| 1. |
- Christie, M., et al.
(författare)
-
Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes
- 1988
-
Ingår i: Diabetologia. - 0012-186X. ; 31:8, s. 597-602
-
Tidskriftsartikel (refereegranskat)abstract
- Sera from 40 Swedish children diagnosed as having Type 1 (insulin-dependent) diabetes mellitus during a one year period along with 40 age and geographically matched control subjects were tested for antibodies to a Mr-64000 islet protein by immunoprecipitation of 35S-methionine-labelled rat islet amphiphilic proteins. Of the 40 diabetic patients, 29 (73%) were found to be positive whereas all 40 control subjects were negative. Samples were also tested for titres of islet cell cytoplasmic antibodies by indirect immunofluorescence on frozen sections of human pancreas. In the diabetic group, 30 of the 40 patients (75%) were positive for islet cell cytoplasmic antibodies compared with 2 of the 40 control subjects (5%). A comparison of levels of antibodies to the Mr-64000 protein with islet cell cytoplasmic antibodies revealed a weak (rs=0.46), but significant (p<0.01) correlation between the two tests. There was no effect of age or sex on levels of antibodies to the Mr-64000 protein. These results in population-based diabetic children and control subjects demonstrate a high frequency of antibodies to the Mr-64000 protein at the time of clinical onset.
|
|
| 2. |
|
|
| 3. |
- Olsson, H., et al.
(författare)
-
Relation between tumour size and plasma prolactin levels in premenopausal patients with breast carcinoma : A preliminary report
- 1985
-
Ingår i: Acta Radiologica: Oncology. - : Informa UK Limited. - 0349-652X. ; 24:1, s. 57-59
-
Tidskriftsartikel (refereegranskat)abstract
- In thirty-one premenopausal patients with carcinoma of the breast the plasma prolactin was measured after mastectomy. A highly significant correlation between tumour size and plasma prolactin levels (p<0.002) was observed after adjustment for age at diagnosis and parity. At the time of the prolactin determination no clinical signs of metastatic disease were evident, suggesting that the prolactinc levels were unrelated to the tumour burden.
|
|
| 4. |
- Olsson, H., et al.
(författare)
-
Retrospective assessment of menstrual cycle length in patients with breast cancer, in patients with benign breast disease, and in women without breast disease
- 1983
-
Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 70:1, s. 17-20
-
Tidskriftsartikel (refereegranskat)abstract
- The length of the menstrual cycle was compared in women with breast cancer, women with benign breast disease, and controls. Older women in general tended to report shorter menstrual cycles (P < 0.05). After correction for the age difference, breast cancer patients still reported a shorter average menstrual cycle length than benign breast disease patients and controls (P < 0.006). Very short cycles (≤21 days) were present in 20% of the breast cancer patients compared to 8% of the patients with benign breast disease and 4% of the controls (P < 0.0001). Long cycles (≥30 days) were not a feature of breast cancer patients (2%), whereas 20% of the patients with benign breast disease and 28% of the controls reported such long cycles (P < 0.0001). Irregular menstrual cycles were more common in benign breast disease patients (20%) than in cancer patients (10%) and controls (8%) (P < 0.001).
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Blomström-Lundqvist, Carina, et al.
(författare)
-
Effect of long term treatment with metoprolol and sotalol on ventricular repolarisation measured by use of transoesophageal atrial pacing
- 1986
-
Ingår i: British Heart Journal. - 0007-0769. ; 55:2, s. 181-186
-
Tidskriftsartikel (refereegranskat)abstract
- The effects of long term (4 weeks) treatment with oral metoprolol (100 mg twice daily) and sotalol (160 mg twice daily) on ventricular repolarisation time were compared in a double blind crossover study in 20 patients post-infarction. For QT interval studies transoesophageal atrial pacing was performed at a cycle length of 800 ms. Sotalol prolonged the QT interval by 5-7% compared with metoprolol. The prolongation reflects a change in the repolarisation time because there was no change in the QS interval. Measurements of heart rate at rest and during bicycle exercise indicated that metoprolol and sotalol in the doses selected were equipotent as beta blockers. Transoesophageal atrial pacing is a simple non-invasive method with few and mild side effects that is well suited to drug studies.
|
|
| 8. |
- Blomström-Lundqvist, C, et al.
(författare)
-
Ventricular dimensions and wall motion assessed by echocardiography in patients with arrhythmogenic right ventricular dysplasia
- 1988
-
Ingår i: European Heart Journal. - 0195-668X .- 1522-9645. ; 9:12, s. 1291-1302
-
Tidskriftsartikel (refereegranskat)abstract
- Twenty patients with arrhythmogenic right ventricular dysplasia (ARVD) and 20 healthy volunteers underwent cross-sectional echocardiographic examination for the assessment of ventricular dimensions and wall motion. Right ventricular cavity diameters and wall segments were selected from the inflow and outflow tracts and the right ventricular body. The measurement error for measuring cavity dimensions was low throughout and the reproducibility of wall motion scoring was high in both the normal subjects and the patients. All except one patient had increased dimensions and/or abnormal wall motion in the right ventricle. The right ventricular inflow tract was dilated in nine patients, the outflow tract in 11 patients and the short- or long-axis diameters of the right ventricular body were increased in seven patients. Right ventricular wall motion abnormalities, being the most frequent finding, ranged from mild hypokinesia only to dyskinesia or sacculations, and were fairly evenly distributed among the segments studied. Left ventricular abnormalities, found in eight patients, were generally mild. Cross-sectional echocardiography thus provides highly reproducible measurements of right ventricular size and contraction patterns even in patients with wall shape deformities, and is therefore a feasible non-invasive method for the evaluation of right-sided myocardial abnormalities in patients with ARVD. The diagnostic accuracy of this technique warrants further clarification.
|
|
| 9. |
- Brandt, L., et al.
(författare)
-
Uptake of thymidine in lymphoma cells obtained through fine-needle aspiration biopsy. Relation to prognosis in non-hodgkin's lymphomas
- 1981
-
Ingår i: European Journal of Cancer and Clinical Oncology. - 0277-5379. ; 17:11, s. 1229-1233
-
Tidskriftsartikel (refereegranskat)abstract
- In vitro uptake of tritiated thymidine was studied in autoradiographic preparations of lymphoma cell suspensions obtained through fine-needle aspiration biopsy from 28 patients with non-Hodgkin's lymphoma. The labelling indices (LI ) were highest in patients with histiocytic or poorly differentiated lymphocytic lymphoma. During a two-year period there was a significant correlation between LI and survival, i.e., high LI were associated with a poor prognosis. The results indicate that, in addition to morphology, estimation of the proliferative activity of lymphoma cells may be of clinical significance. © 1981, Pergamon Press Ltd.. All rights reserved.
|
|
| 10. |
|
|
