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- Villa, Luisa L., et al.
(författare)
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Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
- 2007
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 356:19, s. 1915-1927
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the prevention of high-grade cervical lesions associated with HPV-16 and HPV-18. METHODS: In this randomized, double-blind trial, we assigned 12,167 women between the ages of 15 and 26 years to receive three doses of either HPV-6/11/16/18 vaccine or placebo, administered at day 1, month 2, and month 6. The primary analysis was performed for a per-protocol susceptible population that included 5305 women in the vaccine group and 5260 in the placebo group who had no virologic evidence of infection with HPV-16 or HPV-18 through 1 month after the third dose (month 7). The primary composite end point was cervical intraepithelial neoplasia grade 2 or 3, adenocarcinoma in situ, or cervical cancer related to HPV-16 or HPV-18. RESULTS: Subjects were followed for an average of 3 years after receiving the first dose of vaccine or placebo. Vaccine efficacy for the prevention of the primary composite end point was 98% (95.89% confidence interval [CI], 86 to 100) in the per-protocol susceptible population and 44% (95% CI, 26 to 58) in an intention-to-treat population of all women who had undergone randomization (those with or without previous infection). The estimated vaccine efficacy against all high-grade cervical lesions, regardless of causal HPV type, in this intention-to-treat population was 17% (95% CI, 1 to 31). CONCLUSIONS: In young women who had not been previously infected with HPV-16 or HPV-18, those in the vaccine group had a significantly lower occurrence of high-grade cervical intraepithelial neoplasia related to HPV-16 or HPV-18 than did those in the placebo group.
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- Fjellberg, Arne, et al.
(författare)
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2.8. Structural changes in Collembola populations following replanting of birch forest with spruce in North Norway.
- 2007
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Ingår i: Proceedings from the AFFORNORD conference, Reykholt, Iceland June 18-22, 2005.. - 9789289314435 ; , s. 119-125
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The purpose of the present study was to demonstrate possible effects on Collembola populations by changes in tree composition in natural birch forest in coastal North Norway. In the study area (Dønnes, Nordland County) parts of the natural mixed birch forest has been replanted with Norway spruce and Sitka spruce. Soil samples were collected in June and October 2004. A total of 52 species of Collembola were found (36 in birch, 32 Sitka, 34 Norway spruce). Eighteen species were common to all three sites, while birch had 12 unique species. Nine species from the coniferous plantations were not seen in birch, while Norway spruce and Sitka had only minor differences. The most abundant species were Mesaphorura macrochaeta, Isotomiella minor, Parisotoma notabilis and Megalothorax miniumus which made up 55% of all individuals found. Total abundance averaged on 91,000 (Sitka), 53,000 (Norway spruce) and 32,000 (birch) inds./m², with spring densities 40-80% higher than in autumn. The planting of Sitka/Norway spruce changed species composition but gave no significant reduction in species number, while population densities increased considerably.
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- Godoe, H, et al.
(författare)
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System failure, innovation policy and patents: Fuel cells and related hydrogen technology in Norway 1990-2002
- 2006
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Ingår i: Energy Policy. - : Elsevier BV. - 1873-6777 .- 0301-4215. ; 34:13, s. 1697-1708
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Tidskriftsartikel (refereegranskat)abstract
- The empirical focus of this article is technological innovation activities in the emerging field of fuel cells and related hydrogen technology in Norway from 1990 to 2002. In this period, four comparatively large-scale research and development projects and a number of smaller projects aimed at development of fuel cells technology were undertaken, resulting in many inventions that were subsequently patented. Although this creativity may be considered an indication of success, only one of the projects became successful in an innovation perspective. All the large projects were initiated and funded for divergent political and economic reasons. An important reason in the late 1980s was the prospect of using Norway's abundant supply of natural gas in fuel cells for electric power generation. The large R&D projects that attempted to develop fuel cells based on natural gas as energy source failed. In contrast, the successful project was undertaken by military R&D, i.e. in a different system of innovation than the projects that failed. Analysis of these cases points to the importance of a systemic approach to innovations-and to policy making. One challenge for policy makers is to decide how they should promote this development which is crucial for the vision of a future "Hydrogen Economy", i.e. what kind of policy incentives should be introduced to spur efficiency in technological development and diffusion. Theoretically, many options are available; however, understanding the innovation dynamics in this sector is fundamental for making choices. In this article, focus will be set on policy aspects using an innovation systemic approach to analyze development of fuel cells and related hydrogen technology in Norway. (c) 2005 Elsevier Ltd. All rights reserved.
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