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- Olsson, Gabriella, et al.
(författare)
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Identifying factors associated with good and ill health. Not just opposite sides of the same coin
- 2009
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Ingår i: International Journal of Behavioral Medicine. - : Springer Science and Business Media LLC. - 1070-5503 .- 1532-7558. ; 16:4, s. 323-330
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Tidskriftsartikel (refereegranskat)abstract
- Background Work-related health research has traditionally focused on identifying risks rather than determinants of good health. Our knowledge of variation in ill health is thus greater than our understanding of such variations in good health. Purpose In this study, the associations between work-environment exposures and good health are examined. We are especially interested in contrasting our indices of ill health with a narrow measure of good health. Moreover, the salutary effect of sense of coherence (SOC) is explored, focusing particularly on its moderating role. Method Data stem from the panel of Swedish level of living surveys for 1991 and 2000. The analysis is based on a sample of 2,334 employed men and women. Logistic regressions are used. Results Assessed work-environment factors are to a large extent related, in a mirrored way, to good health and ill health. The models' fit are, however, generally better for the latter. Our findings also indicate that SOC has a protective role for individuals exposed to work risks such as stress and high physical demands. Conclusion To improve our understanding of what promotes good health, research needs to focus on salutary factors. One such salutary factor explored in this paper is sense of coherence.
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| 2. |
- Varas, Laura, et al.
(författare)
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Alpha10 integrin expression is up-regulated on fibroblast growth factor-2-treated mesenchymal stem cells with improved chondrogenic differentiation potential.
- 2007
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Ingår i: Stem Cells and Development. - : Mary Ann Liebert Inc. - 1557-8534 .- 1547-3287. ; 16:6, s. 965-978
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Tidskriftsartikel (refereegranskat)abstract
- Mesenchymal stem cells (MSCs) are multipotent cells that have the capacity to differentiate into various different cell lineages and can generate bone, cartilage and adipose tissue. MSCs are presently characterized using a broad range of different cell-surface markers that are not exclusive to MSCs and not sensitive to culture conditions or differentiation capacity. We show that the integrin subunits alpha10 and alpha11 of the collagen binding integrins alpha10beta1 and alpha11beta1 are expressed by human MSCs in monolayer cultures. We also demonstrate that the expression of alpha10 increases, while alpha1 and alpha11 decrease, during aggregate culture of MSCs in chondrogenic medium. Alpha10beta1 is expressed by chondrocytes in cartilage, whereas alpha11beta1 integrins are predominantly expressed by subsets of the fibroblastic lineage. In extensive monolayer cultures of MSCs, alpha10 expression is down-regulated. We show that this down-regulation is reversed by fibroblast growth factor-2 (FGF-2) treatment. Addition of FGF-2 to MSCs not only results in increased alpha10 expression, but also in decreased alpha11 expression. FGF-2 treatment of MSCs has been shown to keep the cells more multipotent and also induces cell proliferation and Sox-9 up-regulation. We demonstrate improved chondrogenecity as well as increased collagen-dependant migratory potential of FGF-2-treated MSCs having a high alpha10 expression. We also demonstrate expression of alpha10 and alpha11 integrin subunits in the endosteum and periosteum of mice, but very low or not detectable expression levels in freshly aspired human or mouse BM. We show that MSCs with high chondrogenic differentiation potential are highly alpha10 positive and propose alpha10 as a potential marker to predict the differentiation state of MSCs.
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