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Pharmacological mod...
Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis
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- Huang, Yi Shu (författare)
- Kennedy Institute of Rheumatology,Chang Gung Memorial Hospital
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- Tseng, Wen Yi (författare)
- Kennedy Institute of Rheumatology,Chang Gung University,Chang Gung Memorial Hospital
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- Clanchy, Felix I.L. (författare)
- University of Oxford,Kennedy Institute of Rheumatology
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- Topping, Louise M. (författare)
- Kennedy Institute of Rheumatology
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- Ogbechi, Joy (författare)
- Kennedy Institute of Rheumatology
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- McNamee, Kay (författare)
- Kennedy Institute of Rheumatology
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- Perocheau, Dany (författare)
- Kennedy Institute of Rheumatology
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- Chiang, Nien Yi (författare)
- Kennedy Institute of Rheumatology
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- Ericsson, Peter (författare)
- Lund University,Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Rausing laboratory of Lund - Tumor section,Lund University Research Groups
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- Sundstedt, Anette (författare)
- Lund University,Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Rausing laboratory of Lund - Tumor section,Lund University Research Groups
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- Xue, Zhong Tian (författare)
- Skåne University Hospital
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- Salford, Leif G. (författare)
- Lund University,Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Rausing laboratory of Lund - Tumor section,Lund University Research Groups
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- Sjögren, Hans Olov (författare)
- Lund University,Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Rausing laboratory of Lund - Tumor section,Lund University Research Groups
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- Stone, Trevor W. (författare)
- Kennedy Institute of Rheumatology
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- Lin, Hsi Hsien (författare)
- Chang Gung Memorial Hospital,Chang Gung University
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- Luo, Shue Fen (författare)
- Chang Gung Memorial Hospital
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- Williams, Richard O. (författare)
- Kennedy Institute of Rheumatology
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(creator_code:org_t)
- 2021-05-03
- 2021
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 118:19
- Relaterad länk:
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http://dx.doi.org/10...
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https://www.pnas.org...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Chronic inflammatory diseases like rheumatoid arthritis are characterized by a deficit in fully functional regulatory T cells. DNA-methylation inhibitors have previously been shown to promote regulatory T cell responses and, in the present study, we evaluated their potential to ameliorate chronic and acute animal models of rheumatoid arthritis. Of the drugs tested, decitabine was the most effective, producing a sustained therapeutic effect that was dependent on indoleamine 2,3-dioxygenase (IDO) and was associated with expansion of induced regulatory T cells, particularly at the site of disease activity. Treatment with decitabine also caused apoptosis of Th1 and Th17 cells in active arthritis in a highly selective manner. The molecular basis for this selectivity was shown to be ENT1, a nucleoside transporter, which facilitates intracellular entry of the drug and is up-regulated on effector T cells during active arthritis. It was further shown that short-term treatment with decitabine resulted in the generation of a population of regulatory T cells that were able to suppress arthritis upon adoptive transfer. In summary, a therapeutic approach using an approved drug is described that treats active inflammatory disease effectively and generates robust regulatory T cells with the IDO-dependent capacity to maintain remission.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- autoimmunity
- DNA-methylation inhibitor
- indoleamine 2,3-dioxygenase
- rheumatoid arthritis
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Huang, Yi Shu
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Tseng, Wen Yi
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Clanchy, Felix I ...
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Topping, Louise ...
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Ogbechi, Joy
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McNamee, Kay
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visa fler...
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Perocheau, Dany
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Chiang, Nien Yi
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Ericsson, Peter
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Sundstedt, Anett ...
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Xue, Zhong Tian
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Salford, Leif G.
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Sjögren, Hans Ol ...
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Stone, Trevor W.
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Lin, Hsi Hsien
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Luo, Shue Fen
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Williams, Richar ...
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visa färre...
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Lunds universitet