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Whole-Body MRI Surv...
Whole-Body MRI Surveillance : Baseline Findings in the Swedish Multicentre Hereditary TP53-Related Cancer Syndrome Study (SWEP53)
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- Omran, Meis (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ, Sweden
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- Tham, Emma (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ, Sweden
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- Brandberg, Yvonne (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden
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- Ahlström, Håkan, 1953- (author)
- Uppsala University,Uppsala universitet,Radiologi,Uppsala Univ, Sweden
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- Lundgren, Claudia, 1966- (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Uppsala University Hospital,Uppsala Univ Hosp, Sweden
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- Paulsson-Karlsson, Ylva (author)
- Department of Immunology, Genetics and Pathology, Uppsala University Hospital, Uppsala, Sweden,Uppsala Univ Hosp, Dept Immunol Genet & Pathol, SE-75185 Uppsala, Sweden.
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- Kuchinskaya, Ekaterina (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Klinisk genetik
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- Silander, Gustav (author)
- Umeå University,Umeå universitet,Onkologi,Umeå Univ, Dept Radiat Sci, SE-90187 Umeå, Sweden.
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- Rosén, Anna, 1975- (author)
- Umeå University,Umeå universitet,Onkologi,Umeå Univ, Dept Radiat Sci, SE-90187 Umeå, Sweden.
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- Persson, Fredrik (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Leonhardt, Henrik, 1963 (author)
- Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Radiol, SE-41345 Gothenburg, Sweden.
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- Stenmark-Askmalm, Marie (author)
- Division of Clinical Genetics, Department of Laboratory Medicine, Office for Medical Services, Skåne University Hospital, Lund, Sweden,Skane Univ Hosp, Off Med Serv, Dept Lab Med, Div Clin Genet, SE-22885 Lund, Sweden.
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- Berg, Johanna (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Lund Univ, Sweden; Ctr Med & Imaging & Funct, Sweden
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- van Westen, Danielle (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Ctr Med & Imaging & Funct, Sweden; Lund Univ, Sweden
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- Bajalica-Lagercrantz, Svetlana (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ, Sweden; Karolinska Univ, Sweden
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- Blomqvist, Lennart (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ, Sweden
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(creator_code:org_t)
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- 2022-01-13
- 2022
- English.
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In: Cancers. - : MDPI. - 2072-6694. ; 14:2
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Abstract
Subject headings
Close
- A surveillance strategy of the heritable TP53-related cancer syndrome (hTP53rc), commonly referred to as the Li–Fraumeni syndrome (LFS), is studied in a prospective observational nationwide multi-centre study in Sweden (SWEP53). The aim of this sub-study is to evaluate whole-body MRI (WB-MRI) regarding the rate of malignant, indeterminate, and benign imaging findings and the associated further workup generated by the baseline examination. Individuals with hTP53rc were enrolled in a surveillance program including annual whole-body MRI (WB-MRI), brain-MRI, and in female carriers, dedicated breast MRI. A total of 68 adults ≥18 years old have been enrolled to date. Of these, 61 fulfilled the inclusion criteria for the baseline MRI scan. In total, 42 showed a normal scan, while 19 (31%) needed further workup, of whom three individuals (3/19 = 16%) were diagnosed with asymptomatic malignant tumours (thyroid cancer, disseminated upper GI cancer, and liver metastasis from a previous breast cancer). Forty-three participants were women, of whom 21 had performed risk-reducing mastectomy prior to inclusion. The remaining were monitored with breast MRI, and no breast tumours were detected on baseline MRI. WB-MRI has the potential to identify asymptomatic tumours in individuals with hTP53rc syndrome. The challenge is to adequately and efficiently investigate all indeterminate findings. Thus, a multidisciplinary team should be considered in surveillance programs for individuals with hTP53rc syndrome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Cancer
- Cancer prevention
- Clinically actionable TP53 variant
- Germline TP53
- Hereditary breast cancer
- Hereditary cancer syndrome
- HTP53rc syndrome
- Li–Fraumeni
- MRI screening
- Surveillance program
- Whole-body MRI
- Cancer
- Cancer prevention
- Clinically actionable TP53 variant
- Germline TP53
- Hereditary breast cancer
- Hereditary cancer syndrome
- HTP53rc syndrome
- Li–Fraumeni
- MRI screening
- Surveillance program
- Whole-body MRI
- cancer
- cancer prevention
- clinically actionable TP53 variant
- germline TP53
- hTP53rc syndrome
- hereditary breast cancer
- hereditary cancer syndrome
- surveillance program
- whole-body MRI
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cancers
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- By the author/editor
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Omran, Meis
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Tham, Emma
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Brandberg, Yvonn ...
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Ahlström, Håkan, ...
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Lundgren, Claudi ...
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Paulsson-Karlsso ...
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Kuchinskaya, Eka ...
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Silander, Gustav
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Rosén, Anna, 197 ...
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Persson, Fredrik
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Leonhardt, Henri ...
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Stenmark-Askmalm ...
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Berg, Johanna
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van Westen, Dani ...
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Bajalica-Lagercr ...
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Blomqvist, Lenna ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Cancers
- By the university
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Umeå University
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Uppsala University
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Lund University
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Linköping University
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Karolinska Institutet
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University of Gothenburg