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- Mesa, D., et al.
(författare)
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Constraining masses and separations of unseen companions to five accelerating nearby stars star
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 665
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Tidskriftsartikel (refereegranskat)abstract
- Aims. In this work, we aim to constrain the masses and separations of potential substellar companions to five accelerating stars (HIP 1481, HIP 88399, HIP 96334, HIP 30314, and HIP 116063) using multiple data sets acquired with different techniques.Methods. Our targets were originally observed as part of the SPHERE/SHINE survey, and radial velocity (RV) archive data were also available for four of the five objects. No companions were originally detected in any of these data sets, but the presence of significant proper motion anomalies (PMas) for all the stars strongly suggested the presence of a companion. Combining the information from the PMas with the limits derived from the RV and SPHERE data, we were able to put constraints on the characteristics of the unseen companions.Results. Our analysis led to relatively strong constraints for both HIP 1481 and HIP 88399, narrowing down the companion masses to 2–5 MJup and 3–5 MJup and separations within 2–15 au and 3–9 au, respectively. Because of the large age uncertainties for HIP 96334, the poor observing conditions for the SPHERE epochs of HIP 30314, and the lack of RV data for HIP 116063, the results for these targets were not as well defined, but we were still able to constrain the properties of the putative companions within a reasonable confidence level.Conclusions. For all five targets, our analysis reveals that the companions responsible for the PMa signal would be well within reach for future instruments planned for the ELT (e.g., MICADO), which would easily achieve the required contrast and angular resolution. Our results therefore represent yet another confirmation of the power of multi-technique approaches for both the discovery and characterisation of planetary systems.
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| 2. |
- Leguit, R. J., et al.
(författare)
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EAHP 2020 workshop proceedings, pediatric myeloid neoplasms
- 2022
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Ingår i: Virchows Archiv. - : Springer Science and Business Media LLC. - 0945-6317 .- 1432-2307. ; 481:4, s. 621-646
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Forskningsöversikt (refereegranskat)abstract
- The first section of the bone marrow workshop of the European Association of Haematopathology 2020 Virtual Meeting was dedicated to pediatric myeloid neoplasms. The section covered the whole spectrum of myeloid neoplasms, including myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), myelodysplastic/myeloproliferative neoplasms (MDS/MPN), and acute myeloid leukemia. The workshop cases are hereby presented, preceded by an introduction on these overall rare diseases in this age group. Very rare entities such as primary myelofibrosis, pediatric MDS with fibrosis, and MDS/MPN with JMML-like features and t(4;17)(q12;q21); FIP1L1::RARA fusion, are described in more detail.
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| 3. |
- Squicciarini, V., et al.
(författare)
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A scaled-up planetary system around a supernova progenitor
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 664
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Tidskriftsartikel (refereegranskat)abstract
- Context. Virtually all known exoplanets reside around stars with M < 2.3 M⊙ either due to the rapid evaporation of the protostellar disks or to selection effects impeding detections around more massive stellar hosts.Aims. To clarify if this dearth of planets is real or a selection effect, we launched the planet-hunting B-star Exoplanet Abundance STudy (BEAST) survey targeting B stars (M > 2.4 M⊙) in the young (5-20 Myr) Scorpius-Centaurus association by means of the high-contrast spectro-imager SPHERE at the Very Large Telescope.Methods. In this paper we present the analysis of high-contrast images of the massive (M - 9 M⊙) star μ2 Sco obtained within BEAST. We carefully examined the properties of this star, combining data from Gaia and from the literature, and used state-of-the-art algorithms for the reduction and analysis of our observations.Results. Based on kinematic information, we found that μ2 Sco is a member of a small group which we label Eastern Lower Scorpius within the Scorpius-Centaurus association. We were thus able to constrain its distance, refining in turn the precision on stellar parameters. Around this star we identify a robustly detected substellar companion (14.4 ± 0.8 MJ)at a projected separation of 290 ± 10 au, and a probable second similar object (18.5 ± 1.5 MJ) at 21 ± 1 au. The planet-to-star mass ratios of these objects are similar to that of Jupiter to the Sun, and the flux they receive from the star is similar to those of Jupiter and Mercury, respectively.Conclusions. The robust and the probable companions of μ2 Sco are naturally added to the giant 10.9 MJ planet recently discovered by BEAST around the binary b Cen system. While these objects are slightly more massive than the deuterium burning limit, their properties are similar to those of giant planets around less massive stars and they are better reproduced by assuming that they formed under a planet-like, rather than a star-like scenario. Irrespective of the (needed) confirmation of the inner companion, μ2 Sco is the first star that would end its life as a supernova that hosts such a system. The tentative high frequency of BEAST discoveries is unexpected, and it shows that systems with giant planets or small-mass brown dwarfs can form around B stars. When putting this finding in the context of core accretion and gravitational instability formation scenarios, we conclude that the current modeling of both mechanisms is not able to produce this kind of companion. The completion of BEAST will pave the way for the first time to an extension of these models to intermediate and massive stars.
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| 5. |
- Weinberg, Olga K., et al.
(författare)
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The International Consensus Classification of acute myeloid leukemia
- 2023
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Ingår i: Virchows Archiv. - : Springer Science and Business Media LLC. - 0945-6317 .- 1432-2307. ; 482:1, s. 27-37
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Forskningsöversikt (refereegranskat)abstract
- Acute myeloid leukemias (AMLs) are overlapping hematological neoplasms associated with rapid onset, progressive, and frequently chemo-resistant disease. At diagnosis, classification and risk stratification are critical for treatment decisions. A group with expertise in the clinical, pathologic, and genetic aspects of these disorders developed the International Consensus Classification (ICC) of acute leukemias. One of the major changes includes elimination of AML with myelodysplasia-related changes group, while creating new categories of AML with myelodysplasia-related cytogenetic abnormalities, AML with myelodysplasia-related gene mutations, and AML with mutated TP53. Most of recurrent genetic abnormalities, including mutations in NPM1, that define specific subtypes of AML have a lower requirement of ≥ 10% blasts in the bone marrow or blood, and a new category of MDS/AML is created for other case types with 10–19% blasts. Prior therapy, antecedent myeloid neoplasms or underlying germline genetic disorders predisposing to the development of AML are now recommended as qualifiers to the initial diagnosis of AML. With these changes, classification of AML is updated to include evolving genetic, clinical, and morphologic findings.
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