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- Kokko, K., et al.
(författare)
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Atomistic study of surfaces and interfaces of Fe-Cr and Fe-Cr-Al alloys
- 2013
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Ingår i: Physical and numerical simulation of materials processing VII. - : Trans Tech Publications Inc.. - 9783037857281 ; , s. 728-733
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Konferensbidrag (refereegranskat)abstract
- Surface and interface properties of Fe-Cr, Fe-Al, and Fe-Cr-Al are studied using Exact Muffin-Tin Orbitals and Monte Carlo methods and with x-ray photoelectron and Auger electron techniques. Surface composition is investigated as a function of oxidation (heating) time. Hard x ray photoelectron spectroscopy (HAXPES) is used to scan non destructively the compositions below the surface. It is found that Cr boosts the Al segregation to the surface.
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| 4. |
- Peltola, Mari T., et al.
(författare)
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Immunoassay for the discrimination of free prostate-specific antigen (fPSA) forms with internal cleavages at Lys(145) or Lys(146) from fPSA without internal cleavages at Lys(145) or Lys(146)
- 2011
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Ingår i: Journal of Immunological Methods. - : Elsevier BV. - 1872-7905 .- 0022-1759. ; 369:1-2, s. 74-80
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Tidskriftsartikel (refereegranskat)abstract
- Total levels of circulating prostate-specific antigen (tPSA) are strongly associated with prostate cancer (PCa) risk and outcome but benign prostate disease is the most frequent cause of a moderately elevated PSA level. Free PSA (fPSA) forms are independently associated with PCa risk and contribute modest diagnostic enhancements above and beyond tPSA alone. We developed an immunoassay for fPSA subfractions containing internal cleavages at Lys(145) or Lys(146) (fPSA-N). The assay was based on blocking intact single-chain fPSA (fPSA-I) with antibody 4D4 which does not detect PSA containing internal cleavages at Lys(145) or Lys(146). We also measured fPSA-N in blood from healthy volunteers and in anti-coagulated plasma from 76 men with or without evidence of PCa at biopsy. The analytical and functional detection limits of this assay were 0.016 ng/mL and 0.10 ng/mL, respectively. The median recovery of male fPSA-N from female plasma was 95.0%. All 12 female samples (average age 28 years) had fPSA-N concentrations at or below the analytical detection limit. The median fPSA-N concentration (0.050 ng/mL) in 9 healthy male volunteers (age <40 years) was below the functional detection limit, 0.420 ng/mL in 27 patients with benign prostate conditions and 0.239 ng/mL in 49 patients with PCa. Deming regression analysis of the patient samples showed that the measured fPSA-N concentrations were generally 23% lower than the previously calculated (fPSA minus fPSA-I) concentrations, likely due to differences in the antibody combinations used. In conclusion, we have developed a sensitive, specific and direct immunoassay for fPSA-N which can be used to study the clinical relevance of this PSA isoform. (C) 2011 Elsevier B.V. All rights reserved.
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| 6. |
- Tasinato, Gianmassimo, et al.
(författare)
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Loop corrections and a new test of inflation
- 2013
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 87:4, s. 043512-
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Tidskriftsartikel (refereegranskat)abstract
- Inflation is the leading paradigm for explaining the origin of primordial density perturbations. However many open questions remain, in particular whether one or more scalar fields were present during inflation and how they contributed to the primordial density perturbation. We propose a new observational test of whether multiple fields or only one (not necessarily the inflaton) generated the perturbations. We show that our test, relating the bispectrum and trispectrum, is protected against loop corrections at all orders, unlike previous relations. DOI: 10.1103/PhysRevD.87.043512
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| 7. |
- Tirkkonen, J., et al.
(författare)
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Cardiac arrest teams and medical emergency teams in Finland : a nationwide cross- sectional postal survey
- 2014
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Ingår i: Acta Anaesthesiologica Scandinavica. - : Wiley. - 0001-5172 .- 1399-6576. ; 58:4, s. 420-427
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe implementation, characteristics and utilisation of cardiac arrest teams (CATs) and medical emergency teams (METs) in Finland are unknown. We aimed to evaluate how guidelines on advanced in-hospital resuscitation have been translated to practice. MethodsA cross-sectional postal survey including all public hospitals providing anaesthetic services. ResultsOf the 55 hospitals, 51 (93%) participated in the study. All hospitals with intensive care units (university and central hospitals, n=24) took part. In total, 88% of these hospitals (21/24) and 30% (8/27) of the small hospitals had CATs. Most hospitals with CATs (24/29) recorded team activations. A structured debriefing after a resuscitation attempt was organised in only one hospital. The median incidence of in-hospital cardiac arrest in Finland was 1.48 (Q(1)=0.93, Q(3)=1.93) per 1000 hospital admissions. METs had been implemented in 31% (16/51) of the hospitals. A physician participated in MET activation automatically in half (8/16) of the teams. Operating theatres (13/16), emergency departments (10/16) and paediatric wards (7/16) were the most common sites excluded from the METs' operational areas. The activation thresholds for vital signs varied between hospitals. The lower upper activation threshold for respiratory rate was associated with a higher MET activation rate. The national median MET activation rate was 2.3 (1.5, 4.8) per 1000 hospital admissions and 1.5 (0.96, 4.0) per every cardiac arrest. ConclusionsCurrent guidelines emphasise the preventative actions on in-hospital cardiac arrest. Practices are changing accordingly but are still suboptimal especially in central and district hospitals. Unified guidelines on rapid response systems are required.
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