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Type 2 diabetes cla...
Type 2 diabetes classification : a data-driven cluster study of the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort
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- Christensen, Diana Hedevang (författare)
- Aarhus University Hospital
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- Nicolaisen, Sia K. (författare)
- Aarhus University Hospital
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- Ahlqvist, Emma (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Stidsen, Jacob V. (författare)
- Odense University Hospital
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- Nielsen, Jens Steen (författare)
- University of Southern Denmark,Odense University Hospital
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- Hojlund, Kurt (författare)
- Odense University Hospital
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- Olsen, Michael H. (författare)
- University of Southern Denmark,Holbæk Hospital
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- García-Calzón, Sonia (författare)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,University of Navarra,Skåne University Hospital
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- Ling, Charlotte (författare)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Skåne University Hospital
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- Rungby, Jørgen (författare)
- Bispebjerg Hospital
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- Brandslund, Ivan (författare)
- Vejle Hospital
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- Vestergaard, Peter (författare)
- Aalborg University Hospital
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- Jessen, Niels (författare)
- Aarhus University Hospital
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- Hansen, Torben (författare)
- University of Copenhagen
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- Brøns, Charlotte (författare)
- Gentofte Hospital
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- Beck-Nielsen, Henning (författare)
- Odense University Hospital
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- Sørensen, Henrik T. (författare)
- Aarhus University Hospital
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- Thomsen, Reimar W. (författare)
- Aarhus University Hospital
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- Vaag, Allan (författare)
- Gentofte Hospital
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(creator_code:org_t)
- 2022-04-15
- 2022
- Engelska.
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Ingår i: BMJ Open Diabetes Research and Care. - : BMJ. - 2052-4897. ; 10:2
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction A Swedish data-driven cluster study identified four distinct type 2 diabetes (T2D) clusters, based on age at diagnosis, body mass index (BMI), hemoglobin A1c (HbA1c) level, and homeostatic model assessment 2 (HOMA2) estimates of insulin resistance and beta-cell function. A Danish study proposed three T2D phenotypes (insulinopenic, hyperinsulinemic, and classical) based on HOMA2 measures only. We examined these two new T2D classifications using the Danish Centre for Strategic Research in Type 2 Diabetes cohort. Research design and methods In 3529 individuals, we first performed a k-means cluster analysis with a forced k-value of four to replicate the Swedish clusters: severe insulin deficient (SIDD), severe insulin resistant (SIRD), mild age-related (MARD), and mild obesity-related (MOD) diabetes. Next, we did an analysis open to alternative k-values (ie, data determined the optimal number of clusters). Finally, we compared the data-driven clusters with the three Danish phenotypes. Results Compared with the Swedish findings, the replicated Danish SIDD cluster included patients with lower mean HbA1c (86 mmol/mol vs 101 mmol/mol), and the Danish MOD cluster patients were less obese (mean BMI 32 kg/m 2 vs 36 kg/m 2). Our data-driven alternative k-value analysis suggested the optimal number of T2D clusters in our data to be three, rather than four. When comparing the four replicated Swedish clusters with the three proposed Danish phenotypes, 81%, 79%, and 69% of the SIDD, MOD, and MARD patients, respectively, fitted the classical T2D phenotype, whereas 70% of SIRD patients fitted the hyperinsulinemic phenotype. Among the three alternative data-driven clusters, 60% of patients in the most insulin-resistant cluster constituted 76% of patients with a hyperinsulinemic phenotype. Conclusion Different HOMA2-based approaches did not classify patients with T2D in a consistent manner. The T2D classes characterized by high insulin resistance/hyperinsulinemia appeared most distinct.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- classification
- clusters
- cohort
- type 2 diabetes
- ANDIS
- diabetes
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- art (ämneskategori)
- ref (ämneskategori)
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Christensen, Dia ...
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Nicolaisen, Sia ...
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Ahlqvist, Emma
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Stidsen, Jacob V ...
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Nielsen, Jens St ...
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Hojlund, Kurt
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Olsen, Michael H ...
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García-Calzón, S ...
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Ling, Charlotte
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Rungby, Jørgen
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Brandslund, Ivan
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Vestergaard, Pet ...
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Jessen, Niels
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Hansen, Torben
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Brøns, Charlotte
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Beck-Nielsen, He ...
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Sørensen, Henrik ...
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Thomsen, Reimar ...
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Vaag, Allan
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