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Sökning: WFRF:(Oksala M.) > (2020-2022)

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1.
  • Shultz, M. E., et al. (författare)
  • Ultraviolet spectropolarimetry with Polstar : using Polstar to test magnetospheric mass-loss quenching
  • 2022
  • Ingår i: Astrophysics and Space Science. - : Springer Nature. - 0004-640X .- 1572-946X. ; 367:12
  • Tidskriftsartikel (refereegranskat)abstract
    • Polstar is a proposed NASA MIDEX space telescope that will provide high-resolution, simultaneous full-Stokes spectropolarimetry in the far ultraviolet, together with low-resolution linear polarimetry in the near ultraviolet. This observatory offers unprecedented capabilities to obtain unique information on the magnetic and plasma properties of the magnetospheres of hot stars. We describe an observing program making use of the known population of magnetic hot stars to test the fundamental hypothesis that magnetospheres should act to rapidly drain angular momentum, thereby spinning the star down, whilst simultaneously reducing the net mass-loss rate. Both effects are expected to lead to dramatic differences in the evolution of magnetic vs. non-magnetic stars.
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2.
  • Huhtaniemi, R., et al. (författare)
  • High intratumoral dihydrotestosterone is associated with antiandrogen resistance in VCaP prostate cancer xenografts in castrated mice
  • 2022
  • Ingår i: iScience. - : Elsevier BV. - 2589-0042. ; 25:5
  • Tidskriftsartikel (refereegranskat)abstract
    • Antiandrogen treatment resistance is a major clinical concern in castration-resistant prostate cancer (CRPC) treatment. Using xenografts of VCaP cells we showed that growth of antiandrogen resistant CRPC tumors were characterized by a higher intratumor dihydrotestosterone (DHT) concentration than that of treatment responsive tumors. Furthermore, the slow tumor growth after adrenalectomy was associated with a low intratumor DHT concentration. Reactivation of androgen signaling in enzalutamide-resistant tumors was further shown by the expression of several androgen-dependent genes. The data indicate that intratumor DHT concentration and expression of several androgen-dependent genes in CRPC lesions is an indication of enzalutamide treatment resistance and an indication of the need for further androgen blockade. The presence of an androgen synthesis, independent of CYP17A1 activity, has been shown to exist in prostate cancer cells, and thus, novel androgen synthesis inhibitors are needed for the treatment of enzalutamide-resistant CRPC tumors that do not respond to abiraterone.
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