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Träfflista för sökning "WFRF:(Nordström Jan) srt2:(2000-2004)"

Sökning: WFRF:(Nordström Jan) > (2000-2004)

  • Resultat 1-10 av 42
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  • Eriksson, Kristina, 1962, et al. (författare)
  • Coupling of antigen to cholera toxin for dendritic cell vaccination promotes the induction of MHC class I-restricted cytotoxic T cells and the rejection of a cognate antigen-expressing model tumor.
  • 2004
  • Ingår i: European journal of immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 34:5, s. 1272-81
  • Tidskriftsartikel (refereegranskat)abstract
    • We previously demonstrated that cholera toxin (CT) is highly efficient as a combined carrier and adjuvant for dendritic cell (DC) vaccination, inducing strong Th1-dominated B cell and CD4(+) T cell responses. In this study we show that vaccination with DC pre-pulsed ex vivo with CT-conjugated OVA (OVA-CT) gives rise to OVA-specific CD8(+) T cells that produce IFN-gamma and are cytotoxic for OVA-expressing E.G7 tumor cells both in vitro and in vivo. The induction of specific CD8(+) CTL by OVA-CT-treated DC was associated with enhanced presentation of OVA peptide (SIINFEKL) on MHC class I in combination with an overall activation of the pulsed DC. Vaccination of mice with OVA-CT-pulsed DC resulted in rejection of already established MHC class I-positive, MHC class II-negative, OVA-expressing E.G7 tumors in an antigen-specific, CD8(+) T cell-dependent fashion and was associated with high numbers of tumor-infiltrating CD8(+) T cells. Conjugation of antigen to CT facilitated DC uptake of the linked antigen through the GM1 receptor-binding B subunit and induced strong activation-maturation signals through the biologically active A subunit. These results have interesting implications for DC vaccination aimed at inducing CTL immune responses.
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  • Gong, Jing, et al. (författare)
  • A Stable Hybrid Method for Hyperbolic Problems
  • 2004
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • A stable hybrid method that combines the unstructured finite volume method with high order finite difference methods have been developed. The coupling procedure is based on energy estimates and stability can be guaranteed. Numerical calculations verify that the hybrid method is efficient and accurate.
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  • Kreiss, Gunilla, et al. (författare)
  • Elimination of first order errors in shock calculations
  • 2001
  • Ingår i: SIAM Journal on Numerical Analysis. - : SIAM PUBLICATIONS. - 0036-1429 .- 1095-7170. ; 38:6, s. 1986-1998
  • Tidskriftsartikel (refereegranskat)abstract
    • First order errors downstream of shocks have been detected in computations with higher order shock capturing schemes in one and two dimensions. Based on a matched asymptotic expansion analysis we show how to modify the artificial viscosity and raise the order of accuracy.
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  • Mattsson, Ken, et al. (författare)
  • Accuracy Requirements for Steady and Transient Aerodynamics
  • 2002
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • A numerical study on the benefit of high order methods is performed. Numerical computations of solutions governed by the Euler equations are performed. The propagation of a vortex convected through an empty domain, computations of steady state solutions around a NACA0012 airfoil and vortex-airfoil interaction are considered. These computations show that high order methods are often required in order to capture the significant flow features, especially for transient problems.
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  • Resultat 1-10 av 42
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