WFRF:(Ojeda Francisco M.)
Sökning: WFRF:(Ojeda Francisco M.) > (2015) > Assessment of PaO2/...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Assessment of PaO2/FiO(2) for stratification of patients with moderate and severe acute respiratory distress syndrome
-
- Villar, Jesus (författare)
- Inst Salud Carlos III, CIBER Enfermedades Resp, Madrid, Spain.;Hosp Univ Dr Negrin, Res Unit, Multidisciplinary Organ Dysfunct Evaluat Res Netw, Las Palmas Gran Canaria, Spain.
-
- Blanco, Jesus (författare)
- Inst Salud Carlos III, CIBER Enfermedades Resp, Madrid, Spain.;Hosp Univ Rio Hortega, Intens Care Unit, Valladolid, Spain.
-
- del Campo, Rafael (författare)
- Hosp Gen Ciudad Real, Intens Care Unit, Ciudad Real, Spain.
- visa fler...
- visa färre...
- Inst Salud Carlos III, CIBER Enfermedades Resp, Madrid, Spain;Hosp Univ Dr Negrin, Res Unit, Multidisciplinary Organ Dysfunct Evaluat Res Netw, Las Palmas Gran Canaria, Spain. Inst Salud Carlos III, CIBER Enfermedades Resp, Madrid, Spain.;Hosp Univ Rio Hortega, Intens Care Unit, Valladolid, Spain. (creator_code:org_t)
- 2015-03-27
- 2015
- Engelska.
- Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 5:3
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Objectives: A recent update of the definition of acute respiratory distress syndrome (ARDS) proposed an empirical classification based on ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO(2)) at ARDS onset. Since the proposal did not mandate PaO2/FiO(2) calculation under standardised ventilator settings (SVS), we hypothesised that a stratification based on baseline PaO2/FiO(2) would not provide accurate assessment of lung injury severity. Design: A prospective, multicentre, observational study. Setting: A network of teaching hospitals. Participants: 478 patients with eligible criteria for moderate (100300). Primary and secondary outcomes: Group severity and hospital mortality. Results: At ARDS onset, 173 patients had a PaO2/FiO(2)<= 100 but only 38.7% met criteria for severe ARDS at 24 h under SVS. When assessed under SVS, 61.3% of patients with severe ARDS were reclassified as moderate, mild and non-ARDS, while lung severity and hospital mortality changed markedly with every PaO2/FiO(2) category (p<0.000001). Our model of risk stratification outperformed the stratification using baseline PaO2/FiO(2) and non-standardised PaO2/FiO(2) at 24 h, when analysed by the predictive receiver operating characteristic (ROC) curve: area under the ROC curve for stratification at baseline was 0.583 (95% CI 0.525 to 0.636), 0.605 (95% CI 0.552 to 0.658) at 24 h without SVS and 0.693 (95% CI 0.645 to 0.742) at 24 h under SVS (p<0.000001). Conclusions: Our findings support the need for patient assessment under SVS at 24 h after ARDS onset to assess disease severity, and have implications for the diagnosis and management of ARDS patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Villar, Jesus
- Blanco, Jesus
- del Campo, Rafae ...
- Andaluz-Ojeda, D ...
- Diaz-Dominguez, ...
- Muriel, Arturo
- visa fler...
- Corcoles, Virgil ...
- Suarez-Sipmann, ...
- Tarancon, Concep ...
- Gonzalez-Higuera ...
- Lopez, Julia
- Blanch, Lluis
- Perez-Mendez, Li ...
- Fernandez, Rosa ...
- Kacmarek, Robert ...
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Lungmedicin och ...
- Artiklar i publikationen
- BMJ Open
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
