Sökning: WFRF:(Oemrawsingh Rohit M)
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IgM anti-malondiald...
IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)
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- van den Berg, Victor J (författare)
- Erasmus University Medical Center
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- Haskard, Dorian O (författare)
- Imperial College London
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- Fedorowski, Artur (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Hartley, Adam (författare)
- Imperial College London
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- Kardys, Isabella (författare)
- Erasmus University Medical Center
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Caga-Anan, Mikhail (författare)
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Akkerhuis, K Martijn (författare)
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Oemrawsingh, Rohit M (författare)
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van Geuns, Robert Jan (författare)
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de Jaegere, Peter (författare)
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van Mieghem, Nicolas (författare)
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Regar, Evelyn (författare)
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Ligthart, Jurgen M R (författare)
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- Umans, Victor A W M (författare)
- Northwest Hospital Group, Alkmaar
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Serruys, Patrick W (författare)
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cardiovascular Research - Hypertension,Lund University Research Groups
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Boersma, Eric (författare)
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- Khamis, Ramzi Y (författare)
- Imperial College London
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: EBioMedicine. - : Elsevier BV. - 2352-3964. ; 36, s. 63-72
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://www.thelancet...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Certain immunoglobulins (Ig) are proposed to have protective functions in atherosclerosis.Objectives: We tested whether serum levels of IgG and IgM autoantibodies against malondialdehyde low density lipoprotein (MDA-LDL) are associated with clinical coronary heart disease (CHD) and unfavorable plaque characteristics.Methods: NORDIL was a prospective study investigating adverse cardiovascular outcomes in hypertensive patients. IBIS-3 analyzed lesions in a non-culprit coronary artery with <50% stenosis using radiofrequency intravascular ultrasound (RF-IVUS) and near-infrared spectroscopy (NIRS). Imaging was repeated after a median of 386?days on rosuvastatin. Associations of antibodies with incident CHD and imaging parameters were assessed in the two sub-studies respectively.Findings: From 10,881 NORDIL patients, 87 had serum sampled at baseline and developed CHD over 4.5 years, matched to 227 controls. Higher titers of IgM anti-MDA-LDL had a protective effect on adverse outcomes, with odds ratio 0.29 (0.11, 0.76; p=0.012; p=0.016 for trend). Therefore, the effect was explored at the lesional level in IBIS-3. 143 patients had blood samples and RF-IVUS measurements available, and NIRS was performed in 90 of these. At baseline, IgM anti-MDA-LDL levels had a strong independent inverse relationship with lesional necrotic core volume (p=0.027) and percentage of plaque occupied by necrotic core (p=0.011), as well as lipid core burden index (p=0.024) in the worst 4 mm segment.Interpretation: Our study supports the hypothesis that lower circulating levels of IgM anti-MDA-LDL are associated with clinical CHD development, and for the first time relates these findings to atherosclerotic plaque characteristics that are linked to vulnerability.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Aged
- Atherosclerosis/blood
- Biomarkers/blood
- Coronary Artery Disease/blood
- Female
- Humans
- Immunoglobulin M/blood
- Lipoproteins, LDL/immunology
- Male
- Malondialdehyde/analogs & derivatives
- Middle Aged
- Necrosis/blood
- Prospective Studies
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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van den Berg, Vi ...
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Haskard, Dorian ...
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Fedorowski, Artu ...
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Hartley, Adam
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Kardys, Isabella
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Caga-Anan, Mikha ...
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Akkerhuis, K Mar ...
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Oemrawsingh, Roh ...
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van Geuns, Rober ...
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de Jaegere, Pete ...
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van Mieghem, Nic ...
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Regar, Evelyn
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Ligthart, Jurgen ...
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Umans, Victor A ...
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Serruys, Patrick ...
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Melander, Olle
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Boersma, Eric
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Khamis, Ramzi Y
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