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Träfflista för sökning "WFRF:(Nyström Kristina) srt2:(1997-1999)"

Sökning: WFRF:(Nyström Kristina) > (1997-1999)

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1.
  • Hjelm, Eva, et al. (författare)
  • Assay of antibiotic susceptibility of Chlamydia pneumoniae
  • 1997
  • Ingår i: Scandinavian Journal of Infectious Diseases. Supplementum. - 0300-8878 .- 1651-2502. ; 104, s. 13-14
  • Tidskriftsartikel (refereegranskat)abstract
    • It is well known that treatment of Chlamydia pneumoniae infections is difficult. High doses and prolonged treatment is often needed to achieve clinical cure despite good in vitro effect of the drugs used. We here discuss different methodological problems in the determination of MIC and MBC values of C. pneumoniae. The length of the preincubation time and the lack of fluctuation of the antibiotic concentrations may affect the outcome of the currently used assay.
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2.
  • Nyström-Rosander, Christina, et al. (författare)
  • Susceptibility of Chlamydia pneumoniae to azithromycin and doxycycline : methodological aspects on thedetermination of minimal inhibitory andminimal bactericidal concentrations
  • 1997
  • Ingår i: Scandinavian Journal of Infectious Diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 29:5, s. 513-516
  • Tidskriftsartikel (refereegranskat)abstract
    • An in vitro assay for measuring and comparing the efficacy of different antimicrobial agents against Chlamydia pneumoniae was developed. Azithromycin, a representative of the new azalide group of antibiotics, and doxycycline were evaluated with respect to their antibacterial effect and capacity for intracellular killing under different experimental conditions. For both study drugs, the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values increased significantly with longer bacterial preincubation time. The effect of different exposure times of antibiotics on the bacteria was also studied.
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