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Träfflista för sökning "WFRF:(Olsson Anna) srt2:(2000-2004)"

Sökning: WFRF:(Olsson Anna) > (2000-2004)

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  • Bergh, Gösta, et al. (författare)
  • Forced expression of the cyclin-dependent kinase inhibitor p16(INK4A) in leukemic U-937 cells reveals dissociation between cell cycle and differentiation
  • 2001
  • Ingår i: Experimental Hematology. - 1873-2399. ; 29:12, s. 1382-1391
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: The aim of this study was to investigate how the tumor suppressor protein p16(INK4A) interferes with growth and differentiation of leukemic U-937 cells. MATERIALS AND METHODS: U-937 clones constantly overexpressing the cyclin-dependent kinase inhibitor p16(INK4A) were established. Clones transfected with empty vector were used as controls. The effects of high-level expression of p16(INK4A) on proliferation and cell cycle progression were investigated (cell cycle distribution, proliferation rate, analyses of different cell cycle regulatory proteins). The effect of introduction of p16(INK4A) on capacity for induced differentiation, assayed by capacity to reduce nitroblue tetrazolium, was determined. RESULTS: Overexpressed p16(INK4A) protein was active as judged by its ability to bind to CDK-4 in a coimmunoprecipitation assay. Clones overexpressing p16(INK4A) grew slower than controls, without any apparent effects on the phosphorylation status of the retinoblastoma protein (pRb). Instead, p16(INK4A) overexpression affected the phosphorylation status of pRb-related pocket protein p130, which was detected in its growth-restraining hypophosphorylated form. Despite an enhanced tendency to accumulate in G(0)/G(1), p16(INK4A)-overexpressing cells were less sensitive to induction of differentiation with vitamin D(3) or ATRA than control cells. CONCLUSIONS: Constitutive expression of p16(INK4A) in U-937 cells resulted in decreased proliferation as a result of activated p130 rather than pRb. Also, we showed that introduction of p16(INK4A) into U-937 cells impaired their capacity to differentiate. Moreover, the results support the notion that cell differentiation and cell cycle progression are dissociated and independently regulated processes.
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  • Juslin, Peter, et al. (författare)
  • Exemplar effects in categorization and multiple-cue judgment
  • 2003
  • Ingår i: Journal of Experimental Psychology: General. - : AMER PSYCHOLOGICAL ASSOC, WASHINGTON. - 0096-3445. ; 132:1, s. 133-156
  • Tidskriftsartikel (refereegranskat)abstract
    • Categorization and multiple-cue judgment are similar tasks, but the influential models in the two areas are different in terms of the computations, processes, and neural substrates that they imply. In categorization, exemplar memory is often emphasized, w
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  • Olsson, Anna-Carin, et al. (författare)
  • Multiple-cue judgment in individual and dyadic learning
  • 2003
  • Ingår i: Proceedings of the Twenty-Fifth Annual Conference of the Cognitive Science Society. - : Cognitive Science Society, Boston, Massachusetts, USA. ; , s. 880-885
  • Konferensbidrag (refereegranskat)abstract
    • Most studies of multiple-cue judgment focus on learning by individuals. In a multiple-cue judgment task we examined if people acquire rule or exemplar knowledge as a function of learning the task alone or in dyads. The expectation was that learning in dya
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  • Andersson, Per-Ola, 1964, et al. (författare)
  • Reduced transforming growth factor-beta1 production by mononuclear cells from patients with active chronic idiopathic thrombocytopenic purpura.
  • 2002
  • Ingår i: British journal of haematology. - 0007-1048 .- 1365-2141. ; 116:4, s. 862-7
  • Tidskriftsartikel (refereegranskat)abstract
    • Chronic idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder in which activated T-helper (Th) cells and different Th-cell cytokines might play an important role. We have recently reported that chronic ITP patients in remission had elevated plasma levels of the Th3 cytokine transforming growth factor-beta1 (TGF-beta1), possibly as a part of a bystander immune suppression. In the present study we found that, in ITP patients with active disease [platelet count (plc) < 50 x 10(9)/l], mitogen-stimulated peripheral blood mononuclear cells (PBMC) had a significantly reduced production of TGF-beta1 (444 +/- 178 pg/ml; n = 6) compared with patients with plc 50-150 x 10(9)/l (1293 +/- 374 pg/ml; n = 9; P < 0.05), patients with plc >150 x 10(9)/l (1894 +/- 244 pg/ml; n =12; P <0.005) and healthy controls (1698 +/- 241 pg/ml; n = 10; P < 0.01). Nineteen per cent of ITP patients expressed a platelet-induced PBMC proliferation. Surprisingly, 22% of the ITP patients had a PBMC proliferation below the normal range, i.e. a suppressed proliferation in the presence of platelets; five of these six patients had active disease. In summary, this study demonstrated that chronic ITP patients with active disease had reduced PBMC production of the Th3 cytokine TGF-beta1. This result gives further support to the theory that chronic ITP in active phase is associated with a downregulated Th3-response.
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