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Cidofovir for BK Vi...
Cidofovir for BK Virus-Associated Hemorrhagic Cystitis: A Retrospective Study
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Cesaro, Simone (author)
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Hirsch, Hans H. (author)
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Faraci, Maura (author)
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Owoc-Lempach, Joanna (author)
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Beltrame, Angela (author)
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Tendas, Andrea (author)
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Baltadakis, Ioannis (author)
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Dalle, Jean-Hughes (author)
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Koc, Yener (author)
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- Toporski, Jacek (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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Styczynski, Jan (author)
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Yesilipek, M. Akif (author)
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Heinz, Werner (author)
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Caniglia, Maurizio (author)
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Rascon, Jelena (author)
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Fauser, Axel A. (author)
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Michallet, Mauricette (author)
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Lopez-Corral, Lucia (author)
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Neuburger, Stefan (author)
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Tridello, Gloria (author)
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Einsele, Herman (author)
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(creator_code:org_t)
- Oxford University Press (OUP), 2009
- 2009
- English.
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In: Clinical Infectious Diseases. - : Oxford University Press (OUP). - 1537-6591 .- 1058-4838. ; 49:2, s. 233-240
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Background. BK virus-associated hemorrhagic cystitis (BKV-HC) is a severe complication after allogeneic hematopoietic stem cell transplantation (HSCT), but antiviral treatment for this condition has not been evaluated. Methods. We conducted a retrospective survey on the safety and outcome of cidofovir treatment for patients with BKV-HC in centers affiliated with the European Group for Blood and Marrow Transplantation. Results. From 1 April 2004 to 31 December 2007, 62 patients received a diagnosis of BKV-HC after a median interval of 35 days after HSCT (range, 3-577 days). Fifty-seven patients (92%) received intravenous cidofovir, whereas 5 patients received cidofovir intravesically. Complete response (CR) was recorded in 38 (67%) of 57 patients with HC treated with intravenous cidofovir, whereas partial response (PR) was documented in 7 patients (12%). CR was documented in 3 patients and PR in 1 patient with HC treated with intravesical cidofovir. A reduction of 1-3 logs in BKV load was documented in 8 of the 10 patients achieving CR. Mild-to-moderate toxic effects were recorded in 18 of 57 patients who received intravenous cidofovir administration. In a multivariate analysis, the factors significantly associated with response to cidofovir were the stem cell source (Pp. 01) and the use of total body irradiation (P = .03). After a median follow-up of 287 days, overall survival and total treatment-related mortality rates were 63% and 40% for patients achieving CR, compared with 14% and 72% for patients with PR or no response to cidofovir, respectively (P < .001 and P = .001, respectively). Conclusions. Cidofovir may be a potentially effective therapy for BKV-HC, but evidence supporting its use requires randomized controlled trials.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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- ref (subject category)
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- By the author/editor
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Cesaro, Simone
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Hirsch, Hans H.
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Faraci, Maura
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Owoc-Lempach, Jo ...
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Beltrame, Angela
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Tendas, Andrea
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show more...
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Baltadakis, Ioan ...
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Dalle, Jean-Hugh ...
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Koc, Yener
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Toporski, Jacek
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Styczynski, Jan
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Yesilipek, M. Ak ...
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Heinz, Werner
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Caniglia, Mauriz ...
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Rascon, Jelena
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Fauser, Axel A.
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Michallet, Mauri ...
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Lopez-Corral, Lu ...
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Neuburger, Stefa ...
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Tridello, Gloria
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Einsele, Herman
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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Clinical Infecti ...
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Lund University