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Search: WFRF:(OGREN J. A.) > (1995-1999)

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  • Ilver, D, et al. (author)
  • Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging
  • 1998
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 279:5349, s. 373-377
  • Journal article (peer-reviewed)abstract
    • The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity-directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori.
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