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- Wilking, N., et al.
(författare)
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Long-term follow-up of the SBG 9401 study comparing tailored FEC-based therapy versus marrow-supported high-dose therapy
- 2007
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Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 18:4, s. 694-700
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Tidskriftsartikel (refereegranskat)abstract
- Background: The purpose was to investigate adjuvant marrow-supportive high-dose chemotherapy compared with an equitoxicity-tailored comparator arm. Patients and methods: Five hundred and twenty-five women below theage of 60 years with operated high-risk primary breast cancer were randomised to nine cycles of granulocyte colony-stimulating factor supported and individually tailored FEC (5-fluorouracil, epirubicin, cyclophosphamide), (n = 251) or standard FEC followed by marrow-supported high-dose therapy with CTCb (cyclophosphamide, thiotepa, carboplatin) therapy (n = 274), followed by locoregional radiotherapy and tamoxifen for 5 years. Results: There were 104 breast cancer relapses in the tailored FEC group versus 139 in the CTCb group (double triangular method by Whitehead, P = 0.046), with a median follow-up of all included patients of 60.8 months. The event-free survival demonstrated 121 and 150 events in the tailored FEC- and CTCb group, respectively [P = 0.074, hazard ratio (HR) 0.804, 95% confidence interval (CI) 0.633-1.022]. Ten patients in the tailored FEC regimen developed acute myeloid leukaemia (AML)/myelodysplasia (MDS). One hundred deaths occurred in the tailored FEC group and 121 in the CTCb group (P = 0.287, HR 0.866, 95% CI 0.665-1.129). Conclusion: The update of this study shows an improved outcome linked to the tailored FEC treatment in relation to breast cancer relapse, but also an increased incidence of AML/MDS. © 2007 Oxford University Press.
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| 3. |
- Josephson Hesse, Kristina, 1958-
(författare)
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Contacts and Trade at Late Bronze Age Hazor : Aspects of Intercultural Relationships and Identity in the Eastern Mediterranean
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Hazor’s role in an international Late Bronze Age context has long been indicated but never thoroughly investigated. This role, I believe, was more crucial than previously stressed. My assumption is based on the very large size of this flourishing city which, according to documents, possessed ancient traditions of diplomatic connections and trade with Mesopotamia in the Middle Bronze Age. Its strategic position along the most important N-S and E-W main trade routes, which connected Egypt with Syria-Mesopotamia and the Mediterranean Sea with the city and beyond, promoted contacts. Hazor was a city-state in Canaan, a province under Egyptian domination and exploitation during this period, a position that also influenced the city’s international relations. Methodologically the thesis examines areas of the earlier and the renewed excavations at Hazor, with the aim of discussing the city’s interregional relations and cultural belonging based on external influences in architectural structures (mainly temples), imported pottery and artistic expressions in small finds, supported by written evidence. Cultic influences are also considered. Various origin and find contexts of the imported and culturally influenced material can be recognized, which imply three concepts in the field of interaction studies found within the framework of a modified World Systems Theory and also according to C. Renfrew’s Peer Polity Interaction model: 1) The northern influenced material at Hazor should be understood in the context of cultural identity. It continues from earlier periods and is maintained through external trade and the regional interaction between Canaanite city-states in the north, resulting in certain cultural homogeneity. 2) A core-periphery approach is used to explain the special unequal relation between Canaan and Egypt, in which Hazor might have possessed an integrating semi-peripheral role, a kind of diplomatic position between Egypt and its northern enemies. The city’s loyalty to Egypt is hinted at in documents and in the increasing evidences of emulation in elite contexts appearing on the site. 3) A model of ‘interregional interaction networks’ describes the organization of the trade which provided certain consumers at Hazor with the Aegean and Cypriote pottery and its desirable content. The cargo of the Ulu Burun and Cape Gelidonya ships and documents show that luxury items were transited from afar through Canaan. Such long-distance trade / exchange require professional traders that established networks along the main trade routes. The thesis suggests that Hazor possessed a node position in such a network.
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| 4. |
- Löfgren, Linus, et al.
(författare)
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Low-power humidity sensor for RFID applications
- 2008
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Ingår i: 4M2008 Conference, Cardiff, UK.
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Konferensbidrag (refereegranskat)abstract
- Wireless sensors incorporated in RFID systems are important in several industrial, consumer and logisticsapplications. By extending RFID tags to sensing applications, the products become smarter. Application areas forthese smart tags include; health care (verification of the environmental conditions during transport or in storage of e.g.diapers, bandages, etc.), food monitoring (food quality during transport, storage and sales) and construction industry(e.g. building material).In this paper, a small, very low power and low cost humidity sensor tailor made for passive RFID applications ispresented. The sensor consists of a glass chip substrate with a sub-micron interdigitated gold electrode structurecovered with a humidity sensitive polyimide layer. The humidity absorbed by the sensing layer is measuredcapacitively. Finite element modeling and analytic calculations were used to determine the design of the interdigitatedelectrodes and the optimal thickness of the polyimide layer. A read-out electronics circuit was designed and used toevaluate the sensor. Sensors were fabricated and calibrations have been made to verify their function. The sensorresponse was close to linear from below 20 to above 90 %RH and its response time was proven to be at least as shortas that of the climate chamber, namely 0.1 %RH/s. The concept can easily be adapted to measure a range of otherparameters such as temperature or the presence of certain substances.
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