| 1. |
- Field, Christopher B., et al.
(författare)
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Summary for Policymakers
- 2014
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Ingår i: Climate Change 2014: Impacts, Adaptation, and Vulnerability. Part A: Global and SectoralAspects.. - 9781107415379 ; , s. 1-32
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Bokkapitel (refereegranskat)
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| 2. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 6. |
- Ahlsson, Fredrik, et al.
(författare)
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Insulin Resistance, a Link between Maternal Overweight and Fetal Macrosomia in Nondiabetic Pregnancies
- 2010
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Ingår i: Hormone research in paediatrics. - : S. Karger AG. - 1663-2818 .- 1663-2826. ; 74:4, s. 267-274
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Tidskriftsartikel (refereegranskat)abstract
- Background/Aims: During the last decades the number of large for gestational age infants delivered by nondiabetic mothers has increased. Our aim was to investigate to what extent fetal growth in nondiabetic pregnant women can be explained by rates of maternal energy substrate production and resting energy expenditure. Methods: Twenty nonsmoking pregnant women without impaired glucose tolerance and with a wide range of fetal weights (0.2-2.7 SDS) were investigated at 36 weeks of gestation. Maternal lipolysis, glucose production, resting energy expenditure, body composition and insulin resistance were assessed.Results: Median (range) glucose production rate was 805 (653-1,337) mumol/min and that of glycerol, reflecting lipolysis, was 214 (110-576) mumol/min. Multiple linear regression analysis showed that maternal fat mass explained 36% of the variation in insulin resistance, accounting for 62% of the variation in glucose production. Further, glucose production explained 31% of the variation in fetal weight. Resting energy expenditure explained 51% of the variation in estimated fetal weight. Conclusion: Fetal weight is dependent on maternal glucose production, which is in turn determined by the degree of insulin resistance, induced in part by the maternal fat mass. The variation in maternal resting energy expenditure is closely related to fetal weight.
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| 7. |
- Ahmad, Waqas, et al.
(författare)
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Compression scheme for sparsely sampled light field data based on pseudo multi-view sequences
- 2018
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Ingår i: OPTICS, PHOTONICS, AND DIGITAL TECHNOLOGIES FOR IMAGING APPLICATIONS V Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE - International Society for Optical Engineering.
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Konferensbidrag (refereegranskat)abstract
- With the advent of light field acquisition technologies, the captured information of the scene is enriched by having both angular and spatial information. The captured information provides additional capabilities in the post processing stage, e.g. refocusing, 3D scene reconstruction, synthetic aperture etc. Light field capturing devices are classified in two categories. In the first category, a single plenoptic camera is used to capture a densely sampled light field, and in second category, multiple traditional cameras are used to capture a sparsely sampled light field. In both cases, the size of captured data increases with the additional angular information. The recent call for proposal related to compression of light field data by JPEG, also called “JPEG Pleno”, reflects the need of a new and efficient light field compression solution. In this paper, we propose a compression solution for sparsely sampled light field data. In a multi-camera system, each view depicts the scene from a single perspective. We propose to interpret each single view as a frame of pseudo video sequence. In this way, complete MxN views of multi-camera system are treated as M pseudo video sequences, where each pseudo video sequence contains N frames. The central pseudo video sequence is taken as base View and first frame in all the pseudo video sequences is taken as base Picture Order Count (POC). The frame contained in base view and base POC is labeled as base frame. The remaining frames are divided into three predictor levels. Frames placed in each successive level can take prediction from previously encoded frames. However, the frames assigned with last prediction level are not used for prediction of other frames. Moreover, the rate-allocation for each frame is performed by taking into account its predictor level, its frame distance and view wise decoding distance relative to the base frame. The multi-view extension of high efficiency video coding (MV-HEVC) is used to compress the pseudo multi-view sequences. The MV-HEVC compression standard enables the frames to take prediction in both direction (horizontal and vertical d), and MV-HEVC parameters are used to implement the proposed 2D prediction and rate allocation scheme. A subset of four light field images from Stanford dataset are compressed, using the proposed compression scheme on four bitrates in order to cover the low to high bit-rates scenarios. The comparison is made with state-of-art reference encoder HEVC and its real-time implementation X265. The 17x17 grid is converted into a single pseudo sequence of 289 frames by following the order explained in JPEG Pleno call for proposal and given as input to the both reference schemes. The rate distortion analysis shows that the proposed compression scheme outperforms both reference schemes in all tested bitrate scenarios for all test images. The average BD-PSNR gain is 1.36 dB over HEVC and 2.15 dB over X265.
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| 8. |
- Ahmad, Waqas, et al.
(författare)
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Computationally Efficient Light Field Image Compression Using a Multiview HEVC Framework
- 2019
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Ingår i: IEEE Access. - 2169-3536. ; 7, s. 143002-143014
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Tidskriftsartikel (refereegranskat)abstract
- The acquisition of the spatial and angular information of a scene using light eld (LF) technologies supplement a wide range of post-processing applications, such as scene reconstruction, refocusing, virtual view synthesis, and so forth. The additional angular information possessed by LF data increases the size of the overall data captured while offering the same spatial resolution. The main contributor to the size of captured data (i.e., angular information) contains a high correlation that is exploited by state-of-the-art video encoders by treating the LF as a pseudo video sequence (PVS). The interpretation of LF as a single PVS restricts the encoding scheme to only utilize a single-dimensional angular correlation present in the LF data. In this paper, we present an LF compression framework that efciently exploits the spatial and angular correlation using a multiview extension of high-efciency video coding (MV-HEVC). The input LF views are converted into multiple PVSs and are organized hierarchically. The rate-allocation scheme takes into account the assigned organization of frames and distributes quality/bits among them accordingly. Subsequently, the reference picture selection scheme prioritizes the reference frames based on the assigned quality. The proposed compression scheme is evaluated by following the common test conditions set by JPEG Pleno. The proposed scheme performs 0.75 dB better compared to state-of-the-art compression schemes and 2.5 dB better compared to the x265-based JPEG Pleno anchor scheme. Moreover, an optimized motionsearch scheme is proposed in the framework that reduces the computational complexity (in terms of the sum of absolute difference [SAD] computations) of motion estimation by up to 87% with a negligible loss in visual quality (approximately 0.05 dB).
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| 9. |
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| 10. |
- Ahmad, Waqas, et al.
(författare)
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Interpreting Plenoptic Images as Multi-View Sequences for Improved Compression
- 2017
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Ingår i: ICIP 2017. - : IEEE. - 9781509021758 ; , s. 4557-4561
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Konferensbidrag (refereegranskat)abstract
- Over the last decade, advancements in optical devices have made it possible for new novel image acquisition technologies to appear. Angular information for each spatial point is acquired in addition to the spatial information of the scene that enables 3D scene reconstruction and various post-processing effects. Current generation of plenoptic cameras spatially multiplex the angular information, which implies an increase in image resolution to retain the level of spatial information gathered by conventional cameras. In this work, the resulting plenoptic image is interpreted as a multi-view sequence that is efficiently compressed using the multi-view extension of high efficiency video coding (MV-HEVC). A novel two dimensional weighted prediction and rate allocation scheme is proposed to adopt the HEVC compression structure to the plenoptic image properties. The proposed coding approach is a response to ICIP 2017 Grand Challenge: Light field Image Coding. The proposed scheme outperforms all ICME contestants, and improves on the JPEG-anchor of ICME with an average PSNR gain of 7.5 dB and the HEVC-anchor of ICIP 2017 Grand Challenge with an average PSNR gain of 2.4 dB.
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