Sökning: WFRF:(Nyandoro Stephen S. 1975)
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Polyoxygenated cycl...
Polyoxygenated cyclohexene derivatives and flavonoids from the leaves of Uvaria pandensis.
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- Maeda, Gasper (författare)
- Uppsala universitet,Organisk kemi,Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box. 35061, Dar es Salaam, Tanzania
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- Gilissen, Pieter J (författare)
- Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
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- Bourgard, Catarina, 1985 (författare)
- Gothenburg University,Göteborgs universitet,CARe - Centrum för antibiotikaresistensforskning,Institutionen för kemi och molekylärbiologi,Centre for antibiotic resistance research, CARe,Department of Chemistry and Molecular Biology,Department of Chemistry and Molecular Biology, Center for Antibiotic Resistance Research (CARe), University of Gothenburg, SE-412 96 Gothenburg, Sweden
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- van der Wal, Jelle (författare)
- Gothenburg University,Göteborgs universitet,CARe - Centrum för antibiotikaresistensforskning,Institutionen för kemi och molekylärbiologi,Centre for antibiotic resistance research, CARe,Department of Chemistry and Molecular Biology,Department of Chemistry and Molecular Biology, Center for Antibiotic Resistance Research (CARe), University of Gothenburg, SE-412 96 Gothenburg, Sweden
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- Munissi, Joan J E (författare)
- Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box. 35061, Dar es Salaam, Tanzania
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- Nyandoro, Stephen S (författare)
- Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box. 35061, Dar es Salaam, Tanzania
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- Erdélyi, Máté, 1975- (författare)
- Uppsala universitet,Organisk kemi
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska.
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Ingår i: Fitoterapia. - : Elsevier BV. - 1873-6971 .- 0367-326X. ; 158
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Three new oxygenated cyclohexene derivatives, pandensenol D - F (1-3), two new flavanoids, pandensone A and B (4-5), and seven known compounds (6-12) were isolated from the methanol extract of the leaves of Uvaria pandensis Verdc. (Annonaceae). The structures were characterized by NMR spectroscopic and mass spectrometric analyses. The isolated metabolites were evaluated for their antibacterial activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus epidermidis and the Gram-negative bacteria Enterococcus raffinosus, Escherichia coli, Paraburkholderia caledonica, Pectobacterium carotovorum and Pseudomonas putida, and for cytotoxicity against the MCF-7 human breast cancer cell line. Out of the tested compounds, pandensenol D (1) and (6',7'-dihydro-8'α,9'β-dihydroxy)-3-farnesylindole (12) showed weak whereas (8'α,9'β-dihydroxy)-3-farnesylindole (11) strong activity against B. subtilis. Four of the isolated compounds (1, 4, 11 and 12) showed moderate cytotoxicity against MCF-7 breast cancer cells (EC50>100μM).
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
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