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A hypersensitive es...
A hypersensitive estrogen receptor-alpha mutation in premalignant breast lesions
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- Fuqua, S A (författare)
- Baylor College of Medicine
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- Wiltschke, C (författare)
- Vienna General Hospital / University Hospital Vienna
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- Zhang, Q X (författare)
- University of Alberta
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- Borg, A (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups
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- Castles, C G (författare)
- Montana State University
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- Friedrichs, W E (författare)
- University of Texas Health Science Centre
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- Hopp, T (författare)
- Baylor College of Medicine
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- Hilsenbeck, S (författare)
- Baylor College of Medicine
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- Mohsin, S (författare)
- Baylor College of Medicine
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- O'Connell, P (författare)
- Baylor College of Medicine
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- Allred, D C (författare)
- Baylor College of Medicine
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(creator_code:org_t)
- 2000
- 2000
- Engelska.
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Ingår i: Cancer Research. - 0008-5472. ; 60:15, s. 4026-4029
- Relaterad länk:
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https://cancerres.aa...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- The best current model of breast cancer evolution suggests that most cancers arise from certain premalignant lesions. We have identified a common (34%) somatic mutation in the estrogen receptor (ER)-alpha gene in a series of 59 typical hyperplasias, a type of early premalignant breast lesion. The mutation, which affects the border of the hinge and hormone binding domains of ER-alpha, showed increased sensitivity to estrogen as compared with wild-type ER-alpha in stably transfected breast cancer cells, including markedly increased proliferation at subphysiological levels of estrogen. The mutated ER-alpha exhibits enhanced binding to the TIF-2 coactivator at low levels of hormone, which may partially explain its increased estrogen responsiveness. These data suggest that this mutation may promote or accelerate the development of cancer from premalignant breast lesions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Breast/pathology
- Breast Neoplasms/genetics
- Cell Division/drug effects
- DNA/analysis
- DNA, Neoplasm/analysis
- Dose-Response Relationship, Drug
- Estradiol/pharmacology
- Estrogen Receptor alpha
- Humans
- Hyperplasia/genetics
- Mutation
- Precancerous Conditions/genetics
- Receptors, Estrogen/drug effects
- Reverse Transcriptase Polymerase Chain Reaction
- Transfection
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Fuqua, S A
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Wiltschke, C
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Zhang, Q X
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Borg, A
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Castles, C G
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Friedrichs, W E
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visa fler...
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Hopp, T
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Hilsenbeck, S
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Mohsin, S
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O'Connell, P
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Allred, D C
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Cancer Research
- Av lärosätet
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Lunds universitet