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Healthy Nordic Diet...
Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome-A SYSDIET Sub-Study
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- Myhrstad, Mari C. W. (författare)
- Oslo Metropolitan Univ, Fac Hlth Sci, Dept Nursing & Hlth Promot, N-0130 Oslo, Norway,Oslo Metropolitan University,University of Eastern Finland
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- de Mello, Vanessa D. (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland,University of Eastern Finland
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- Dahlman, Ingrid (författare)
- Karolinska Institutet,Karolinska Institute
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- Kolehmainen, Marjukka (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland,University of Eastern Finland
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- Paananen, Jussi (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland,University of Eastern Finland
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- Rundblad, Amanda (författare)
- Univ Oslo, Inst Basic Med Sci, Dept Nutr, N-0316 Oslo, Norway,University of Oslo
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- Carlberg, Carsten (författare)
- Univ Eastern Finland, Inst Biomed, Kuopio 70211, Finland
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- Olstad, Ole Kristoffer (författare)
- Oslo Univ Hosp, Dept Med Biochem, N-0424 Oslo, Norway,Oslo university hospital
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- Pihlajamaki, Jussi (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland;Kuopio Univ Hosp, Dept Med Endocrinol & Clin Nutr, Kuopio 70029, Finland,Kuopio University Hospital,University of Eastern Finland
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- Holven, Kirsten B. (författare)
- Univ Oslo, Inst Basic Med Sci, Dept Nutr, N-0316 Oslo, Norway;Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Norwegian Natl Advisory Unit Familial Hypercholes, N-0424 Oslo, Norway,University of Oslo,Oslo university hospital
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- Hermansen, Kjeld (författare)
- Aarhus Univ Hosp, Dept Endocrinol & Internal Med, DK-8200 Aarhus, Denmark,Aarhus University Hospital
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- Dragsted, Lars O. (författare)
- Univ Copenhagen, Dept Nutr Exercise & Sports, Fac Sci, DK-2200 Copenhagen N, Denmark,University of Copenhagen
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- Gunnarsdottir, Ingibjoerg (författare)
- Univ Iceland, Unit Nutr Res, IS-101 Reykjavik, Iceland;Landspitali Natl Univ Hosp Iceland, IS-101 Reykjavik, Iceland,National University Hospital of Iceland
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- Cloetens, Lieselotte (författare)
- Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Storm, Matilda Ulmius (författare)
- Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Åkesson, Björn (författare)
- Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Skåne University Hospital
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- Rosqvist, Fredrik, 1985- (författare)
- Uppsala University,Uppsala universitet,Klinisk nutrition och metabolism
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- Hukkanen, Janne (författare)
- Univ Oulu, Dept Internal Med, Oulu 90014, Finland;Univ Oulu, Bioctr Oulu, Oulu 90014, Finland;Oulu Univ Hosp, Med Res Ctr, Oulu 90014, Finland,Oulu University Hospital,University of Oulu
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- Herzig, Karl-Heinz (författare)
- Univ Oulu, MRC, Inst Biomed, Oulu 90014, Finland;Univ Oulu, MRC, Bioctr Oulu, Oulu 90014, Finland;Univ Hosp, Oulu 90014, Finland;Poznan Univ Med Sci, Dept Gastroenterol & Metab, PL-1061701 Poznan, Poland,Poznan University of Medical Sciences,Oulu University Hospital,University of Oulu
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- Risérus, Ulf, 1967- (författare)
- Uppsala University,Uppsala universitet,Klinisk nutrition och metabolism
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- Thorsdottir, Inga (författare)
- Univ Iceland, Unit Nutr Res, IS-101 Reykjavik, Iceland;Landspitali Natl Univ Hosp Iceland, IS-101 Reykjavik, Iceland,National University Hospital of Iceland
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- Poutanen, Kaisa S. (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland;VTT Tech Res Ctr Finland, Espoo 02044, Finland,University of Eastern Finland,VTT Technical Research Center of Finland, Espoo
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- Savolainen, Markku J. (författare)
- Univ Oulu, Dept Internal Med, Oulu 90014, Finland;Univ Oulu, Bioctr Oulu, Oulu 90014, Finland;Oulu Univ Hosp, Med Res Ctr, Oulu 90014, Finland,Oulu University Hospital,University of Oulu
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- Schwab, Ursula (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland;Kuopio Univ Hosp, Dept Med Endocrinol & Clin Nutr, Kuopio 70029, Finland,University of Eastern Finland,Kuopio University Hospital
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- Arner, Peter (författare)
- Karolinska Institutet,Karolinska Institute
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- Uusitupa, Matti (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland,University of Eastern Finland
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- Ulven, Stine M. (författare)
- Univ Oslo, Inst Basic Med Sci, Dept Nutr, N-0316 Oslo, Norway,University of Oslo
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(creator_code:org_t)
- 2019-04-18
- 2019
- Engelska.
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Ingår i: Molecular Nutrition & Food Research. - : John Wiley & Sons. - 1613-4125 .- 1613-4133. ; 63:13
- Relaterad länk:
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https://www.duo.uio....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Scope To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with metabolic syndrome. Methods and results Subjects with metabolic syndrome undergo a 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants are included. PBMCs are obtained before and after intervention and total RNA is subjected to global transcriptome analysis. 1302 probe sets are differentially expressed between the diet groups (p-value < 0.05). Twenty-five of these are significantly regulated (FDR q-value < 0.25) and are mainly involved in mitochondrial function, cell growth, and cell adhesion. The list of 1302 regulated probe sets is subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response, and cell cycle are downregulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors, including NFR1, NFR2, and NF-kappa B, are downregulated in the healthy Nordic diet group. Conclusion These results suggest that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- gene-expression
- healthy Nordic diet
- metabolic syndrome
- peripheral blood mononuclear cells
- transcriptome
- gene-expression
- healthy Nordic diet
- metabolic syndrome
- peripheral blood mononuclear cells
- transcriptome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Myhrstad, Mari C ...
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de Mello, Vaness ...
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Dahlman, Ingrid
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Kolehmainen, Mar ...
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Paananen, Jussi
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Rundblad, Amanda
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visa fler...
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Carlberg, Carste ...
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Olstad, Ole Kris ...
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Pihlajamaki, Jus ...
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Holven, Kirsten ...
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Hermansen, Kjeld
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Dragsted, Lars O ...
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Gunnarsdottir, I ...
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Cloetens, Liesel ...
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Storm, Matilda U ...
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Åkesson, Björn
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Rosqvist, Fredri ...
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Hukkanen, Janne
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Herzig, Karl-Hei ...
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Risérus, Ulf, 19 ...
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Thorsdottir, Ing ...
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Poutanen, Kaisa ...
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Savolainen, Mark ...
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Schwab, Ursula
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Arner, Peter
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Uusitupa, Matti
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Ulven, Stine M.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Molecular Nutrit ...
- Av lärosätet
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Uppsala universitet
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Lunds universitet
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Karolinska Institutet