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- Newton-Cheh, Christopher, et al.
(författare)
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Genome-wide association study identifies eight loci associated with blood pressure
- 2009
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:6, s. 666-676
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Tidskriftsartikel (refereegranskat)abstract
- Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N <= 71,225 European ancestry, N <= 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10(-24)), CYP1A2 (P = 1 x 10(-23)), FGF5 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF652 (P = 5 x 10(-9)) and PLCD3 (P = 1 x 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.
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- Pereira, M A, et al.
(författare)
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Dietary fiber, folate, and vitamin E with coronary risk : A pooled analysis of cohort studies
- 2006
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Ingår i: Circulation. - Univ Minnesota, Minneapolis, MN USA. Harvard Univ, Boston, MA 02115 USA. Karolinska Inst, Stockholm, Sweden. Loma Linda Univ, Loma Linda, CA 92350 USA. Neufeld Cardiac Res Inst, Tel Hashomer, Israel. Copenhagen Univ Hosp, Copenhagen, Denmark. Umea Univ, Umea, Sweden. Natl Publ Hlth Inst, Helsinki, Finland. Inst Publ Hlth, Helsinki, Finland. Inst Publ Hlth, Helsinki, Finland. Univ N Carolina, Chapel Hill, NC USA. : LIPPINCOTT WILLIAMS & WILKINS. - 0009-7322 .- 1524-4539. ; 113:8, s. E374-E375
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Gustavsson, Johan, 1974, et al.
(författare)
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Optimized active region design for high speed 850 nm VCSELs
- 2009
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Ingår i: CLEO/Europe - EQEC 2009 - European Conference on Lasers and Electro-Optics and the European Quantum Electronics Conference; Munich; Germany; 14 June 2009 through 19 June 2009. - 9781424440801 ; , s. Art. no. 5192928-
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Konferensbidrag (refereegranskat)abstract
- Short wavelength (850 nm) VCSELs operating at speeds of 25 Gb/s and above are needed for future highcapacity, short reach data communication links. The modulation bandwidth is intrinsically limited by thedifferential gain of the QWs used in the active region of the VCSEL. In this work we explore the use of strainedInGaAs/AlGaAs QWs and benchmark the performance against conventional GaAs/AlGaAs QWs.An 8-band k⋅p model [1] was used to calculate the energy band dispersions, using band offsets from modelsolid theory [2]. In all cases, the QW and barrier compositions and QW thickness were chosen for a gain peak at845 nm, enabling emission at 850 nm with a small detuning between the gain peak and the cavity resonance.With increasing In-concentration the QW thickness is reduced and the Al-concentration in the barrier isincreased to maintain the gain peak at 845 nm and the number of QWs is increased to maintain opticalconfinement and enable operation at a low carrier density for high differential gain. It was found that theincorporation of up to 10% In leads to a significant reduction in threshold carrier density and increase indifferential gain. This is due to an increased separation and reduced mixing between the highest heavy-hole andlight-hole valence bands (Fig.1). A further increase of In concentration leads to a less marked improvement.With an optimum active region design (5 x 4 nm In0.10Ga0.90As/Al0.37Ga0.63As QWs) a differential gain twice ashigh as that of a conventional design with 3 x 8 nm GaAs/Al0.30Ga0.70As QWs was predicted (Table 1).The improvement of differential gain was experimentally confirmed by extracting the resonance frequencyand its dependence on current from the modulation response of VCSELs with optimized InGaAs/AlGaAs QWand conventional GaAs/AlGaAs QW active regions. The differential gain was calculated from the correspondingD-factors (Fig.2) [3]. Excellent agreement was obtained between theory and experiments (Table 1).VCSELs with an optimized InGaAs/AlGaAs QW active region have a modulation bandwidth of 20 GHz at25° and 15 GHz at 85°C [4] and have enabled error-free transmission over 50 (100) m multimode fiber up to 32(25) Gb/s at a bias current density as low as 11 kA/cm2 under direct current modulation.
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- Jakobsen, Marianne U, et al.
(författare)
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Major types of dietary fat and risk of coronary heart disease : a pooled analysis of 11 cohort studies.
- 2009
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Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 89:5, s. 1425-1432
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Saturated fatty acid (SFA) intake increases plasma LDL-cholesterol concentrations; therefore, intake should be reduced to prevent coronary heart disease (CHD). Lower habitual intakes of SFAs, however, require substitution of other macronutrients to maintain energy balance. OBJECTIVE: We investigated associations between energy intake from monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), and carbohydrates and risk of CHD while assessing the potential effect-modifying role of sex and age. Using substitution models, our aim was to clarify whether energy from unsaturated fatty acids or carbohydrates should replace energy from SFAs to prevent CHD. DESIGN: This was a follow-up study in which data from 11 American and European cohort studies were pooled. The outcome measure was incident CHD. RESULTS: During 4-10 y of follow-up, 5249 coronary events and 2155 coronary deaths occurred among 344,696 persons. For a 5% lower energy intake from SFAs and a concomitant higher energy intake from PUFAs, there was a significant inverse association between PUFAs and risk of coronary events (hazard ratio: 0.87; 95% CI: 0.77, 0.97); the hazard ratio for coronary deaths was 0.74 (95% CI: 0.61, 0.89). For a 5% lower energy intake from SFAs and a concomitant higher energy intake from carbohydrates, there was a modest significant direct association between carbohydrates and coronary events (hazard ratio: 1.07; 95% CI: 1.01, 1.14); the hazard ratio for coronary deaths was 0.96 (95% CI: 0.82, 1.13). MUFA intake was not associated with CHD. No effect modification by sex or age was found. CONCLUSION: The associations suggest that replacing SFAs with PUFAs rather than MUFAs or carbohydrates prevents CHD over a wide range of intakes.
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