| 1. |
- Attié, David, et al.
(författare)
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A time projection chamber with GEM-based readout
- 2017
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Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002. ; 856, s. 109-118
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Tidskriftsartikel (refereegranskat)abstract
- For the International Large Detector concept at the planned International Linear Collider, the use of time projection chambers (TPC) with micro-pattern gas detector readout as the main tracking detector is investigated. In this paper, results from a prototype TPC, placed in a 1. T solenoidal field and read out with three independent Gas Electron Multiplier (GEM) based readout modules, are reported. The TPC was exposed to a 6. GeV electron beam at the DESY II synchrotron. The efficiency for reconstructing hits, the measurement of the drift velocity, the space point resolution and the control of field inhomogeneities are presented.
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| 2. |
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| 3. |
- Engstrand, Åsa-Karin, 1971-, et al.
(författare)
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Från Ekholmen ut i Europa : Boken om Linköpings FC-dåtid, nutid, framtid
- 2015. - 1
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- "Allt började egentligen på gården där vi bodde i stadsdelen Ekholmen i Linköping." Så inleder Charlotte Rohlin sin unika och mycket personliga betraktelse över sin egen fotbollskarriär. Karriären har tagit henne från lilla Ekholmen ut i Europa, på en resa sammanflätad med klubben hon blivit trogen: Linköpings Fotboll Club. Det här är historien om LFC, klubben som etablerat sig som en av Sveriges främsta och mest framgångsrika damfotbollsklubbar med inte mindre än åtta nationella titlar på tio år. Läsaren får följa med på en fotbollsresa som sträcker sig från starten 2003 till 2014 och skildrar spelare, ledare och händelser som präglat klubben.Boken är skriven av fem supportrar till laget. Den inleds med en historisk tillbakablick och avslutas med ett välmatat statistikkapitel. Däremellan ryms allt det som hänt i klubben under de första tio, framgångsrika, åren. Boken har ett genomgående färgstarkt och rikt bildmaterial och bjuder på en och annan överraskning - även för inbitna LFC-supportrar. Så sätt dig bekvämt och följ med på resan. Från Ekholmen ut i Europa!
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| 4. |
- Hedberg, Vincent, et al.
(författare)
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Front-end electronics and readout system for the ILD TPC
- 2015
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- A high resolution TPC is the main option for a central tracking detector at the future International Linear Collider (ILC). It is planned that the MPGD (Micro Pattern Gas Detector) technology will be used for the readout. A Large Prototype TPC at DESY has been used to test the performance of MPGDs in an electron beam of energies up to 6 GeV. The first step in the technology development was to demonstrate that the MPGDs are able to achieve the necessary performance set by the goals of ILC. For this 'proof of principle' phase, the ALTRO front-end electronics from the ALICE TPC was used, modified to adapt to MPGD readout. The proof of principle has been verified and at present further improvement of the MPGD technology is going on, using the same readout electronics. The next step is the 'feasibility phase', which aims at producing front-end electronics comparable in size (few mm2) to the readout pads of the TPC. This development work is based on the succeeding SALTRO16 chip, which combines the analogue and digital signal processing in the same chip. This paper summarizes the status of this work and discusses how the experiences made so far can be exploited to improve the final readout electronics.
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| 5. |
- Lundqvist, Johan, et al.
(författare)
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Fungicide prochloraz induces oxidative stress and DNA damage in vitro
- 2016
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Ingår i: Food and Chemical Toxicology. - : Elsevier BV. - 0278-6915 .- 1873-6351. ; 91, s. 36-41
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Tidskriftsartikel (refereegranskat)abstract
- Prochloraz is widely used in horticulture and agriculture, e.g. as a post-harvest anti-mold treatment. Prochloraz is a known endocrine disruptor causing developmental toxicity with multiple mechanisms of action. However, data are scarce concerning other toxic effects. Since oxidative stress response, with formation of reactive oxygen species (ROS), is a common mechanism for different toxic endpoints, e.g. genotoxicity, carcinogenicity and teratogenicity, the aim of this study was to investigate if prochloraz can induce oxidative stress and/or DNA damage in human cells. A cell culture based in vitro model was used to study oxidative stress response by prochloraz, as measured by the activity of the nuclear factor erythroid 2-related factor 2 (Nrf2), a key molecule in oxidative defense mechanisms. It was observed that prochloraz induced oxidative stress in cultured human adrenocortical H295R and hepatoma HepG2 cells at non-toxic concentrations. Further, we used Comet assay to investigate the DNA damaging potential of prochloraz, and found that non-toxic concentrations of prochloraz induced DNA damage in HepG2 cells. These are novel findings, contradicting previous studies in the field of prochloraz and genotoxicity. This study reports a new mechanism by which prochloraz may exert toxicity. Our findings suggest that prochloraz might have genotoxic properties.
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| 6. |
- Minock, Michael, et al.
(författare)
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Natural Language Specification and Violation Reporting of Business Rules over ER-modeled Databases
- 2015
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Ingår i: Advances in Database Technology - EDBT 2015, 18<sup>th</sup> International Conference on Extending Database Technology, Brussels, Belgium, March 23-27, Proceedings. - : Open Proceedings.org. - 9783893180677 ; , s. 541-544
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Konferensbidrag (refereegranskat)abstract
- This paper presents our work on adapting and extending natural language interface (NLI) to database technology to support the specification and violation reporting of business rules. The resulting system allows non-technical users to author and manage a rulebook in controlled natural language – serving as a single point of definition that can be compiled into SQL to generate violation reports. To achieve this we represent business rules in tuple alculus, handle negation in our query re-writing algorithms and add support for natural language reflexives (e.g. ‘its’, ‘themselves’, etc.). Our results show a large class of business rules can be captured with these extensions. Although our approach is general, we present it applied to compliance checking of regulations over a materiel capability development information system at the Swedish Defence Materiel Administration. At EDBT we will also demonstrate this work over a more generic package delivery domain. While there has been recent effort in pursuing Semantics for Business Vocabulary and Business Rules (SBVR) in the semantic web and description logic communities, to our knowledge ours is the first attempt to provide this capability for ER-modeled relational databases.
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| 7. |
- Oskarsson, Björn, 1964-
(författare)
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Förbättrat lärande i utredningsmetodik
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med detta pedagogiska utvecklingsprojekt var att öka förståelsen för hur vi i undervisningen kan stötta studenternas lärande i utredningsmetodik.Efter att inledningsvis studerat litteratur om utredningsmetodik, interv-juades representanter för olika avdelningar på LiU, där studenterna arbe-tar med utredningsprojekt som ligger inom ramen för ovanstående be-skrivning. Intervjuer på 45-90 minuter genomfördes med representanter för sju avdelningar, från tre av LiUs institutioner. En specificering av res-pondenterna finns i bilaga 1. Intervjuerna spelades in med respondenter-nas samtycke.Utifrån intervjuerna valdes en kurs ut som case för djupare studier. Denna kurs följdes under projektets gång genom diskussioner med exami-nator och andra involverade lärare, samt genom enkäter riktade till kurs-deltagarna. Upplevda problem med kursen identifierades, förändringar genomfördes och följdes upp under två kursgenomföranden.
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| 8. |
- Oskarsson, Björn, 1964-
(författare)
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Total Cost Analysis in Logistics : Practical Execution, Learning, and Teaching in Higher Education
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Cost is considered a crucial factor in much decision-making in private and public organisations. Therefore, the ability to calculate total estimated costs for different alternatives is important. However, such total cost analysis is a challenging task. Providing students with the knowledge and skills needed for total cost analysis is therefore relevant in several disciplines within higher education.Within logistics management, total cost analysis is for decades by several scholars regarded as a ‘cornerstone’, a fundamental part of the discipline. However, except for describing the basic steps and presumptions, the literature does not give much support concerning how to conduct such analyses, or which the difficulties associated with total cost analysis are. This blank space in literature is not limited to the logistics discipline, it stretches throughout many disciplines. Neither does literature cover how to teach to support students’ learning of total cost analysis.Hence, to address the lack of research, the purpose of this thesis was formulated as follows: To contribute to the understanding of conducting, learning, and teaching total cost analysis.Three research questions were shaped to address each part of the purpose: conducting, learning and teaching.RQ1 What challenges are connected to the process of conducting total cost analysis?RQ2 What thresholds are there for learning how to conduct total cost analysis?RQ3 How can total cost learning be supported by suitable educational methods?The research questions are connected to each other in the sense that the challenges of conducting total cost analysis (RQ1) indicate within which areas total cost learning is difficult, and thereby where thresholds are to be investigated (RQ2). Further, knowledge about the learning thresholds is needed to discuss suitable educational activities (RQ3).The research was conducted by a combination of literature reviews and multiple case studies at four Higher Education Institutions, where both teachers and students were approached. The findings for RQ1 were developed in an abductive procedure walking back and forth between literature and cases. A twelve-step process for total cost analysis was defined, and specific challenges associated for each of these steps. Regarding learning thresholds (RQ2), perceived difficulties with learning total cost analysis were identified in the case studies. These difficulties were then analysed against threshold characteristics available in literature. This resulted in the identification of four total cost learning thresholds. Literature on constructivist-based teaching was used to suggest teaching methods to support learning (RQ3). These types of activities proved to match the ones most appreciated by teachers and students in the studied cases. The twelve-step process provides a more structured and holistic view of total cost analysis than previously available in the logistics literature. The description of challenges with conducting total cost analysis is novel, not only within logistics, but also generally, why this is a major contribution from this research. Aspects regarding teaching and learning connected to logistics, and to total cost analysis, are very sparsely addressed in literature, which makes the findings concerning learning thresholds and teaching methods valuable.The findings are believed to be useful for different stakeholders. First and foremost, teachers can use the findings for designing programs, courses, and course modules which cover the important aspects of total cost analysis with help from educational activities supporting the students’ learning. Second, for organisations where total cost analyses are conducted, the suggested process with its steps and associated challenges can be used to achieve better total cost analyses, and in turn more substantiated decisions. In the longer perspective, better education on total cost analysis at Higher Education Institutions will further strengthen the total cost competence in organisations, thereby improving the total cost-related decision making.Total cost analysis is not unique for the logistics discipline. Although focus in the study has been on Higher Education Institutions providing logistics courses, the findings are to a high extent believed to be relevant also for other disciplines dealing with total cost analysis.
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| 9. |
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| 10. |
- Rosenmai, Anna Kjerstine, et al.
(författare)
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In vitro bioanalysis of drinking water from source to tap
- 2018
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Ingår i: Water Research. - : Elsevier BV. - 0043-1354 .- 1879-2448. ; 139, s. 272-280
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Tidskriftsartikel (refereegranskat)abstract
- The presence of chemical pollutants in sources of drinking water is a key environmental problem threatening public health. Efficient removal of pollutants in drinking water treatment plants (DWTPs) is needed as well as methods for assessment of the total impact of all present chemicals on water quality. In the present study we have analyzed the bioactivity of water samples from source to tap, including effects of various water treatments in a DWTP, using a battery of cell-based bioassays, covering health-relevant endpoints. Reporter gene assays were used to analyze receptor activity of the aryl hydrocarbon receptor (AhR), estrogen receptor (ER), androgen receptor (AR), peroxisome proliferator-activated receptor alpha (PPAR alpha) and induction of oxidative stress by the nuclear factor erythroid 2-related factor 2 (Nrf2). DNA damage was determined by Comet assay. Grab water samples were concentrated by HLB or ENV solid phase extraction and the water samples assayed at a relative enrichment factor of 50. The enrichment procedure did not induce any bioactivity. No bioactivity was detected in Milli-Q water or drinking water control samples. Induction of AhR, ER and Nrf2 activities was revealed in source to tap water samples. No cytotoxicity, PPAR alpha or AR antagonist activity, or DNA damage were observed in any of the water samples. A low AR agonist activity was detected in a few samples of surface water, but not in the samples from the DWTP. The treatment steps at the DWTP, coagulation, granulated activated carbon filtration, UV disinfection and NH2CI dosing had little or no effect on the AhR, Nrf2 and ER bioactivity. However, nano filtration and passage through the distribution network drastically decreased AhR activity, while the effect on Nrf2 activity was more modest and no apparent effect was observed on ER activity. The present results suggest that bioassays are useful tools for evaluation of the efficiency of different treatment steps in DWTPs in reducing toxic activities. Bioassays of AhR and Nrf2 are useful for screening of effects of a broad range of chemicals in drinking water and ER activity can be monitored with a high sensitivity.
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