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- Holmes, Michael V., et al.
(författare)
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Secretory Phospholipase A(2)-IIA and Cardiovascular Disease
- 2013
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Ingår i: Journal of the American College of Cardiology. - : Elsevier. - 0735-1097 .- 1558-3597. ; 62:21, s. 1966-1976
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Tidskriftsartikel (refereegranskat)abstract
- Objectives This study sought to investigate the role of secretory phospholipase A(2) (sPLA(2))-IIA in cardiovascular disease. less thanbrgreater than less thanbrgreater thanBackground Higher circulating levels of sPLA(2)-IIA mass or sPLA(2) enzyme activity have been associated with increased risk of cardiovascular events. However, it is not clear if this association is causal. A recent phase III clinical trial of an sPLA(2) inhibitor (varespladib) was stopped prematurely for lack of efficacy. less thanbrgreater than less thanbrgreater thanMethods We conducted a Mendelian randomization meta-analysis of 19 general population studies (8,021 incident, 7,513 prevalent major vascular events [MVE] in 74,683 individuals) and 10 acute coronary syndrome (ACS) cohorts (2,520 recurrent MVE in 18,355 individuals) using rs11573156, a variant in PLA2G2A encoding the sPLA(2)-IIA isoenzyme, as an instrumental variable. less thanbrgreater than less thanbrgreater thanResults PLA2G2A rs11573156 C allele associated with lower circulating sPLA(2)-IIA mass (38% to 44%) and sPLA(2) enzyme activity (3% to 23%) per C allele. The odds ratio (OR) for MVE per rs11573156 C allele was 1.02 (95% confidence interval [CI]: 0.98 to 1.06) in general populations and 0.96 (95% CI: 0.90 to 1.03) in ACS cohorts. In the general population studies, the OR derived from the genetic instrumental variable analysis for MVE for a 1-log unit lower sPLA(2)-IIA mass was 1.04 (95% CI: 0.96 to 1.13), and differed from the non-genetic observational estimate (OR: 0.69; 95% CI: 0.61 to 0.79). In the ACS cohorts, both the genetic instrumental variable and observational ORs showed a null association with MVE. Instrumental variable analysis failed to show associations between sPLA2 enzyme activity and MVE. less thanbrgreater than less thanbrgreater thanConclusions Reducing sPLA(2)-IIA mass is unlikely to be a useful therapeutic goal for preventing cardiovascular events.
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| 2. |
- Emaus, Marleen J., et al.
(författare)
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Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study
- 2014
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 135:12, s. 2887-2899
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Tidskriftsartikel (refereegranskat)abstract
- Long-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40-50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition cohort, with information on anthropometric measures at recruitment and after a median follow-up of 4.3 years. Annual weight change was categorized using quintiles taking quintile 2 and 3 as the reference category (-0.44 to 0.36 kg/year). Multivariable Cox proportional hazards regression analysis was used to examine the association. 205,723 women were included and 4,663 incident breast cancer cases were diagnosed during a median follow-up of 7.5 years (from second weight assessment onward). High weight gain (Q5: 0.83-4.98 kg/year) was related to a slightly, but significantly higher breast cancer risk (HRQ5_versus_Q2/3: 1.09, 95% CI: 1.01-1.18). The association was more pronounced for breast cancer diagnosed before or at age 50 (HRQ5_versus_Q2/3: 1.37, 95% CI: 1.02-1.85). Weight loss was not associated with breast cancer risk. There was no evidence for heterogeneity by hormone receptor status. In conclusion, high weight gain in middle adulthood increases the risk of breast cancer. The association seems to be more pronounced for breast cancer diagnosed before or at age 50. Our results illustrate the importance of avoiding weight gain in middle adulthood.
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| 4. |
- Arakelyan, Arsen, et al.
(författare)
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Functional Genetic Polymorphisms of Monocyte Chemoattractant Protein 1 and C-C Chemokine Receptor Type 2 in Ischemic Stroke
- 2014
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Ingår i: Journal of Interferon and Cytokine Research. - New Rochelle, NY : Mary Ann Liebert. - 1079-9907 .- 1557-7465. ; 34:2, s. 100-105
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Tidskriftsartikel (refereegranskat)abstract
- Recent findings indicated that monocyte chemoattractant protein 1 (MCP1) and its C-C chemokine receptor type 2 (CCR2) play a key role in ischemic stroke (IS) progression. This study was aimed at evaluating the potential association of the MCP1 gene (MCP1) rs1024611 (-2518 A>G) and CCR2 gene (CCR2) rs1799864 (V64I; 190 G>A) functional single nucleotide polymorphisms (SNPs) with IS in the Armenian population. For the purpose of this study, genomic DNA samples of 100 patients with the first-episode IS and 115 healthy subjects (controls) were genotyped for the selected SNPs using a polymerase chain reaction with sequence-specific primers. The results obtained demonstrated that while the CCR2 rs1799864 SNP genotypes were equally distributed among patients and controls, the frequency and carriage rate of the of the MCP1 rs1024611*G minor allele were higher in patients. While a potential association between IS and CCR2 rs1799864 SNP was evaluated for the first time, the latest finding was in agreement with the earlier data reported for some other populations. In summary, this study revealed no association of CCR2 rs1799864 SNP with IS, and a positive association between G minor allele of MCP1 rs1024611 SNP and IS in the Armenian population. Based on the present and earlier reported data, we concluded that the minor G allele of the MCP1 rs1024611 SNP might be considered a risk factor for IS.
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| 5. |
- Brorsson, Sofia, et al.
(författare)
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Maximal multiple repetitions in free weight strength training with different bar sizes
- 2010
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Konferensbidrag (refereegranskat)abstract
- INTRODUCTION: An individual’s grip strength is vital for performance of physical demanding tasks such as give some other example here? As well as strength training with free weights. Performing strength training with a thicker grip around the bar may enhance the strength of the grip in the athlete without other special routines for grip strength development. The purpose of this study was a) to examine the difference in performance in multiple repetitions in two strength training exercises using two different sizes on the bar, b) to investigate correlations between hand grip strength and the amount of repetitions performed with two different sizes of the bar and c) to correlate hand size with the amount of performed repetitions with two different bar sizes.METHODS: Fifteen male participants (24 ± 4 years) with at least one year of strength training experience performed bench press and a prone lying rowing exercise with two different bar sizes (normal Olympic lifting bar with and with out Fat Gripz™). The participants performed test of maximal number of repetitions at a level of 80% of one repetition maximum (1RM), hand size was measured as well as maximum grip strength (using JAMAR).RESULTS: The use of a thicker diameter bar resulted in 22 % (p<0.01) reduction of weight performance in number of performed repetitions in the bench press compared to the normal diameter of the bar. When performing lying bench row a 66 % (p<0.01) reduction in number of performed repetitions was seen with the thicker diameter of the bar. There was no significant correlation between hand size and the submaximal strength test (rp = 0,33 ; p = 0,23) or grip strength and submaximal strength test (rp = 0,31 ; p = 0,27).CONCLUSION: The results from this study indicated that the size of the bar diameter influences the performance in maximal number of repetitions in a prone lying rowing exercise and bench press. Further studies have to be done to analyses the effect of strength training with thicker bar.
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| 6. |
- Brorsson, Sofia, et al.
(författare)
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Maximal strength in one leg squat correlates with acceleration capacity and agility
- 2010
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Konferensbidrag (refereegranskat)abstract
- INTRODUCTION: In many intermittent team sports capacities such as speed, agility and explosiveness are important for performance and are evaluated by sprint-, agility- and strength tests. Earlier studies have shown strong correlations between strength in the two leg squat exercise and sprint performance in various distances but not in sprint performance in agility. Studies evaluating squat strength predominantly perform tests on two legs even when they test athletes involved in intermittent sports where sprinting and agility are common features. Thus, the purpose of this study was to investigate the correlation between maximal strength in a one leg squat (Bulgarian split squat) and acceleration capacity in various sprint distances and agility.METHODS: The test group consisted of 19 men (mean age 24 ± 2 years ) with experience in intermittent team sports. Acceleration capacity was assessed by sprint tests at 5, 10 and 20 meters and agility was evaluated using the zigzag agility test. The timing was made using photocells (Muscle lab,Ergotest Technology,Norway). The Bulgarian split squat was performed in a smith machine with the barbell on the shoulders to a depth of 110 degrees between tibia and femur.RESULTS: The results show significant correlation between maximal strength in the Bulgarian split squat and sprint capacity in the 5 and 10 meter sprint test (Rp= -0,56; p<0.01) as well as the agility test. Maximal strength relative to bodyweight showed significant correlation with the 5 and 20 meter sprint (Rp=-0,62; p< 0,01) as well as the agility test. The zigzag agility test also showed significant correlation between all distances in the sprint tests (p<0.01).CONCLUSION: The results from this study show that there maximal strength in one leg correlate significantly with both acceleration capacity and agility. Implementing one leg exercises in the strength and conditioning routine can be useful for athletes in intermittent sports wanting to improve agility and short sprinting capacity. Further implications is that the Bulgarian split squat could be a more functional test for agility performance than the squat on two legs which predominantly is being used today.
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| 7. |
- Brorsson, Sofia, et al.
(författare)
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Training program for young female soccer players with focus on increasing the acceleration capacity
- 2010
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Konferensbidrag (refereegranskat)abstract
- INTRODUCTION: Soccer is the world’s most popular team sport with over 240 million players around the world. About 20 million of the 240 million players are women and 80% of these women are adolescence or juniors. Acceleration capacity is one of the most important physical qualities for a soccer player. The aim of this study was to design, perform and evaluate a training program for young female soccer players with focus on increasing the acceleration capacity.METHODS: There were 22 young females (14,6 ± 1,0 years, 50,3 ± 5,1 kg, 160,2 ± 3,0 cm) from two different soccer teams participating. They were split into two groups, one test group (TG) (n=8) and one control group (CG) (n=14). The training period was 12 weeks, with soccer training 3 times per week for both groups. In the TG one workout per week was specifically designed to increase the acceleration capacity and took about 40 minutes to perform. The acceleration capacity was evaluated by a sprint test of 10-20-30 meter and vertical countermovement jump test using photocells. RESULTS: The TG showed a tendency to increased acceleration at the sprint test (p=0,08) and significant improvement at the jump test (p<0.05) after 12 weeks of training. The acceleration training also showed significant correlations between the sprint- and jump test in the TG after completed the 12 week training period (p<0.05). The CG showed decreased acceleration at the sprint test (p<0.05) and the vertical jump height was not significantly different. There were no significant differences between the two groups pre and post training.CONCLUSION: A 12 week training program can increase the acceleration capacity and the vertical jump height on young female soccer players. In sport were acceleration capacity is important it seems relevant to specifically train those qualities.
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