| 1. |
- Gasparini, Alessandro, et al.
(författare)
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Prevalence and recognition of chronic kidney disease in Stockholm healthcare
- 2016
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Ingår i: Nephrology, Dialysis and Transplantation. - : Oxford University Press (OUP). - 0931-0509 .- 1460-2385. ; 31:12, s. 2086-2094
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Tidskriftsartikel (refereegranskat)abstract
- Background. Chronic kidney disease (CKD) is common, but the frequency of albuminuria testing and referral to nephrology care has been difficult to measure. We here characterize CKD prevalence and recognition in a complete healthcare utilization cohort of the Stockholm region, in Sweden. Methods. We included all adult individuals (n = 1 128 058) with at least one outpatient measurement of IDMS-calibrated serum creatinine during 2006-11. Estimated glomerular filtration rate (eGFR) was calculated via the CKD-EPI equation and CKD was solely defined as eGFR <60 mL/min/1.73 m(2). We also assessed the performance of diagnostic testing (albuminuria), nephrology consultations, and utilization of ICD-10 diagnoses. Results. A total of 68 894 individuals had CKD, with a crude CKD prevalence of 6.11% [95% confidence interval (CI): 6.07-6.16%] and a prevalence standardized to the European population of 5.38% (5.33-5.42%). CKD was more prevalent among the elderly (28% prevalence >75 years old), women (6.85 versus 5.24% in men), and individuals with diabetes (17%), hypertension (17%) or cardiovascular disease (31%). The frequency of albuminuria monitoring was low, with 38% of diabetics and 27% of CKD individuals undergoing albuminuria testing over 2 years. Twenty-three per cent of the 16 383 individuals satisfying selected KDIGO criteria for nephrology referral visited a nephrologist. Twelve per cent of CKD patients carried an ICD-10 diagnostic code of CKD. Conclusions. An estimated 6% of the adult Stockholm population accessing healthcare has CKD, but the frequency of albuminuria testing, nephrology consultations and registration of CKD diagnoses was suboptimal despite universal care. Improving provider awareness and treatment of CKD could have a significant public health impact.
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| 2. |
- Gustafsson, Nina M. S., et al.
(författare)
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Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
- 2018
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- The glycolytic PFKFB3 enzyme is widely overexpressed in cancer cells and an emerging anticancer target. Here, we identify PFKFB3 as a critical factor in homologous recombination (HR) repair of DNA double-strand breaks. PFKFB3 rapidly relocates into ionizing radiation (IR)-induced nuclear foci in an MRN-ATM-gamma H2AX-MDC1-dependent manner and co-localizes with DNA damage and HR repair proteins. PFKFB3 relocalization is critical for recruitment of HR proteins, HR activity, and cell survival upon IR. We develop KAN0438757, a small molecule inhibitor that potently targets PFKFB3. Pharmacological PFKFB3 inhibition impairs recruitment of ribonucleotide reductase M2 and deoxynucleotide incorporation upon DNA repair, and reduces dNTP levels. Importantly, KAN0438757 induces radiosensitization in transformed cells while leaving non-transformed cells unaffected. In summary, we identify a key role for PFKFB3 enzymatic activity in HR repair and present KAN0438757, a selective PFKFB3 inhibitor that could potentially be used as a strategy for the treatment of cancer.
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| 3. |
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| 4. |
- Norin, Stefan, et al.
(författare)
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Severe infusion-related reactions are uncommon in rituximab-treated CLL patients in clinical practice: Results from a Swedish national observational study
- 2015
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Ingår i: Leukemia Research. - : Elsevier. - 0145-2126 .- 1873-5835. ; 39:1, s. 33-37
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Tidskriftsartikel (refereegranskat)abstract
- There have been concerns about serious infusion-related adverse drug reactions (ADR) with rituximabin chronic lymphocytic leukemia (CLL). We therefore conducted an observational trial in which CLL patients planned for rituximab-containing therapy were eligible. Ninety-six patients from 19 centers were enrolled. The most common regimen was rituximab, fludarabine and cyclophosphamide. Fifty-six patients experienced ADR during rituximab infusion. Reactions greater than= grade 3 occurred in five patients and no cases of tumor lysis syndrome were recorded. Despite a high number of circulating tumor cells few severe ADR were noted. Thus, rituximab containing regimens can be considered safe for CLL patients in general practice.
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| 5. |
- Ålöw, Tobias, et al.
(författare)
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Recensioner
- 2016
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Ingår i: Svensk Exegetisk Årsbok. - Uppsala : Svenska exegetiska sällskapet. - 1100-2298. ; 81, s. 217-284
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Recension (övrigt vetenskapligt/konstnärligt)abstract
- Book reviews:Herbert W. Basser with Marsha B. CohenThe Gospel of Matthew and Judaic Traditions: A Relevance-based Commentary(Tobias Ålöw)Alicia J. Batten och John S. Kloppenborg (red.)James, 1 & 2 Peter, and Early Jesus Traditions(Leonhard Franke)Bible Works 10 (Bo Krister Ljungberg)Derek R. BrownThe God of This Age: Satan in the Churches and Letters of the Apostle Paul(Torsten Löfstedt)William P. Brown (ed.)The Oxford Handbook of the Psalms (David Willgren)Constantine R. CampbellAdvances in the Study of Greek: New Insights for Reading the New Testament (Jan H. Nylund)Nancy L. deClaissé-Walford (ed.) The Shape and Shaping of the Book of Psalms: The Current State of Scholarship(David Willgren)Nancy L. deClaissé-Walford, Rolf A. Jacobson and Beth Laneel Tanner The Book of Psalms(David Willgren)Thomas B. Dozeman, Konrad Schmid och Baruch J. Schwartz (red.) The Pentateuch: International Perspectives on Current Research(Stig Norin)Ole Jakob FiltvedtThe Identity of God’s People and the Paradox of Hebrews(Mikael Tellbe)David Hellholm, Tor Vegge, Øyvind Norderval and Christer Hellholm (eds.)Ablution, Initiation, and Baptism: Late Antiquity, Early Judaism, and Early Christianity(James A. Kelhoffer)Wesley Hill Paul and the Trinity: Persons, Relations, and the Pauline Letters(Mikael Tellbe)Douglas S. HuffmanVerbal Aspect Theory and the Prohibitions in the Greek New Testament(Jan H. Nylund)Thomas KazenScripture, Interpretation, or Authority? Motives and Arguments in Jesus’ Halakic Conflicts(Cecilia Wassén)Judith M. LieuMarcion and the Making of a Heretic: God and Scripture in the Second Century(James A. Kelhoffer)L. Michael Morales (ed.)Cult and Cosmos: Tilting Toward a Temple-Centered Theology(Stefan Green)Mark D. Nanos och Magnus Zetterholm (red.)Paul within Judaism: Restoring the First-Century Context to the Apostle(Martin Landgren)Carol A. Newsom och Brennan W. BreedDaniel: A Commentary(LarsOlov Eriksson)Maren Niehoff (red.)Homer and the Bible in the Eyes of Ancient Interpreters(Blazenka Scheuer)Kurt L. NollCanaan and Israel in Antiquity: A Textbook on History and Religion(Richard Pleijel)Ken Parry (ed.) The Wiley Blackwell Companion to Patristics(Carl Johan Berglund)Ralf Rothenbusch“... abgesondert zur Tora Gottes hin”: Ethnisch-religiöse Identitäten im Esra/Nehemiabuch(Lena-Sofia Tiemeyer)Michael L. SatlowHow the Bible Became Holy(Martin Wessbrandt)Birke Siggelkow-BernerDie jüdischen Feste im Bellum Judaicum des Flavius Josephus(Birger Olsson)Lena-Sofia Tiemeyer och Hans M. Barstad (red.)Continuity and Discontinuity: Chronological and Thematic Development in Isaiah 40–66(Stefan Green)W. Dennis Tucker Jr.Constructing and Deconstructing Power in Psalms 107–150(David Willgren)Helmut Utzschneider och Wolfgang OswaldExodus 1–15(LarsOlov Eriksson)Urban C. Von WahldeThe Gospel and Letters of John, vol. 1:Introduction, Analysis, and Reference The Gospel and Letters of John, vol. 2: Commentary on the Gospel of JohnThe Gospel and Letters of John, vol. 3: Commentary on the Three Johannine Letters(Birger Olsson)Benjamin L. WhiteRemembering Paul: Ancient and Modern Contests over the Image of the Apostle(Martin Wessbrandt)
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