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Design and rational...
Design and rationale of the Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Standard DAPT Regimen (MASTER DAPT) Study
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- Frigoli, Enrico (författare)
- Univ Bern, Clin Trials Unit, Bern, Switzerland
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- Smits, Pieter (författare)
- Maasstad Hosp, Dept Cardiol, Rotterdam, Netherlands
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- Vranckx, Pascal (författare)
- Jessa Ziekenhuis, Hartcentrum Hasselt, Dept Cardiol & Crit Care Med, Hasselt, Belgium;Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium
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- Ozaki, Yokio (författare)
- Fujita Hlth Univ, Sch Med, Dept Cardiol, Toyoake, Aichi, Japan
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- Tijssen, Jan (författare)
- Univ Amsterdam, Acad Med Ctr, AMC Heartctr, Amsterdam, Netherlands
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- Juni, Peter (författare)
- Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Appl Hlth Res Ctr, Toronto, ON, Canada
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- Morice, Marie-Claude (författare)
- CERC, Massy, France
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- Onuma, Yoshinobu (författare)
- Erasmus MC, Thorax Ctr, Rotterdam, Netherlands
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- Windecker, Stephan (författare)
- Bern Univ Hosp, Dept Cardiol, Bern, Switzerland
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- Frenk, Andre (författare)
- Bern Univ Hosp, Dept Cardiol, Bern, Switzerland
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- Spaulding, Christian (författare)
- Paris Descartes Univ, Hop Europeen Georges Pompidou, AP HP, INSERM,U 970,Sudden Death Expert Ctr,Cardiol Dept, Paris, France
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- Chevalier, Bernard (författare)
- Ramsay Gen Sante, Intervent Cardiol Dept, Inst Cardiovasc Paris Sud, Massy, France
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- Barbato, Emanuele (författare)
- Cardiovasc Res Ctr Aalst, Aalst, Belgium;Univ Federico II Naples, Dept Adv Biomed Sci, Div Cardiol, Naples, Italy
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- Tonino, Pim (författare)
- Catharina Hosp, Dept Cardiol, Eindhoven, Netherlands
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- Hildick-Smith, David (författare)
- Brighton & Sussex Univ Hosp NHSTrust, Brighton, E Sussex, England
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- Roffi, Marco (författare)
- Geneva Univ Hosp, Div Cardiol, Geneva, Switzerland
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- Kornowski, Ran (författare)
- Tel Aviv Univ, Sackler Sch Med, Rabin Med Ctr, Tel Aviv, Israel
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- Schultz, Carl (författare)
- Univ Western Australia, Royal Perth Hosp Campus, Dept Cardiol, Perth, WA, Australia
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- Lesiak, Maciej (författare)
- Univ Med Sci, Dept Cardiol 1, Poznan, Poland
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- Iniguez, Andres (författare)
- Hosp Alvaro Cunqueiro, Vigo, Spain
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- Colombo, Antonio (författare)
- IRCCS San Raffaele Sci Inst, Unit Cardiovasc Intervent, Milan, Italy
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- Alasnag, Mirvat (författare)
- King Fahad Armed Forces Hosp, Dept Cardiol, Jeddah, Saudi Arabia
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- Mullasari, Ajit (författare)
- Madras Med Mission, Chennai, Tamil Nadu, India
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- James, Stefan K, 1964- (författare)
- Uppsala universitet,Kardiologi
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- Stankovic, Goran (författare)
- Univ Belgrade, Clin Ctr Serbia, Dept Cardiol, Belgrade, Serbia;Univ Belgrade, Fac Med, Belgrade, Serbia
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- Ong, Paul J. L. (författare)
- Tan Tock Seng Hosp, Singapore, Singapore
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- Rodriguez, Alfredo E. (författare)
- Otamendi Hosp, Buenos Aires Sch Med, Cardiac Unit, Cardiovasc Res Ctr CECI, Buenos Aires, DF, Argentina
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- Mahfoud, Felix (författare)
- Saarland Univ Hosp, Homburg, Germany
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- Bartunek, Jozef (författare)
- Bern Univ Hosp, Dept Cardiol, Bern, Switzerland
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- Moschovitis, Aris (författare)
- Bern Univ Hosp, Dept Cardiol, Bern, Switzerland
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- Laanmets, Peep (författare)
- North Estonia Med Ctr Fdn, Tallinn, Estonia
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- Leonardi, Sergio (författare)
- Fdn IRCCS Policlin San Matteo, Pavia, Italy
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- Heg, Dik (författare)
- Univ Bern, Clin Trials Unit, Bern, Switzerland
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- Sunnaker, Mikael (författare)
- Univ Bern, Clin Trials Unit, Bern, Switzerland
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- Valgimigli, Marco (författare)
- Bern Univ Hosp, Dept Cardiol, Bern, Switzerland
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(creator_code:org_t)
- MOSBY-ELSEVIER, 2019
- 2019
- Engelska.
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Ingår i: American Heart Journal. - : MOSBY-ELSEVIER. - 0002-8703 .- 1097-6744. ; 209, s. 97-105
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background The optimal duration of antiplatelet therapy in high-bleeding risk (HBR) patients with coronary artery disease treated with newer-generation drug-eluting bioresorbable polymer-coated stents remains unclear. Design MASTER DAPT (clinicaltrial.gov NCT03023020) is an investigator-initiated, open-label, multicenter, randomized controlled trial comparing an abbreviated versus a standard duration of antiplatelet therapy after bioresorbable polymer-coated Ultimaster (TANSEI) sirolimus-eluting stent implantation in approximately 4,300 HBR patients recruited from >= 100 interventional cardiology centers globally. After a mandatory 30-day dual-antiplatelet therapy (DAPT) run-in phase, patients are randomized to (a) a single antiplatelet regimen until study completion or up to 5 months in patients with clinically indicated oral anticoagulation (experimental 1-month DAPT group) or (b) continue DAPT for at least 5 months in patients without or 2 in patients with concomitant indication to oral anticoagulation, followed by a single antiplatelet regimen (standard antipkitelet regimen). With a final sample size of 4,300 patients, this study is powered to assess the noninferiority of the abbreviated antiplatelet regimen with respect to the net adverse clinical and major adverse cardiac and cerebral events composite end points and if satisfied for the superiority of abbreviated as compared to standard antiplatelet therapy duration in terms of major or clinically relevant nonmajor bleeding. Study end points will be adjudicated by a blinded Clinical Events Committee. Conclusions The MASTER DAPT study is the first randomized controlled trial aiming at ascertaining the optimal duration of antiplatelet therapy in HBR patients treated with sirolimus-eluting bioresorbable polymer-coated stent implantation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Frigoli, Enrico
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Smits, Pieter
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Vranckx, Pascal
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Ozaki, Yokio
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Tijssen, Jan
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Juni, Peter
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Morice, Marie-Cl ...
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Onuma, Yoshinobu
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Windecker, Steph ...
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Frenk, Andre
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Spaulding, Chris ...
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Chevalier, Berna ...
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Barbato, Emanuel ...
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Tonino, Pim
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Hildick-Smith, D ...
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Roffi, Marco
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Kornowski, Ran
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Schultz, Carl
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Lesiak, Maciej
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Iniguez, Andres
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Colombo, Antonio
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Alasnag, Mirvat
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Mullasari, Ajit
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James, Stefan K, ...
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Stankovic, Goran
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Ong, Paul J. L.
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Rodriguez, Alfre ...
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Mahfoud, Felix
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Bartunek, Jozef
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Moschovitis, Ari ...
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Laanmets, Peep
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Leonardi, Sergio
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Heg, Dik
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Sunnaker, Mikael
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Valgimigli, Marc ...
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American Heart J ...
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