| 1. |
- Ambrosi, Aurelie, et al.
(författare)
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Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern
- 2012
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Ingår i: Annals of the Rheumatic Diseases. - London : BMJ Publishing Group. - 0003-4967 .- 1468-2060. ; 71:3, s. 334-340
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Tidskriftsartikel (refereegranskat)abstract
- Objective Congenital heart block may develop in the fetuses of Ro/SSA-positive and La/SSB-positive mothers. Recurrence rates of only 10-20% despite persisting maternal antibodies indicate that additional factors are critical for the establishment of heart block. The authors investigated the influence of other maternal and fetal factors on heart block development in a Swedish population-based cohort. less thanbrgreater than less thanbrgreater thanMethods The influence of fetal gender, maternal age, parity and time of birth on heart block development was analysed in 145 families, including Ro/La-positive (n=190) and Ro/La-negative (n=165) pregnancies. less thanbrgreater than less thanbrgreater thanResults There was a recurrence rate of 12.1% in Ro/La-positive women, and no recurrence in Ro/La-negative women. Fetal gender and parity did not influence the development of heart block in either group. Maternal age in Ro/La-positive pregnancies with a child affected by heart block was, however, significantly higher than in pregnancies resulting in babies without heart block (pandlt;0.05). Seasonal timing of pregnancy influenced the outcome. Gestational susceptibility weeks 18-24 occurring during January-March correlated with a higher proportion of children with heart block and lower vitamin D levels during the same period in a representative sample of Swedish women and a corresponding higher proportion of children with heart block born in the summer (pandlt;0.02). Maternal age or seasonal timing of pregnancy did not affect the outcome in Ro/La-negative pregnancies. less thanbrgreater than less thanbrgreater thanConclusion This study identifies maternal age and seasonal timing of pregnancy as novel risk factors for heart block development in children of Ro/La-positive women. These observations may be useful for counselling when pregnancy is considered.
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| 2. |
- Ben-Menachem, Elinor, 1945, et al.
(författare)
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Epilepsi
- 2011
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Ingår i: Läkemedelsboken 2011-2012. - Uppsala. : Läkemedelsverket. - 9789197960502 ; , s. 965-76
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Bokkapitel (refereegranskat)
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| 3. |
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| 4. |
- Olsson, Ingrid, 1948, et al.
(författare)
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Epilepsy surgery in children with accompanying impairments.
- 2013
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Ingår i: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. - : Elsevier BV. - 1532-2130. ; 17:6, s. 645-650
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to assess seizure outcome 2 years after epilepsy surgery in a consecutive series of paediatric patients, with special focus on children with learning disabilities and other neuroimpairments in addition to the epilepsy. Outcome 2 years after surgery was assessed in 110 of 125 children operated upon for drug resistant epilepsy in Gothenburg 1987-2006. More than half of the children had learning disabilities, 43% motor impairments and 30% a neuropsychiatric diagnosis. Fifty-six per cent of those with an IQ<70 became seizure-free or had a >75% reduction in seizure frequency, and two thirds if the operation was a resection. The corresponding figure in those with more than 100 seizures per month was 15 out of 31, and another seven had a 50-75% reduction in seizure frequency. The message is that learning disability, motor impairment and psychiatric morbidity should not be contraindications for paediatric epilepsy surgery. More than half of the children with learning disabilities had a worthwhile seizure outcome, with even better results after resective surgery. Children with drug resistant epilepsy and additional severe neurological impairments should have the benefit of referral to a tertiary centre for evaluation for epilepsy surgery.
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| 5. |
- Olsson, Ingrid, 1948
(författare)
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Ryggmärgsbråck (myelomenineocele)
- 2012
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Ingår i: Barnmedicin, (red) K.Hanseus, H.Lagercrantz, T. Lindberg.. - Lund : Studentlitteratur. - 9789144076096 ; , s. 411-418
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Olsson, Ingrid, 1948
(författare)
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Ryggmärgsbråck(myelomeningocele)
- 2011
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Ingår i: Pediatrik eds. Moell C, Gustafsson Jl. - Stockholm : Liber. - 9789147093755 ; , s. 346-348
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Stigsdotter-Broman, Lina, et al.
(författare)
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Long-term follow-up after callosotomy : A prospective, population based, observational study
- 2014
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Ingår i: Epilepsia. - : Wiley. - 0013-9580 .- 1528-1167. ; 55:2, s. 316-321
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveAnalyze the long-term outcome of callosotomies with regard to seizure types and frequencies and antiepileptic drug treatment.MethodsThis longitudinal observational study is based on data from the prospective Swedish National Epilepsy Surgery Register. Thirty-one patients had undergone callosotomy in Sweden 1995-2007 and had been followed for 2 and 5 or 10years after surgery. Data on their seizure types and frequencies, associated impairments, and use of antiepileptic drugs have been analyzed.ResultsThe median total number of seizures per patient and month was reduced from 195 before surgery to 110 twoyears after surgery and 90 at the long-term follow-up (5 or 10years). The corresponding figures for drop attacks (tonic or atonic) were 190 before surgery, 100 2years after surgery, and 20 at the long-term follow-up. Ten (56%) of the 18 patients with drop attacks were free from drop attacks at long-term follow-up. Three of the remaining eight patients had a reduction of >75%. At long-term follow-up, four were off medication. Only one of the 31 patients had no neurologic impairment.SignificanceThe present population-based, prospective observational study shows that the corpus callosotomy reduces seizure frequency effectively and sustainably over the years. Most improvement was seen in drop attacks. The improvement in seizure frequency over time shown in this study suggests that callosotomy should be considered at an early age in children with intractable epilepsy and traumatizing drop attacks.
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| 8. |
- Uvebrant, Paul, 1951, et al.
(författare)
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Epilepsi
- 2012
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Ingår i: Barnmedicin, (red) K.Hanseus, H.Lagercrantz, T. Lindberg.. - Lund : Studentlitteratur. - 9789144076096 ; , s. 404-410
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Viggedal, Gerd, 1950, et al.
(författare)
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Cognitive development from two to ten years after pediatric epilepsy surgery.
- 2012
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Ingår i: Epilepsy & behavior : E&B. - : Elsevier BV. - 1525-5069. ; 25:1, s. 2-8
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Tidskriftsartikel (refereegranskat)abstract
- The development of cognitive functions and the sustainability of seizure control between two and ten years after epilepsy surgery were prospectively investigated in 17 children and adolescents. Intelligence quotient remained stable. Learning capacity improved. Verbal memory improved in half of the subjects and declined in half, whereas figurative memory declined in most patients. Working memory improved as did attention regarding sustained attention and impulse control. In contrast, reaction times were longer, and the auditory attention span was shorter. Executive functions were not affected. Six subjects (35%) were seizure free at the 10-year follow-up, and a seizure reduction of more than 75% had been achieved in 13 (76%). Seizure control improved in five and seizures recurred in two subjects between the two- and the 10-year follow-up.
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| 10. |
- Viggedal, Gerd, 1950, et al.
(författare)
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Intelligence two years after epilepsy surgery in children.
- 2013
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Ingår i: Epilepsy & Behavior. - : Elsevier BV. - 1525-5050. ; 29:3, s. 565-70
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Tidskriftsartikel (refereegranskat)abstract
- Intelligence before and two years after epilepsy surgery was assessed in 94 children and adolescents and related to preoperative IQ and seizure outcome. The median full-scale IQ was 70 before and two years after surgery. The proportion with a higher or unchanged postoperative IQ was 24 of 49 (49%) of those with an IQ of 70 and more before surgery, nine of 17 (53%) of those with an IQ of 50-69, and ten of 28 (36%) of those with an IQ of less than 50. A significant difference was found between the 47 individuals who became seizure-free and the 47 with persisting seizures, as 60% of the seizure-free children had a higher or unchanged IQ compared with 32% of the 47 who were not seizure-free. The cognitive outcome of children with intellectual disabilities was as good as that of children with average IQ. Thus, they should not be excluded from epilepsy surgery on the basis of low intellectual level.
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