heat the functionalized GNPs, which causes a change in impedance in the surrounding region. This change is then identified with EIT. Results: Images of impedance changes of around 80 ± 4% are obtained for a sample of citrate stabilized GNPs in a solution of phosphate-buffered saline. A second quantification was carried out using colorectal cancer cells incubated with culture media, and the internalization of GNPs into the colorectal cancer cells was undertaken to compare them with the EIT images. When the cells were incubated with functionalised GNPs, the change was more apparent, approximately 40 ± 2%. This change was reflected in the EIT image as the cell area was more clearly identifiable from the rest of the area. Significance: EIT can be used as a new method to locate functionalized GNPs in human cells and help in the development of GNP-based drugs in humans to improve their efficacy in the future.
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| 2. |
- Bayford, Richard H., et al.
(författare)
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Locating Functionalized Gold Nanoparticles Using Electrical Impedance Tomography
- 2022
-
Ingår i: IEEE Transactions on Biomedical Engineering. - : IEEE. - 0018-9294 .- 1558-2531. ; 69:1, s. 494-502
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: An imaging device to locate functionalised nanoparticles, whereby therapeutic agents are transported from the site of administration specifically to diseased tissues, remains a challenge for pharmaceutical research. Here, we show a new method based on electrical impedance tomography (EIT) to provide images of the location of gold nanoparticles (GNPs) and the excitation of GNPs with radio frequencies (RF) to change impedance permitting an estimation of their location in cell models Methods: We have created an imaging system using quantum cluster GNPs as contrast agent, activated with RF fields to heat the functionalized GNPs, which causes a change in impedance in the surrounding region. This change is then identified with EIT. Results: Images of impedance changes of around 80 +/- 4% are obtained for a sample of citrate stabilized GNPs in a solution of phosphate-buffered saline. A second quantification was carried out using colorectal cancer cells incubated with culture media, and the internalization of GNPs into the colorectal cancer cells was undertaken to compare them with the EIT images. When the cells were incubated with functionalised GNPs, the change was more apparent, approximately 40 +/- 2%. This change was reflected in the EIT image as the cell area was more clearly identifiable from the rest of the area. Significance: EIT can be used as a new method to locate functionalized GNPs in human cells and help in the development of GNP-based drugs in humans to improve their efficacy in the future.
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| 3. |
- Becher, Tobias H., et al.
(författare)
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Prolonged Continuous Monitoring of Regional Lung Function in Infants with Respiratory Failure
- 2022
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Ingår i: Annals of the American Thoracic Society. - : American Thoracic Society. - 2329-6933 .- 2325-6621. ; 19:6, s. 991-999
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: Electrical impedance tomography (EIT) allows instantaneous and continuous visualization of regional ventilation and changes in end-expiratory lung volume at the bedside. There is particular interest in using EIT for monitoring in critically ill neonates and young children with respiratory failure. Previous studies have focused only on short-term monitoring in small populations. The feasibility and safety of prolonged monitoring with EIT in neonates and young children have not been demonstrated yet.Objectives: To evaluate the feasibility and safety of long-term EIT monitoring in a routine clinical setting and to describe changes in ventilation distribution and homogeneity over time and with positioning in a multicenter cohort of neonates and young children with respiratory failure.Methods: At four European University hospitals, we conducted an observational study (NCT02962505) on 200 patients with postmenstrual ages (PMA) between 25 weeks and 36 months, at risk for or suffering from respiratory failure. Continuous EIT data were obtained using a novel textile 32-electrode interface and recorded at 48 images/s for up to 72 hours. Clinicians were blinded to EIT images during the recording. EIT parameters and the effects of body position on ventilation distribution were analyzed offline. Results: The average duration of FAT measurements was 53 +/- 20 hours. Skin contact impedance was sufficient to allow image reconstruction for valid ventilation analysis during a median of 92% (interquartile range, 77-98%) of examination time. EIT examinations were well tolerated, with minor skin irritations (temporary redness or imprint) occurring in 10% of patients and no moderate or severe adverse events. Higher ventilation amplitude was found in the dorsal and right lung areas when compared with the ventral and left regions, respectively. Prone positioning resulted in an increase in the ventilation-related EIT signal in the dorsal hemithorax, indicating increased ventilation of the dorsal lung areas. Lateral positioning led to a redistribution of ventilation toward the dependent lung in preterm infants and to the nondependent lung in patients with PMA > 37 weeks.Conclusions: EIT allows continuous long-term monitoring of regional lung function in neonates and young children for up to 72 hours with minimal adverse effects. Our study confirmed the presence of posture-dependent changes in ventilation distribution and their dependency on PMA in a large patient cohort.
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| 4. |
- Dalarsson, Mariana, et al.
(författare)
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TE-wave propagation in graded waveguide structures
- 2020
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Ingår i: OSA Continuum. - : Optical Society of America. - 2578-7519. ; 3:1, s. 67-76
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Tidskriftsartikel (refereegranskat)abstract
- We investigate TE-wave propagation in a hollow waveguide with a graded dielectric layer, described using a hyperbolic tangent function. General formulae for the electric field components of the TE-waves, applicable to hollow waveguides with arbitrary cross sectional shapes, are presented. We illustrate the exact analytical results for the electric field components in the special case of a rectangular waveguide. Furthermore, we derive exact analytical results for the reflection and transmission coefficients valid for waveguides of arbitrary cross sectional shapes. Finally, we show that the obtained reflection and transmission coefficients are in exact asymptotic agreement with those obtained for a very thin homogeneous dielectric layer using mode-matching and cascading. The proposed method gives analytical results that are directly applicable without the need of mode-matching, and it has the ability to model realistic, smooth transitions. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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| 5. |
- Dalarsson, Mariana, et al.
(författare)
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TE-wave propagation in graded waveguide structures
- 2020
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Ingår i: OSA Continuum. - : Optica Publishing Group. - 2578-7519. ; 3:1, s. 67-67
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Tidskriftsartikel (refereegranskat)abstract
- We investigate TE-wave propagation in a hollow waveguide with a graded dielectric layer, described using a hyperbolic tangent function. General formulae for the electric field components of the TE-waves, applicable to hollow waveguides with arbitrary cross sectional shapes, are presented. We illustrate the exact analytical results for the electric field components in the special case of a rectangular waveguide. Furthermore, we derive exact analytical results for the reflection and transmission coefficients valid for waveguides of arbitrary cross sectional shapes. Finally, we show that the obtained reflection and transmission coefficients are in exact asymptotic agreement with those obtained for a very thin homogeneous dielectric layer using mode-matching and cascading. The proposed method gives analytical results that are directly applicable without the need of mode-matching, and it has the ability to model realistic, smooth transitions.
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| 6. |
- Dalarsson, Mariana, et al.
(författare)
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Wave propagation in waveguides with graded plasmonic obstacles
- 2021
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Ingår i: Journal of the Optical Society of America. B, Optical physics. - : OPTICAL SOC AMER. - 0740-3224 .- 1520-8540. ; 38:1, s. 104-113
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, wave propagation in a hollow waveguide with a graded dielectric layer is studied. Analytic formulas are derived for the electric field components as well as general analytical results for the reflection and transmission coefficients for propagating waves. These results are all valid for waveguides of arbitrary cross sections, and the derived reflection and transmission coefficients are in exact asymptotic agreement with those obtained for a wry thin homogeneous dielectric layer using cascading and mode-matching techniques. Furthermore, the power transmission, reflection, and absorption coefficients, as functions of frequency and layer width, are studied, showing the expected behavior of these parameters. The method proposed in this paper gives directly applicable results that do not require cascading and mode matching, while at the same time having the ability to model smooth transitions that are more realistic in several applications. (C) 2020 Optical Society of America
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| 7. |
- Ivanenko, Yevhen, et al.
(författare)
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Quasi-Herglotz functions and convex optimization
- 2020
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Ingår i: Royal Society Open Science. - : The Royal Society Publishing. - 2054-5703. ; 7:1, s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- We introduce the set of quasi-Herglotz functions and demonstrate that it has properties useful in the modelling of non-passive systems. The linear space of quasi-Herglotz functions constitutes a natural extension of the convex cone of Herglotz functions. It consists of differences of Herglotz functions and we show that several of the important properties and modelling perspectives are inherited by the new set of quasi-Herglotz functions. In particular, this applies to their integral representations, the associated integral identities or sum rules (with adequate additional assumptions), their boundary values on the real axis and the associated approximation theory. Numerical examples are included to demonstrate the modelling of a non-passive gain medium formulated as a convex optimization problem, where the generating measure is modelled by using a finite expansion of B-splines and point masses.
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| 8. |
- Mirmoosa, Mohammad, et al.
(författare)
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Physical Meaning of the Dipole Radiation Resistance in Lossless and Lossy Media : What is the Radiation Resistance of Antennas in Lossy Media?
- 2020
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Ingår i: IEEE Antennas & Propagation Magazine. - : IEEE. - 1045-9243 .- 1558-4143. ; 62:4, s. 75-81
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Tidskriftsartikel (refereegranskat)abstract
- In this tutorial, we discuss the radiation from a Hertzian dipole into uniform isotropic lossy media of infinite extent. If the medium is lossless, the radiated power propagates to infinity, and the apparent dissipation is measured by the radiation resistance of the dipole. If the medium is lossy, the power exponentially decays, and the physical meaning of radiation resistance needs clarification. Here, we present explicit calculations of the power absorbed in the infinite lossy host space and discuss the limit of zero losses. We show that the input impedance of dipole antennas contains a radiation-resistance contribution that does not depend on the imaginary part of the refractive index. This means that the power delivered by dipole antennas to surrounding space always contains a contribution from far fields unless the real part of the refractive index is zero. Based on this understanding, we discuss the fundamental limitations of power coupling between two antennas and possibilities of removing the limit imposed by radiation damping.
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| 9. |
- Nedic, Mitja, et al.
(författare)
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Herglotz functions and applications in electromagnetics
- 2020
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Ingår i: Advances in Mathematical Methods for Electromagnetics. - : Institution of Engineering and Technology. - 9781785613845 - 9781785613852 ; , s. 491-514
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Herglotz functions inevitably appear in pure mathematics, mathematical physics, and engineering with a wide range of applications. In particular, they are the pertinent functions to model passive systems, and thus appear in modeling of electromagnetic phenomena in circuits, antennas, materials, and scattering. In this chapter, we review the basic theory of Herglotz functions and its applications to determine sum rules and physical bounds for passive systems.
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| 10. |
- Nordebo, Sven, 1963-
(författare)
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A modified projection approach to line mixing
- 2023
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Ingår i: Journal of Quantitative Spectroscopy and Radiative Transfer. - : Elsevier. - 0022-4073 .- 1879-1352. ; 310
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a simple approach to combine the high-resolution narrowband features of some desired isolated line models together with the far wing behavior of the projection based strong collision (SC) method to line mixing which was introduced by Bulanin, Dokuchaev, Tonkov and Filippov. The method can be viewed in terms of a small diagonal perturbation of the SC relaxation matrix providing the required narrowband accuracy close to the line centers at the same time as the SC line coupling transfer rates are retained and can be optimally scaled to thermalize the radiator after impact. The method can conveniently be placed in the framework of the Boltzmann–Liouville transport equation where a rigorous diagonalization of the line mixing problem requires that molecular phase and velocity changes are assumed to be uncorrelated. A detailed analysis for the general Doppler case is given based on the first order Rosenkranz approximation, and which also provides the possibility to incorporate quadratically speed dependent parameters. Exact solutions for pure pressure broadening and explicit Rosenkranz approximations are given in the case with velocity independent parameters (line frequency, strength, width and shift) which can readily be retrieved from databases such as HITRAN for a large number of species. Numerical examples including comparisons to published measured data are provided in two specific cases concerning the absorption of carbon dioxide in its infrared band of asymmetric stretching, as well as of atmospheric water vapor and oxygen in relevant millimeter bands.
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