| 1. |
- Fusco, F.M., et al.
(författare)
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Isolation rooms for highly infectious diseases : an inventory of capabilities in European countries
- 2009
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Ingår i: Journal of Hospital Infection. - : Elsevier BV. - 0195-6701. ; 73:1, s. 15-23
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Tidskriftsartikel (refereegranskat)abstract
- Isolation of patients with highly infectious diseases (HIDs) in hospital rooms with adequate technical facilities is essential to reduce the risk of spreading disease. The European Network for Infectious Diseases (EUNID), a project co-funded by European Commission and involving 16 European Union member states, performed an inventory of high level isolation rooms (HIRs, hospital rooms with negative pressure and anteroom). In participating countries, HIRs are available in at least 211 hospitals, with at least 1789 hospital beds. The adequacy of this number is not known and will depend on prevailing circumstances. Sporadic HID cases can be managed in the available HIRs. HIRs could also have a role in the initial phases of an influenza pandemic. However, large outbreaks due to natural or to bioterrorist events will need management strategies involving healthcare facilities other than HIRs.
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| 2. |
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| 3. |
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| 4. |
- Abbondanno, U, et al.
(författare)
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The data acquisition system of the neutron time-of-flight facility n_TOF at CERN
- 2005
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 538:1-3, s. 692-702
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Tidskriftsartikel (refereegranskat)abstract
- The n_TOF facility at CERN has been designed for the measurement of neutron capture, fission and (n, xn) cross-sections with high accuracy. This requires a flexible and-due to the high instantaneous neutron flux-almost dead time free data acquisition system. A scalable and versatile data solution has been designed based on 8-bit flash-ADCs with sampling rates up to 2 GHz and 8 Mbyte memory buffer. The software is written in C and C++ and is running on PCs equipped with RedHat Linux.
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| 5. |
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| 6. |
- Brouqui, P., et al.
(författare)
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Infection control in the management of highly pathogenic infectious diseases : consensus of the European Network of Infectious Disease
- 2009
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Ingår i: The Lancet Infectious Diseases. - 1473-3099. ; 9:5, s. 301-311
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Forskningsöversikt (refereegranskat)abstract
- The European Network for Infectious Diseases (EUNID) is a network of clinicians, public health epidemiologists, microbiologists, infection control, and critical-care doctors from the European member states, who are experienced in the management of patients with highly infectious diseases. We aim to develop a consensus recommendation for infection control during clinical management and invasive procedures in such patients. After an extensive literature review, draft recommendations were amended jointly by 27 partners from 15 European countries. Recommendations include repetitive training of staff to ascertain infection control, systematic use of cough and respiratory etiquette at admission to the emergency department, fluid sampling in the isolation room, and analyses in biosafety level 3/4 laboratories, and preference for point-of-care bedside laboratory tests. Children should be cared for by paediatricians and intensive-care patients should be cared for by critical-care doctors in high-level isolation units (HLIU). Invasive procedures should be avoided if unnecessary or done in the HLIU, as should chest radiography, ultrasonography, and renal dialysis. Procedures that require transport of patients out of the HLIU should be done during designated sessions or hours in secure transport. Picture archiving and communication systems should be used. Post-mortem examination should be avoided; biopsy or blood collection is preferred.
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| 7. |
- Gadea, A, et al.
(författare)
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Hindered E4 decay of the 12(+) yrast trap in Fe-52
- 2005
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 619:1-2, s. 88-94
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Tidskriftsartikel (refereegranskat)abstract
- The gamma decay of the 12(+) yrast trap in Fe-52 has been measured for the first time. The two E4 gamma-branches to the 8(+) states are hindered with respect to other B(E4) reduced transition probabilities measured in the f(7/2) shell. The interpretation of the data is given in the full pf shell model framework, comparing the results obtained with different residual interactions. It is shown that measurements of hexadecapole transition probabilities constitute a powerful tool in discriminating the correct configuration of the involved wavefunctions.
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| 8. |
- Henkel, C., et al.
(författare)
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The density, the cosmic microwave background, and the proton-to-electron mass ratio in a cloud at redshift 0.9
- 2009
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 500:2, s. 725-734
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Tidskriftsartikel (refereegranskat)abstract
- Based on measurements with the Effelsberg 100-m telescope, a multi-line study of molecular species is presented toward the gravitational lens system PKS 1830-211, which is by far the best known target to study dense cool gas in absorption at intermediate redshift. Determining average radial velocities and performing Large Velocity Gradient radiative transfer calculations, the aims of this study are (1) to determine the density of the gas, (2) to constrain the temperature of the cosmic microwave background (CMB), and (3) to evaluate the proton-to-electron mass ratio at redshift z ˜ 0.89. Analyzing data from six rotational HC3N transitions (this includes the J=7≤ftarrow6 line, which is likely detected for the first time in the interstellar medium) we obtain n(H2) ~ 2600 cm-3 for the gas density of the south-western absorption component, assuming a background source covering factor, which is independent of frequency. With a possibly more realistic frequency dependence proportional to ν0.5 (the maximal exponent permitted by observational boundary conditions), n(H2) ~ 1700 cm-3. Again toward the south-western source, excitation temperatures of molecular species with optically thin lines and higher rotational constants are, on average, consistent with the expected temperature of the cosmic microwave background, T_CMB = 5.14 K. However, individually, there is a surprisingly large scatter which far surpasses expected uncertainties. A comparison of CS J =1 ≤ftarrow0 and 4≤ftarrow3 optical depths toward the weaker north-western absorption component results in T_ex = 11 K and a 1-σ error of 3 K. For the main component, a comparison of velocities determined from ten optically thin NH3 inversion lines with those from five optically thin rotational transitions of HC3N, observed at similar frequencies, constrains potential variations of the proton-to-electron mass ratio μ to Δμ / μ
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| 9. |
- Koch, Christian A, et al.
(författare)
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Does the expression of c-kit (CD117) in neuroendocrine tumors represent a target for therapy?
- 2006
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Ingår i: Annals of the New York Academy of Sciences. - : Wiley. - 0077-8923 .- 1749-6632. ; 1073, s. 517-26
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Tidskriftsartikel (refereegranskat)abstract
- Neuroendocrine tumors are very heterogeneous, develop from a variety of tissues, and can be difficult to diagnose. Without the clinical manifestation of metastases, it is often difficult to characterize them as malignant. Even so-called completely (R0) resected tumors can spread clinically visible metastases within a few months after initial surgery. Treatment options for neuroendocrine tumors including pheochromocytoma are limited. Molecular targeted therapies using tyrosine kinase inhibitors might prove to be helpful in patients with these tumors. In an immunohistochemical study, we examined KIT in 26 pheochromocytomas, 8 of which were malignant (3 adrenal pheochromocytomas, 5 paragangliomas). KIT expression was found in one of these 8 malignant tumors. This 2.5-cm-large adrenal pheochromocytoma originated from a woman with neurofibromatosis type 1 and spread into spine, skull, and lung. KIT expression could be demonstrated in 5% of tumor cells. On the basis of KIT expression immunohistochemically, we treated patients with neuroendocrine (i.e., medullary thyroid cancer) and other tumors with imatinib 400 mg per day, but without efficacy after 2 months of therapy. Similar results were shown by other investigators. Therefore, monotherapy with imatinib may not be efficacious in patients with neuroendocrine tumors that express KIT. Tyrosine kinase inhibitors such as sorafenib that targets several receptors in addition to KIT may be more efficacious in treating patients with neuroendocrine tumors.
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