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| 2. |
- Abrahamsson, Lena, et al.
(författare)
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Mining and Sustainable Development : Gender, Diversity and Work Conditions in Mining
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Swedish mining companies and surrounding mining communities face many challenges when it comes to social sustainable development. For example, a strong mining workplace culture and community identity can create both strong cohesion but also lead to exclusion of certain groups, rejection of new ideas and reinforce traditional, masculine values. Other challenges include recruitment, as well as health and safety in relation to an increased use of contractors and automation of mining. The social dimension is relatively underdeveloped in studies of sustainable development in general and the mining industry in particular. This report reviews research on social sustainable development and mining with a special focus on (1) diversity of lifestyles, (2) gender, and (3) work conditions. Swedish and international research is reviewed and knowledge gaps are identified. All three areas of research can be regarded as relatively mature and they give important contributions to ourunderstanding of social sustainable development in relation to the mining sector even if they not always explicitly refer to it as such. There is a lack of research that links attitudes, policies and activities within companies to their impact on the wider society, and vice versa. Future research should also include the development of methods and indicators for social sustainability relevant for mining.
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| 3. |
- Eggers, Kai M., et al.
(författare)
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High-sensitive troponin T and I are related to invasive hemodynamic data and mortality in patients with left-ventricular dysfunction and precapillary pulmonary hypertension
- 2011
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Ingår i: Clinica Chimica Acta. - : Elsevier BV. - 0009-8981 .- 1873-3492. ; 412:17-18, s. 1582-1588
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Tidskriftsartikel (refereegranskat)abstract
- Background: High-sensitive (hs) cardiac troponin assays are clinically useful in various cardiac conditions. We aimed to extend current evidence by assessing the relations of hs-cardiac troponin T (hs-cTnT) and I (hs-cTnI) to invasive hemodynamic data and outcome in stable patients with left-ventricular (LV) dysfunction or precapillary pulmonary hypertension (PAH). Methods: Hs-cTnT (Roche Diagnostics) and hs-cTnI (Beckman-Coulter) were measured in 103 stable patients with LV-dysfunction and 56 patients with precapillary PAH referred for right-heart catheterization. Results: Up to 47.6% of patients with LV-dysfunction, and up to 37.5% of patients with precapillary PAH had hs-troponin levels above the respective 99th percentiles. In patients with LV-dysfunction, both hs-troponins exhibited significant associations to hemodynamics, NT-proBNP and mortality (hs-cTnT: age/sex-adjusted HR 2.0 [95% CI 1.3-3.1]: hs-cTnI: age/sex-adjusted HR 1.9 [1.2-2.8]). Both hs-troponins demonstrated weaker associations to hemodynamics in patients with precapillary PAH but correlated significantly to NT-proBNP. Mortality was only predicted by hs-cTnI (age/sex-adjusted HR 3.0 [1.5-6.1]). Conclusions: Hs-troponins are related to indices of impaired myocardial performance in patients with LV-dysfunction and precapillary PAH. Both hs-troponins were also predictive for mortality in patients with LV-dysfunction. In precapillary PAH, only hs-cTnI was independently prognostic which might depend on the superior analytical performance of this assay.
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| 5. |
- Giritli Nygren, Katarina, et al.
(författare)
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Gamla mönster och nya utmaningar : Kartläggning av kvinnors och mäns livs- och arbetsvillkor i Jämtlands och Västernorrlands Län
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport visar att såväl Jämtland som Västernorrland har en könssegregeradarbetsmarknad. Detta gäller både den vertikala könssegregeringen, d.v.s. att män istörre utsträckning innehar chefsposter, och den horisontella könssegregeringen, d.v.s.att större delen av arbetsmarknaderna i Västernorrland och Jämtland utgörs av yrkensom i huvudsak innehas av antingen män eller kvinnor. Även i sociala sfären återfinns ettojämlikt förhållande mellan män och kvinnor. Kvinnor tar ut en mycket större del avföräldraförsäkringen och är sjukskrivna i en större utsträckning än män. Kvinnor är ocksåi regel mer utbildade än män men har trots detta genomgående en lägre lön.Rapporten visar också att det finns tydliga regionala skillnader. Dels så skiljer sig de bådalänen åt i flertalet hänseenden, dels så skiljer de sig från genomsnittet i Sverige. Ettexempel på detta är att Jämtland har en större andel kvinnliga chefer än såväl rikssnittetsom Västernorrland. Ett annat exempel är att skillnaden mellan löneinkomster mellankönen är lägre i Jämtland än i Västernorrland och Sverige som helhet. En generell trendkan skönjas där Jämtland visar upp en något högre jämställdhet än rikssnittet samtidigtsom Västernorrland visar upp en lägre grad av jämställdhet som i de flesta fall ligger iparitet med eller något under rikssnittet. Följaktligen kan två slutsatser dras. (1)Jämställdarbetet måste fortsatt vara en prioritet för att vidare stärka de bägge länensattraktionskraft och utvecklingspotential. (2) De insatser som görs måste vara regionaltkänsliga, d.v.s. beakta länets specifika karaktär och historia, för att få en stark ochlångvarig effekt på jämställdheten.
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| 7. |
- Hultman, Bo, 1964-, et al.
(författare)
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Benchmarking of gastric cancer sensitivity to anti-cancer drugs ex vivo as a basis for drug selection in systemic and intraperitoneal therapy
- 2014
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Ingår i: Journal of Experimental & Clinical Cancer Research. - : Springer Science and Business Media LLC. - 1756-9966. ; 33
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Tidskriftsartikel (refereegranskat)abstract
- Background The choice of drugs for treatment of advanced gastric cancer (GC) is empirical. The purpose of the current study was to benchmark ex vivo the sensitivity of GC tumor cells from patients to standard cytotoxic and some newly introduced targeted drugs (TDs), as a basis for drug selection in the treatment of GC.Methods Tumor cell samples from patients with GC were analyzed for sensitivity to 5-fluorouracil, cisplatin, oxaliplatin, irinotecan, mitomycin C, doxorubicin and docetaxel as well as for the targeted drugs bortezomib, sorafenib, sunitinib and rapamycin using a short-term in vitro assay based on retention of viable tumor cells of fluorescent fluorescein. Samples of normal mononuclear cells, chronic lymphocytic leukemia, ovarian cancer and colorectal cancer were included for comparison.Results The GC samples were essentially as sensitive to the standard drugs and the TDs as those from colorectal cancer whereas the ovarian cancer samples were more sensitive. The individual GC samples varied considerably in sensitivity to increasing concentrations of the clinically used standard drugs. In GC, cisplatin was cross-resistant to oxaliplatin and 5-fluorouracil which, on the other hand, was not cross-resistant to the other cytotoxic drugs. The activity of sunitinib did not obviously correlate to that of the standard drugs.Conclusion Ex vivo assessment of drug sensitivity of tumor cells from patients with GC is feasible and may provide information that could be useful for selection of drugs for treatment. Drug sensitivity varies considerably between and within individual samples arguing for individualized selection of drugs for chemotherapy.
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| 8. |
- Hultman, Bo, et al.
(författare)
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Phase II study of patients with peritoneal carcinomatosis from gastric cancer treated with preoperative systemic chemotherapy followed by peritonectomy and intraperitoneal chemotherapy
- 2013
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Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 52:4, s. 824-830
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe aim was to evaluate the feasibility and the effectiveness of neoadjuvant systemic chemotherapy followed by cytoreductive surgery (CRS), hyperthermic intraperitoneal chemotherapy (HIPEC) and early postoperative intraperitoneal chemotherapy (EPIC) in patients with peritoneal carcinomatosis (PC) from gastric cancer.Material and methodsEighteen patients (median age 57 years, range 38-74) were scheduled for three months' neoadjuvant systemic chemotherapy followed by CRS + HIPEC + EPIC.ResultsAt the time of surgery, the peritoneal tumor burden was extensive with tumor growth on the entire peritoneal cavity. Only eight patients received the entire treatment and OS was 14.3 months (range 6.1-34.3, 95% CI 6.6-20.3). Six patients had macroscopically radical (CC0) surgery and for this subgroup OS was 19.1 months (range 6.1-34.3, 95% CI 6.9-27.1). Postoperative 90-day mortality was 10% (one patient) and the perioperative grades II-IV adverse events (AE) rate was 62.5%.DiscussionNeoadjuvant chemotherapy followed by CRS + HIPEC + EPIC does not seem to be associated with prolonged OS in patients with extensive PC growth from gastric cancer unless macroscopically radical surgery is achieved. However, morbidity from this treatment is considerable and it cannot be recommended for routine care until a prospective randomized trial has been performed.
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| 9. |
- Kashif, Muhammad, et al.
(författare)
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A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses
- 2014
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Ingår i: Molecular Cancer Therapeutics. - 1535-7163 .- 1538-8514. ; 13:7, s. 1964-1976
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Tidskriftsartikel (refereegranskat)abstract
- For decades, the standard procedure when screening for candidate anticancer drug combinations has been to search for synergy, defined as any positive deviation from trivial cases like when the drugs are regarded as diluted versions of each other (Loewe additivity), independent actions (Bliss independence), or no interaction terms in a response surface model (no interaction). Here, we show that this kind of conventional synergy analysis may be completely misleading when the goal is to detect if there is a promising in vitro therapeutic window. Motivated by this result, and the fact that a drug combination offering a promising therapeutic window seldom is interesting if one of its constituent drugs can provide the same window alone, the largely overlooked concept of therapeutic synergy (TS) is reintroduced. In vitro TS is said to occur when the largest therapeutic window obtained by the best drug combination cannot be achieved by any single drug within the concentration range studied. Using this definition of TS, we introduce a procedure that enables its use in modern massively parallel experiments supported by a statistical omnibus test for TS designed to avoid the multiple testing problem. Finally, we suggest how one may perform TS analysis, via computational predictions of the reference cell responses, when only the target cell responses are available. In conclusion, the conventional error-prone search for promising drug combinations may be improved by replacing conventional (toxicology-rooted) synergy analysis with an analysis focused on (clinically motivated) TS.
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| 10. |
- Månsson, Christopher, et al.
(författare)
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Safety and Preliminary Efficacy of Ultrasound-guided Percutaneous Irreversible Electroporation for Treatment of Localized Pancreatic Cancer
- 2014
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 34:1A, s. 289-293
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Tidskriftsartikel (refereegranskat)abstract
- Background:Irreversible electroporation (IRE) is a local tumor treatment. Thin needles are placed percutaneously around the tumor under ultrasound guidance. Short pulses of direct current sent through the tissue irreversibly increase cell membrane permeability leading to cell death. We report a phase I study assessing the safety of ultrasound guided percutaneous IRE in patients with localized pancreatic cancer (LPC).Patients and Methods:Five patients (three males) with LPC, judged unsuitable for surgery, chemotherapy, or non-resectable after standard oncological treatment, were treated with IRE. The treatment was given under general anesthesia with muscle relaxation.Results:No serious treatment-related adverse events were observed. There was no 30-day mortality. One patient went on to laparotomy and had a R0 pancreaticoduodenectomy with portal vein resection. Six months after the treatment, two patients had no signs of recurrence on computed tomography or contrast-enhanced ultrasound.Conclusion: IRE for LPC can be safely performed percutaneously under ultrasound guidance, with promising initial results regarding efficacy.
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