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- Tryggvason, S. H., et al.
(författare)
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A meta-analysis of expression signatures in glomerular disease
- 2013
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Ingår i: Kidney International. - : Elsevier BV. - 0085-2538 .- 1523-1755. ; 84:3, s. 591-599
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Tidskriftsartikel (refereegranskat)abstract
- Glomerular diseases represent major diagnostic and therapeutic challenges with classification of these diseases largely relying on clinical and histological findings. Elucidation of molecular mechanisms of progressive glomerular disease could facilitate quicker development. High-throughput expression profiling reveals all genes and proteins expressed in tissue and cell samples. These methods are very appropriate for glomerular disease as pure glomeruli can be obtained from kidney biopsies. To date, proteome profiling data are only available for normal glomeruli, but more robust transcriptome methods have been applied to many mouse model and a few human glomerular diseases. Here, we have carried out a meta-analysis of currently available glomerular expression data in normal and diseased glomeruli from mice, rats, and humans using a standardized protocol. The results suggest a potential for glomerular transcriptomics in identifying pathogenic pathways, disease monitoring, and the feasibility to use animal models to study human glomerular disease. We also found that currently there are no specific consensus biomarkers or pathways among different disease data sets, indicating there are likely disease-specific mechanisms and expression profiles. Thus, further transcriptomics and proteomics analysis, especially that of dynamic changes in the diseases, may lead to novel diagnostics tools and specific pharmacologic therapies.
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| 4. |
- Bäckström, E., et al.
(författare)
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The FERRUM project: metastable lifetimes in Cr ii
- 2011
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press. - 0035-8711 .- 1365-2966. ; 420:2, s. 1636-1639
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Tidskriftsartikel (refereegranskat)abstract
- Parity forbidden radiative transitions from metastable levels are observed in spectra of low-density astrophysical plasmas. These lines are used as probes of the physical conditions, made possible due to the long lifetime of their upper level. In a joint effort, the FERRUM project aims to obtain new and accurate atomic data for the iron-group elements, and part of this project concerns forbidden lines. The radiative lifetimes of the metastable energy levels 3 d4(a 3 D)4 s c4 D 5/2 and 3 d4(a 3 D)4 s c4 D 7/2 of singly ionized chromium have been measured. The experiment has been performed at the ion storage ring CRYRING. We employed a laser-probing technique developed for measuring long lifetimes. In this article, we present the lifetimes of these levels to be τ5/2= 1.28(16) s and τ7/2= 1.37(7) s, respectively. A comparison with previous theoretical work shows good agreement and the result is discussed in a theoretical context.
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| 5. |
- Fröjdh, Erik, et al.
(författare)
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Depth of interaction and bias voltage dependence of the spectral response in a pixellated CdTe detector operating in time-over-threshold mode subjected to monochromatic X-rays
- 2012
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 7:3, s. Art. no. C03002-
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Tidskriftsartikel (refereegranskat)abstract
- High stopping power is one of the most important figures of merit for X-ray detectors. CdTe is a promising material but suffers from: material defects, non-ideal charge transport and long range X-ray fluorescence. Those factors reduce the image quality and deteriorate spectral information. In this project we used a monochromatic pencil beam collimated through a 20Όm pinhole to measure the detector spectral response in dependance on the depth of interaction. The sensor was a 1mm thick CdTe detector with a pixel pitch of 110Όm, bump bonded to a Timepix readout chip operating in Time-Over-Threshold mode. The measurements were carried out at the Extreme Conditions beamline I15 of the Diamond Light Source. The beam was entering the sensor at an angle of ∌20 degrees to the surface and then passed through ∌25 pixels before leaving through the bottom of the sensor. The photon energy was tuned to 77keV giving a variation in the beam intensity of about three orders of magnitude along the beam path. Spectra in Time-over-Threshold (ToT) mode were recorded showing each individual interaction. The bias voltage was varied between -30V and -300V to investigate how the electric field affected the spectral information. For this setup it is worth noticing the large impact of fluorescence. At -300V the photo peak and escape peak are of similar height. For high bias voltages the spectra remains clear throughout the whole depth but for lower voltages as -50V, only the bottom part of the sensor carries spectral information. This is an effect of the low hole mobility and the longer range the electrons have to travel in a low field. © 2012 IOP Publishing Ltd and Sissa Medialab srl.
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