| 1. |
- Ahlgren, L, et al.
(författare)
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Induced activity in a high-energy linear accelerator
- 1988
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Ingår i: Physics in Medicine and Biology. - : IOP Publishing. - 0031-9155 .- 1361-6560. ; 33:3, s. 4-351
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Tidskriftsartikel (refereegranskat)abstract
- Activation products which contribute significantly to the exposure of the staff operating the accelerator were found in the accelerator head in the transparent holder for the lead blocks and in the 60 degrees wedge filter made of lead. A proper choice of material in these parts of the accelerator could easily reduce this exposure without excessive changes in the construction. The absorbed dose-rate level should always be checked before maintenance is carried out inside the accelerator head.
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| 2. |
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| 3. |
- Fredrikson, G, et al.
(författare)
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Use of protein G for preparation and characterization of rabbit antibodies against rat adipose tissue hormone-sensitive lipase
- 1987
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Ingår i: Journal of Immunological Methods. - : Elsevier BV. - 0022-1759. ; 97:1, s. 65-70
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Tidskriftsartikel (refereegranskat)abstract
- The newly described immunoglobulin G-binding streptococcal surface protein, protein G, was used to prepare and characterize rabbit antibodies. The antibodies were directed against rat hormone-sensitive lipase, the rate-limiting enzyme in the hydrolysis of the triacylglycerols stored in adipose tissue. Antiserum was obtained after two injections with 20 micrograms enzyme protein, and the immunoglobulin fraction was obtained using a protein G-based solid-phase radioimmunoassay. The hydrolysis of acylglycerols by the enzyme was inhibited by the antibodies, and the enzyme could be efficiently removed from a solution using the antibodies and heat-killed streptococci expressing surface protein G. By Western blot and detection with 125I-protein G, the antibodies were found to selectively bind to hormone-sensitive lipase and to a smaller extent to two minor contaminants, possibly proteolytic fragments of the lipase. The amount of 125I-labelled protein G bound to the lipase on the blot was quantitatively related to the amount of enzyme protein down to the detection limit 10 ng.
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| 4. |
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| 5. |
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| 6. |
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| 7. |
- Landin-Olsson, M, et al.
(författare)
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Epidemiological and genetic aspects on islet autoimmunity in childhood insulin-dependent diabetes.
- 1988
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Ingår i: Genetic susceptibility to environmental factors : a challenge for public intervention : [First International Ernhold Lundström Symposium, Malmö, Sweden, May 14-16, 1987] - [First International Ernhold Lundström Symposium, Malmö, Sweden, May 14-16, 1987]. - 9122012621 ; , s. 87-93
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Bokkapitel (refereegranskat)
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| 8. |
- Landin-Olsson, M., et al.
(författare)
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Islet cell and other organ-specific autoantibodies in all children developing Type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children
- 1989
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Ingår i: Diabetologia. - 0012-186X. ; 32:6, s. 387-395
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Tidskriftsartikel (refereegranskat)abstract
- The majority (about 90%) of children developing Type 1 (insulin-dependent) diabetes mellitus do not have a first-degree relative with the disease. Nearly all (389/405, 96%) children (0-14 years) in Sweden, who developed diabetes during one year, were therefore studied to compare islet cell, thyroid peroxidase, thyroglobulin, and gastric H+, K+-ATPase antibodies with 321 age, sex, and geographically matched, but non-related, control children. Islet cell (cytoplasmic) antibodies were found in 81% (316/389) of the patients and in 3% (9/321) of the control children (p<0.001). The median islet cell antibody levels were 70 (range 3-8200) Juvenile Diabetes Foundation (JDF) Units in the islet cell antibody positive patients, and 27 (range 17-1200) JDF Units in the control children (NS). Autoantibodies against thyroid peroxidase (8%), thyroglobulin (6%), and gastric H+, K+- ATPase (3%) were all increased in the patients compared with the control children, being 2% (p<0.001), 2% (p<0.01), and 0.3% (p<0.01), respectively. During an observation time of 20-34 months, two of the nine islet cell antibody positive control children developed Type 1 diabetes, after 8 and 25 months respectively, while the others remained healthy and became islet cell antibody negative. None of the islet cell antibody negative control children developed diabetes during the same time of observation. This first investigation of an unselected population of diabetic children and matched control children shows: that islet cell antibodies are strongly associated with newly diagnosed childhood diabetes, that other autoantibodies are more frequent among diabetic children than control children, and that the frequency of islet cell antibodies in the background population of children is higher than previously documented, and could also be transient, underlining that factors additional to islet cell antibodies are necessary for the later development of Type 1 diabetes.
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| 9. |
- Larsson, L, et al.
(författare)
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The measurement of cell growth in coal slurries
- 1989
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Ingår i: Biotechnology Techniques. - 0951-208X. ; 3:5, s. 295-298
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Tidskriftsartikel (refereegranskat)abstract
- Microbial growth in coal slurries can be detected if surfactant is present in the samples by analysing the protein concentration after disintegration of the cells. Without surfactant present in the samples, the proteins are readily adsorbed on the coal surfaces. A suitable surfactant is sodium dodecyl sulphate at 0.5 to 1% of the sample volume
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