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- Adler, Niclas, et al.
(författare)
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Integrationdriven Development
- 1997
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Ingår i: Proceedings : the creation of prosperity, business and work opportunities through technology management. - Stockholm : Swedish Society of Mechanical Engineers, Naval Architects and Aeronautical Engineers. - 9163056119
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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- Norrgren, L, et al.
(författare)
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Effects of potential xenoestrogens (DEHP, nonylphenol and PCB) on sexual differentiation in juvenile Atlantic salmon (Salmo salar)
- 1999
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Ingår i: Aquatic Ecosystem Health & Management. - : Michigan State University Press. - 1463-4988 .- 1539-4077. ; 2:3, s. 311-317
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Tidskriftsartikel (refereegranskat)abstract
- The effects of 17β-estradiol and potential xenoestrogens were investigated on Atlantic salmon (Salmo salar). Juvenile salmon fed diets containing 15 and 30 mg 17β-estradiol kg−1 food for 4 weeks after yolk-sac resorption differentiated into 88 and 100% phenotypic females, respectively. The reference group, fed uncontaminated food, consisted of 49% females. A significant overrepresentation of phenotypic females (64%) was recorded in the group fed 1500 mg di-2-ethylhexyl phthalate kg−1 food. Atlantic salmon fed diets contaminated with nonylphenol showed no differences in sex ratios compared with the control group. A significantly increased liver somatic index was detected for groups exposed to diets contaminated with 15 and 30 mg 17β-estradiol, 300 mg nonylphenol or 1500 mg di-2-ethylhexyl phthalate kg−1 food. Intraperitoneal injections of nonylphenol, di-2-ethylhexyl phthalate, or polychlorinated biphenyls 58, 104, 112 and 188 did not induce synthesis of vitellogenin which is considered to be a hallmark for estrogenic activity in in vivo testing. Therefore, in vivo assays, that is, intraperitoneal injection, can not always predict how endocrine processes in organisms are affected by pollutants.
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