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Synthesis and Biolo...
Synthesis and Biological Evaluation of Novel Benzylidene Thiazolo Pyrimidin-3(5H)-One Derivatives
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- Akbas, Esvet (författare)
- Department of Chemistry, Van Yuzuncu Yil University, Van, Türkiye
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- Othman, Khdir A. (författare)
- Department of Chemistry, Van Yuzuncu Yil University, Van, Türkiye; Faculty of Science and Health, Department of Chemistry, Koya University, Koy Sanjaq, Iraq
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- Çelikezen, Fatih Çağlar (författare)
- Department of Chemistry, Bitlis Eren University Faculty of Science and Letter, Bitlis, Türkiye
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- Aydogan Ejder, Nebahat (författare)
- Department of Medical Microbiology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Türkiye
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- Turkez, Hasan (författare)
- Department of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum, Türkiye
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- Yapca, Omer Erkan (författare)
- Department of Obstetrics and Gynecology, Faculty of Medicine, Atatürk University, Erzurum, Türkiye
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- Mardinoglu, Adil (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Centre for Host-Microbiome Interactions Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London, United Kingdom
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(creator_code:org_t)
- Informa UK Limited, 2024
- 2024
- Engelska.
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Ingår i: Polycyclic aromatic compounds (Print). - : Informa UK Limited. - 1040-6638 .- 1563-5333. ; 44:5, s. 3061-3078
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Starting compound 1 was synthesized according to reference. 1 Benzylidene thiazole pyrimidin-3(5H)-ones were synthesized reactions of 1 with bromoacetic acid and various aryl-aldehydes in the same vessel via one-step, unlike studies in the literature. Quantum chemical parameters and full geometry optimizations for all compounds were computed using DFT based on B3LYP. Cytotoxic action potential of synthesized compounds was evaluated using trypan blue dye exclusion and MTT assays in different cell lines including adenocarcinoma alveolar basal epithelial-like adherent A549 cells, the colon adenocarcinoma HT-29 cells, prostate adenocarcinoma DU-145 cells, and diploid ARPE-19 retinal pigment epithelial cells. Embryotoxicity and genotoxicity assessments were performed on pluripotent human embryonal carcinoma NT2 and human lymphocyte cells, respectively. Compound A1 exhibited good anticancer activity on A549 and DU-145 cell lines, and the compounds including A3, 4, 6, and 9 induced cytotoxicity on A549 cells. The compounds A1-10 also showed a good biosafety profile at relatively lower concentrations.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- anticarcinogenic effect
- cytotoxicity
- genotoxicity
- MCR
- Pyrimidine
- theoretical chemistry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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