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| 2. |
- Bailey, Leslie, et al.
(författare)
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Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle
- 2007
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Ingår i: FEBS Letters. - : Elsevier. - 0014-5793 .- 1873-3468. ; 581:4, s. 587-595
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Tidskriftsartikel (refereegranskat)abstract
- Intracellular parasitism by Chlamydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re-differentiate within the host cell. A type three secretion system (T3SS) has been implicated in this process. We have here identified small molecules of a chemical class of acylated hydrazones of salicylaldehydes that specifically blocks the T3SS of Chlamydia. These compounds also affect the developmental cycle showing that the T3SS has a pivotal role in the pathogenesis of Chlamydia. Our results suggest a previously unexplored avenue for development of novel anti-chlamydial drugs.
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| 3. |
- Beers, Timothy C., et al.
(författare)
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Broadband UBVRCIC photometry of horizontal-branch and metal-poor candidates from the HK and Hamburg/ESO surveys. I.
- 2007
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Ingår i: Astrophysical Journal Supplement Series. - : American Astronomical Society. - 0067-0049 .- 1538-4365. ; 168:1, s. 128-139
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Tidskriftsartikel (refereegranskat)abstract
- We report broadband UBV and/or BVRCIC CCD photometry for a total of 1857 stars in the thick-disk and halo populations of the Galaxy. The majority of our targets were selected as candidate field horizontal-branch or other A-type stars (FHB/ A, N = 576), or candidate low-metallicity stars (N = 1221), from the HK and Hamburg/ESO objective-prism surveys. Similar data for a small number of additional stars from other samples are also reported. These data are being used for several purposes. In the case of the FHB/ A candidates they are used to accurately separate the lower gravity FHB stars from various higher gravity A-type stars, a subsample that includes the so-called blue metal poor stars, halo and thick-disk blue stragglers, main-sequence A-type dwarfs, and Am and Ap stars. These data are also being used to derive photometric distance estimates to high-velocity hydrogen clouds in the Galaxy and for improved measurements of the mass of the Galaxy. Photometric data for the metal-poor candidates are being used to refine estimates of stellar metallicity for objects with available medium-resolution spectroscopy, to obtain distance estimates for kinematic analyses, and to establish initial estimates of effective temperature for analysis of high-resolution spectroscopy of the stars for which this information now exists.
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| 4. |
- Berglin, Lena, et al.
(författare)
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Interaction Design Methods in Fashion Design Teaching
- 2007
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Ingår i: The Nordic Textile Journal 2006-07, p. 26-51. - : University College of Borås. The Swedish School of Textiles.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The expressiveness of use is of focal interest in fashion design, which makes the perspective of act design important in learning/teaching. The objective of the project presented here was to introduce interaction design methods in fashion design teaching to make act design explicit throughout the different stages of the design process in a systematic manner; to develop a general workshop curriculum in experimental fashion design focusing on the expressiveness of wearing and use. A series of test workshops were implemented to provide a foundation for reflection and critical discussions. The main results, motivated by workshop evaluations, consist of theoretical models for a systematic development of workshop exercises in fashion design aesthetics.
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| 6. |
- Grann, Martin, et al.
(författare)
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Methodological development : structured outcome assessment and community risk monitoring (SORM)
- 2005
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Ingår i: International Journal of Law and Psychiatry. - : Elsevier BV. - 0160-2527 .- 1873-6386. ; 28:4, s. 442-456
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes an effort to develop a clinical tool for the continuous monitoring of risk for violence in forensic mental health clients who have left their institutions and who are dwelling in the community on a conditional release basis. The model is called Structured Outcome Assessment and Community Risk Monitoring (SORM). The SORM consists of 30 dynamic factors and each factor in SORM is assessed in two ways: The current absence, presence or partial och intermittent presence of the factors, which is an actuarial (systematized and 'objective') assessment. Secondly, the risk effect, i.e. whether the presence/absence of factors currently increases, decreases or is perceived as unrelated to violence risk, is a clinical (or impressionistic) assessment. Thus, the factors considered via the SORM can be coded as risk factors or protective factors (or as factors unimportant to risk of violence) depending on circumstances that apply in the individual case. Further, the SORM has a built-in module for gathering idiographical information about risk-affecting contextual factors. The use of the SORM and its potential as a risk monitoring instrument is illustrated via preliminary data and case vignettes from an ongoing multicenter project. In this research project, patients leaving any of the 9 participating forensic hospitals in Sweden is assessed at release on a variety of static background factors, and the SORM is then administered every 30 days for 2 years.
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| 7. |
- Helmi, A, et al.
(författare)
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Pieces of the puzzle: ancient substructure in the Galactic disc
- 2006
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 1365-2966 .- 0035-8711. ; 365:4, s. 1309-1323
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Tidskriftsartikel (refereegranskat)abstract
- We search for signatures of past accretion events in the Milky Way in the recently published catalogue by Nordstrom et al., containing accurate spatial and kinematic information as well as metallicities for 13 240 nearby stars. To optimize our strategy, we use numerical simulations and characterize the properties of the debris from disrupted satellites. We find that stars with a common progenitor should show distinct correlations between their orbital parameters; in particular, between the apocentre (A) and pericentre (P), as well as their z-angular momentum (L-z). In the APL space, such stars are expected to cluster around regions of roughly constant eccentricity. The APL space for the Nordstrom catalogue exhibits a wealth of substructure, much of which can be linked to dynamical perturbations induced by spiral arms and the Galactic bar. However, our analysis also reveals a statistically significant excess of stars on orbits of common ( moderate) eccentricity, analogous to the pattern expected for merger debris. Besides being dynamically peculiar, the 274 stars in these substructures have very distinct metallicity and age distributions, providing further evidence of their extragalactic provenance. It is possible to identify three coherent groups among these stars, that, in all likelihood, correspond to the remains of disrupted satellites. The most metal-rich group ([Fe/H] >= -0.45 dex) has 120 stars distributed into two stellar populations of similar to 8 Gyr (33 per cent) and similar to 12 Gyr (67 per cent) of age. The second group with <[Fe/H]> similar to -0.6 dex has 86 stars and shows evidence of three populations of 8 Gyr ( 15 per cent), 12 Gyr (36 per cent) and 16 Gyr (49 per cent) of age. Finally, the third group has 68 stars, with typical metallicity around -0.8 dex and a single age of similar to 14 Gyr. The identification of substantial amounts of debris in the Galactic disc whose origin can be traced back to more than one satellite galaxy, provides evidence of the hierarchical formation of the Milky Way.
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| 8. |
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| 9. |
- Marklund, Birgitta, et al.
(författare)
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Adolescents´experiences of living with food hypersensitivity : A qualitative study
- 2007
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Ingår i: BMC Nursing. - : BioMed Central (BMC). - 1472-6955. ; :6
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Tidskriftsartikel (refereegranskat)abstract
- Experiencing or being at risk of adverse reactions to certain food items is a common health issue, especially among children and adolescents. Research has shown that living with the risk of food reactions and always having to take measures to avoid certain food in one's diet has a negative impact on quality of life. The aim of this study was to illuminate adolescents' experiences of being food hypersensitive.Three focus group interviews and six individual interviews were carried out with all together 17 adolescents, 14–18 years of age, who had exclusion diets at school due to food hypersensitivity. The interviews were taped and transcribed verbatim and a qualitative content analysis was carried out. Five categories with subcategories, and one pervading theme, emerged. The categories were: Perceiving oneself as being particular, Feeling constrained, Experiencing others' ignorance, Keeping control, and Feeling it's okay. A pervading theme was conceptualised as Striving to normalise the experience of being food-hypersensitive. The adolescents regarded themselves as competent and courageous, but also described how they avoided the extra attention it implied to ask for special food considerations taken into account. Their self-conceptions were probably essential for their management of and attitude toward the hypersensitivity condition. They felt deprived, and those at risk of severe food reactions experienced insecurity and fear. Feelings of being disregarded were expressed, as well as facing unreliability and a lack of understanding from others. The continual work of constant vigilance and decision-making was described as time-consuming and frustrating. However, the adolescents also experienced considerate and supportive surroundings and were at pains to tone down the negative experiences and consequences of being food-hypersensitive. Food avoidance by itself, and not only the somatic food reactions, brings about consequences with significant impacts on adolescents' lives. The findings from this study have implications for all of those who deal with adolescents who are food-hypersensitive, and not only health professionals. A deeper insight into adolescents' experiences gives an understanding which can improve the care-givers' efforts.
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