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- South, Nicholas, et al.
(författare)
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Väderradarteknik inom VA-området : Test av metodik
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The report consists of a literature study of X-band weather radar technology, a comparison of rain data between an X-band radar facility near Lund and rain gauges, an analysis of flow- and sewage overflow data during rain events and implementation ideas of the X-band radar.
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- Bexelius, Maria, et al.
(författare)
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27 forskare : Så kan EU:s murar rivas
- 2015
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Ingår i: Dagens samhälle. - : Sveriges kommuner och landsting. - 1652-6511. ; :20150923
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Tidskriftsartikel (populärvet., debatt m.m.)
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- Christiansson, Lisa, et al.
(författare)
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The Tyrosine Kinase Inhibitors Imatinib and Dasatinib Reduce Myeloid Suppressor Cells and Release Effector Lymphocyte Responses
- 2015
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Ingår i: Molecular Cancer Therapeutics. - : American Association for Cancer Research. - 1535-7163 .- 1538-8514. ; 14:5, s. 1181-1191
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Tidskriftsartikel (refereegranskat)abstract
- Immune escape mechanisms promote tumor progression and are hurdles of cancer immunotherapy. Removing immunosuppressive cells before treatment can enhance efficacy. Tyrosine kinase inhibitors (TKI) may be of interest to combine with immunotherapy, as it has been shown that the inhibitor sunitinib reduces myeloid suppressor cells in patients with renal cell carcinoma and dasatinib promotes expansion of natural killer-like lymphocytes in chronic myeloid leukemia (CML). In this study, the capacity of dasatinib and imatinib to reduce myeloid suppressor cells and to induce immunomodulation in vivo was investigated ex vivo. Samples from CML patients treated with imatinib (n = 18) or dasatinib (n = 14) within a Nordic clinical trial (clinicalTrials.gov identifier: NCT00852566) were investigated for the presence of CD11b(+)CD14(-)CD33(+) myeloid cells and inhibitorymolecules (arginase I, myeloperoxidase, IL10) as well as the presence of natural killer cells, T cells (naive/memory), and stimulatory cytokines (IL12, IFN gamma, MIG, IP10). Both imatinib and dasatinib decreased the presence of CD11b(+)CD14(-)CD33(+) myeloid cells as well as the inhibitory molecules and the remaining myeloid suppressor cells had an increased CD40 expression. Monocytes also increased CD40 after therapy. Moreover, increased levels of CD40, IL12, natural killer cells, and experienced T cells were noted after TKI initiation. The presence of experienced T cells was correlated to a higher IFNg and MIG plasma concentration. Taken together, the results demonstrate that both imatinib and dasatinib tilted the immunosuppressive CML tumor milieu towards promoting immune stimulation. Hence, imatinib and dasatinib may be of interest to combine with cancer immunotherapy. (C) 2015 AACR.
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- Falck, Anna-Karin, et al.
(författare)
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St Gallen molecular subtypes in screening-detected and symptomatic breast cancer in a prospective cohort with long-term follow-up.
- 2016
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Ingår i: British Journal of Surgery. - : Oxford University Press (OUP). - 1365-2168 .- 0007-1323. ; 103:5, s. 513-523
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Tidskriftsartikel (refereegranskat)abstract
- Diagnosis by screening mammography is considered an independent positive prognostic factor, although the data are not fully in agreement. The aim of the study was to explore whether the mode of detection (screening-detected versus symptomatic) adds prognostic information to the St Gallen molecular subtypes of primary breast cancer, in terms of 10-year cumulative breast cancer mortality (BCM).
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- Francke, Helena, et al.
(författare)
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Author Perspectives on Research Visibility and Impact
- 2018
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Ingår i: 23rd Nordic Workshop on Bibliometrics and Research Policy 2018.
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Konferensbidrag (refereegranskat)abstract
- The poster will present findings from a survey of 375 corresponding authors whose publications have beenpublished open access as part of the Springer Compact agreement between Bibsam and Springer Nature 2016-2018. In focus is how these authors reason about ways to make their research visible, how/if they themselves tryto track the attention gained by the publication, and what they think are good impact measures. The study thusadds to previous work on author attitudes and practices (e.g. Hammarfelt & Haddow, 2018; Tenopir et al., 2016)and can provide some input into the current work in Sweden on how to evaluate and assure high research quality(UKÄ, 2018).When asked about their arguments for publishing open access, a large proportion of respondents in freetextanswers indicated that open access is important because it increases a publication’s visibility, access to it,downloads and/or social and scientific impact. Consequently, it is interesting to investigate if open accesspublishing is the only way in which these authors try to find readers for their publication, or if they take furthersteps. Answers suggest researchers use general social media, academic networking sites, and more traditionaldigital channels to share their publications.Furthermore, the study asked which measures the authors think are the best ones for assessing the impactof their publications, and how they themselves find out how much attention their publications get. The responseswill be discussed in terms of traditional metrics, such as JIFs and citations, and altmetrics, such as how documentsare accessed or appraised (Haustein et al., 2016) through downloads or shares in social media. They will also berelated to more indirect forms of research evaluation, such as peer review and social impact.ReferencesHammarfelt, B. & Haddow, G. (2018). Conflicting measures and values: How humanities scholars in Australia and Swedenuse and react to bibliometric indicators. JASIS&T, 69(7), 924-935.Haustein, S., Bowman, T. D. & Costas, R. (2016). Interpreting ‘altmetrics’: Viewing acts on social media through the lensof citation and social theories. In Sugimoto, C. R. (Ed.), Theories of informetrics and scholarly communication (pp. 372-405). Berlin: De Gruyter Mouton.Tenopir, C. et al. (2016). No scholar is an island: The impact of sharing in the work life of scholars. Learned Publishing, 30,5-17.UKÄ - Universitetskanslerämbetet (2018). Kvalitetssäkring av forskning: Rapportering av ett regeringsuppdrag. (Report2018:2) Stockholm: Universitetskanslerämbetet.
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- George, Cindy, et al.
(författare)
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The association between high-sensitivity c-reactive protein and metabolic risk factors in black and white South African women : a cross-sectional study
- 2018
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Ingår i: BMC Obesity. - : BioMed Central (BMC). - 2052-9538. ; 5:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: High-sensitivity C-reactive protein (hsCRP) is associated with metabolic risk, however it is unclear whether the relationship is confounded by racial/ethnic differences in socioeconomic status (SES), lifestyle factors or central adiposity. The aims of the study was, (1) to investigate whether hsCRP levels differ by race/ethnicity; (2) to examine the race/ethnic-specific associations between hsCRP, HOMA-IR and serum lipids [total cholesterol (TC), triglycerides (TG), high-density lipoproteins (HDL-C) and low-density lipoproteins (LDL-C)]; and (3) to determine whether race/ethnic-specific associations are explained by SES, lifestyle factors or waist circumference (WC).Methods: The convenience sample comprised 195 black and 153 white apparently health women, aged 18-45 years. SES (education, assets and housing density) and lifestyle factors (alcohol use, physical activity and contraceptive use) were collected by questionnaire. Weight, height and WC were measured, and fasting blood samples collected for hsCRP, glucose, insulin, and lipids.Results: Black women had higher age- and BMI-adjusted hsCRP levels than white women (p=0.047). hsCRP was associated with HOMA-IR (p<0.001), TG (p<0.001), TC (p<0.05), HDL-C (p<0.05), and LDL-C (p<0.05), independent of age and race/ethnicity. The association between hsCRP and lipids differed by race/ethnicity, such that hsCRP was positively associated with TG and LDL-C in white women, and inversely associated with HDL-C in black women. Higher hsCRP was also associated with higher TC in white women and lower TC in black women. Furthermore, when adjusting for SES and lifestyle factors, the associations between hsCRP, and TC and TG, remained, however the associations between hsCRP, and HDL-C and LDL-C, were no longer significant.Conclusion: Although circulating hsCRP may identify individuals at increased metabolic risk, the heterogeneity in these associations between racial/ethnic groups highlights the need for prospective studies investigating the role of hsCRP for risk prediction in different populations.
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