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- Bellner, Lars, 1973, et al.
(författare)
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Characterization of T-cell reactive epitopes in glycoprotein G of herpes simplex virus type 2 using synthetic peptides.
- 2005
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Ingår i: Archives of virology. - : Springer Science and Business Media LLC. - 0304-8608 .- 1432-8798. ; 150:7, s. 1393-406
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Tidskriftsartikel (refereegranskat)abstract
- We have previously shown that the CD4+ T-cell response to herpes simplex virus type 2 glycoprotein G-2 is type-specific and can thus be used to evaluate herpes simplex virus type 2-specific T-cell responses in individuals with a concomitant herpes simplex virus type 1 infection. In this study we have followed the glycoprotein G-2-specific T-cell responses over time, and also tried to identify T-cell epitopes in the membrane bound portion and the secreted portion of glycoprotein G-2 using synthetic peptides spanning the whole amino acid sequence of glycoprotein G-2. We found that the magnitude of the glycoprotein G-2-specific response varied considerably in infected individuals over time, even though all patients responded to at least one of the two glycoproteins at all time-points examined. We could also document strong T-cell responses to synthetic peptides from the secreted glycoprotein G-2 but only low responses to synthetic peptides corresponding to sequences from the heavily glycosylated membrane-bound glycoprotein G-2. We were able to map an immunogenic region (amino acid 31-125) within the secreted glycoprotein G-2. This region of the glycoprotein induced proliferative responses in 47% of the herpes simplex virus type 2-infected individuals. However, we were not able to identify any universal T-cell epitope.
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| 3. |
- Bood, Sven-Åke
(författare)
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Bending and Mending the Neurosignature : Elicting the Relaxation Response with help of Flotation-REST ( Restricted Environmental Stimulation Technique) in Patients with Stress Related Pain
- 2006
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Abstract. The overarching purpose of the current thesis was to assess the long term effects of a documented treatment program involving flotation-REST for the experience of pain, from the point of view of variables connected with Melzack´s neuromatrix theory, and to examine the extent of a potential attention-placebo effect in connection with flotation-REST. Two studies were conducted. The first (Paper I) aimed to investigate long-term effects of flotation-REST four months after treatment. Seventy patients participated, diagnosed as having stress-related pain. Participants were randomly assigned in equal numbers to either a control group or a flotation-REST group and participated in a total of twelve flotation REST or control sessions. Results indicated that pain areas, stress, anxiety and depression decreased, while sleep quality, optimism, and prolactin increased. Positive effects generally maintained four months after treatment. The second (Paper II) examined the potential effects of attention-placebo on flotation tank therapy. Thirty-two patients who were diagnosed as having stress-related muscular pain was treated with flotation- REST for a period of six weeks. Half of the patients were also given attention for a period of 12 weeks, while the remainder received such attention for 6 weeks. Participants in both groups exhibited lowered blood pressure, reduced pain, anxiety, depression, stress, and negative affectivity, as well as increased optimism, energy, and positive affectivity. It was therefore concluded that flotation tank therapy is an effective method for the treatment of stress-related pain.
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- Bood, Sven Åke, 1950-
(författare)
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Bending and Mending the Neurosignature : Frameworks of influence by flotation-REST (Restricted Environmental Stimulation Technique) upon well-being in patients with stress related ailments
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overarching purpose of the current thesis was to assess the long term effects of a treatment program involving flotation-REST for the experience of pain, from the point of view of variables connected with Melzack´s neuromatrix theory, and to examine the extent of a potential attention-placebo effect in connection with flotation-REST.The first study (Paper I) aimed to investigate long-term effects of flotation-REST four months after treatment. Seventy patients participated, diagnosed as having stress-related pain. Participants were randomly assigned to either a control group or a flotation-REST group and participated in a total of twelve flotation REST or control sessions. Results indicated that pain areas, stress, anxiety and depression decreased, while sleep quality, optimism, and prolactin increased. Positive effects generally maintained four months after treatment. The second (Paper II) examined the potential effects of attention-placebo. Thirty-two patients who were diagnosed as having stress-related muscular pain were treated for a period of six weeks. Half of the patients were also given attention for a period of 12 weeks, while the remainder received attention for 6 weeks. Participants in both groups exhibited lowered blood pressure, reduced pain, anxiety, depression, stress, and negative affectivity, as well as increased optimism, energy, and positive affectivity. The third (Paper III) investigated whether or not 33 flotation sessions were more effective for stress related ailments as compared to 12 sessions. Participants were 37 patients with stress related ailments. Analyzes for subjective pain and psychological variables typically indicated that 12 sessions were enough to get considerably improvements and no further improvements were noticed after 33 sessions. Finally, the fourth study (Paper IV) aimed to examine whether and how the combination of therapy and flotation tank could be used to treat patients with severe stress problems. Two women on long-term sick-leave participated in the study, which was carried out over a period of one year. Four overarching themes were generated: the therapeutic work model, transformation of feelings, self-insight and meaning. These together constituted a “therapeutic circle” which after a while transformed in to a “therapeutic spiral” of increased meaning and enhanced wellbeing.It was therefore concluded that flotation tank therapy is an effective method for the treatment of stress-related pain.
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| 5. |
- Bood, Sven-Åke, et al.
(författare)
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Effects of Flotation REST (Restricted Environmental Stimulation Technique) on Stress Related Muscle Pain : Are 33 flotation sessions more effective as compared to 12 sessions?
- 2007
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Ingår i: Social behavior and personality. - 0301-2212 .- 1179-6391. ; 35:2, s. 143-155
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the study was to investigate whether or not 33 flotation sessions were more effective for stress-related ailments than 12 sessions. Participants were 37 patients, 29 women and 8 men, all diagnosed as having stress-related pain of a muscle tension type. The patients were randomized to one of two conditions: 12 flotation-REST treatments or 33 flotation-REST treatments. Analyses for subjective pain typically indicated that 12 sessions were enough to get considerable improvements and no further improvements were noticed after 33 sessions. A similar pattern was observed concerning the stress-related psychological variables: experienced stress, anxiety, depression, negative affectivity, dispositional optimism, and sleep quality. For blood pressure no effects were observed after 12 sessions, but there was a significant lower level for diastolic blood pressure after 33 sessions. The present study highlighted the importance of finding suitable complementary treatments in order to make further progress after the initial 12 sessions.
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| 9. |
- Karlsson, Per-Åke, et al.
(författare)
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Vad gör de som hjälper de gamla i hemmet? En studie om samverkan och kompetens.
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport är en del i utvecklingen av kunskap kring samverkan inom den kommunala hälso- och sjukvården och de olika yrkesgruppernas arbetsuppgifter, samt yrkesgruppernas uppfattning om varandras kunskaper, kompetens och ansvar. Rapporten bygger på resultaten från en studie inom äldreomsorgen i Sjuhäradsbygden. Syftet med studien var att undersöka hur hjälpen till äldre i praktiken är utformad och vilka som ger denna hjälp, genom att ställa frågor som: Vad gör de som hjälper egentligen? Vilka är de? Vad har de för uppfattning om vad andra gör? Men också frågor som: Hur uppfattar de som får hjälpen denna? Vet de vem som ansvarar för att hjälpen ges? Utgångspunkten är den kommunala äldreomsorgen, den formella äldreomsorgen, och vad som händer där.
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| 10. |
- Nordström, Fredrik, et al.
(författare)
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Determination of the activity of a molecular solute in saturated solution
- 2008
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Ingår i: Journal of Chemical Thermodynamics. - : Elsevier BV. - 0021-9614 .- 1096-3626. ; 40:12, s. 1684-1692
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Tidskriftsartikel (refereegranskat)abstract
- Prediction of the solubility of a solid molecular compound in a solvent, as well as, estimation of the solution activity coefficient from experimental solubility data both require estimation of the activity of the solute in the saturated solution. The activity of the solute in the saturated Solution is often defined using the pure melt at the same temperature as the thermodynamic reference. In chemical engineering literature also the activity of the solid is usually defined on the same reference state. However, far below the melting temperature, the properties of this reference state cannot be determined experimentally, and different simplifications and approximations are normally adopted. In the present work, a novel method is presented to determine the activity of the solute in the saturated solution (=ideal solubility) and the heat capacity difference between the pure supercooled melt and solid. The approach is based on rigorous thermodynamics, using standard experimental thermodynamic data at the melting temperature of the pure compound and solubility measurements in different solvents at various temperatures. The method is illustrated using data for ortho-, meta, and para-hydroxybenzoic acid, salicylamide and paracetamol. The results show that complete neglect of the heat capacity terms may lead to estimations of the activity that are incorrect by a factor of 12. Other commonly used simplifications may lead to estimations that are only one-third of the correct value.
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