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High-Dose Chemother...
High-Dose Chemotherapy Compared With Standard Chemotherapy and Lung Radiation in Ewing Sarcoma With Pulmonary Metastases : Results of the European Ewing Tumour Working Initiative of National Groups, 99 Trial and EWING 2008
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- Dirksen, Uta (författare)
- University Hospital Essen
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- Brennan, Bernadette (författare)
- Royal Manchester Children's Hospital
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- Le Deley, Marie Cécile (författare)
- University of Paris-Saclay,Centre Oscar Lambret
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- Cozic, Nathalie (författare)
- Institut Gustave Roussy
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- van den Berg, Henk (författare)
- Emma Children’s Hospital,Academic Medical Center of University of Amsterdam (AMC)
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- Bhadri, Vivek (författare)
- Cancer Institute of New South Wales
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- Brichard, Bénédicte (författare)
- Saint-Luc University Hospital
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- Claude, Line (författare)
- Centre Léon Bérard
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- Craft, Alan (författare)
- University of Newcastle upon Tyne
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- Amler, Susanne (författare)
- University of Münster,Friedrich Loeffler Institute
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- Gaspar, Natalie (författare)
- Institut Gustave Roussy
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- Gelderblom, Hans (författare)
- Leiden University Medical Centre
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- Goldsby, Robert (författare)
- UCSF Benioff Children‘s Hospital,University of California, San Francisco
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- Gorlick, Richard (författare)
- University of Texas
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- Grier, Holcombe E. (författare)
- Boston Children's Hospital
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- Guinbretiere, Jean Marc (författare)
- Hôpital René-Huguenin
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- Hauser, Peter (författare)
- Semmelweis University
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- Hjorth, Lars (författare)
- Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups
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- Janeway, Katherine (författare)
- Boston Children's Hospital
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- Juergens, Heribert (författare)
- University Hospital Münster
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- Judson, Ian (författare)
- Royal Marsden NHS Foundation Trust
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- Krailo, Mark (författare)
- University of Southern California
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- Kruseova, Jarmila (författare)
- Charles University in Prague
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- Kuehne, Thomas (författare)
- University Children's Hospital, Basel
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- Ladenstein, Ruth (författare)
- Medical University of Vienna
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- Lervat, Cyril (författare)
- Centre Oscar Lambret
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- Lessnick, Stephen L. (författare)
- Ohio State University
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- Lewis, Ian (författare)
- University of Leeds
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- Linassier, Claude (författare)
- University Hospital of Tours
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- Marec-Berard, Perrine (författare)
- Pediatric Hematology and Oncology Institute (IHOPE)
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- Marina, Neyssa (författare)
- Five Prime Therapeutics Inc
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- Morland, Bruce (författare)
- Birmingham Children's Hospital
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- Pacquement, Hélène (författare)
- Curie Institute, Paris
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- Paulussen, Michael (författare)
- Witten/Herdecke University
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- Randall, R. Lor (författare)
- University of California, Davis
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- Ranft, Andreas (författare)
- University of Paris-Saclay,Institut Gustave Roussy
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- Le Teuff, Gwénaël (författare)
- University of Birmingham
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- Wheatley, Keith (författare)
- University College London Hospital
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- Whelan, Jeremy (författare)
- University of Pennsylvania,The Children's Hospital of Philadelphia
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- Womer, Richard (författare)
- Seattle Children’s Hospital
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- Oberlin, Odile (författare)
- Institut Gustave Roussy
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- Hawkins, Douglas S. (författare)
- Children's Hospital and Regional Medical Center, Seattle,Seattle Children’s Hospital
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(creator_code:org_t)
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Euro-EW.I.N.G. 99 Investigators
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- 2019
- 2019
- Engelska 11 s.
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Ingår i: Journal of Clinical Oncology. - 0732-183X. ; 37:34, s. 3192-3202
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- PURPOSE: The R2Pulm trial was conducted to evaluate the effect of busulfan-melphalan high-dose chemotherapy with autologous stem-cell rescue (BuMel) without whole-lung irradiation (WLI) on event-free survival (main end point) and overall survival, compared with standard chemotherapy with WLI in Ewing sarcoma (ES) presenting with pulmonary and/or pleural metastases. METHODS: From 2000 to 2015, we enrolled patients younger than 50 years of age with newly diagnosed ES and with only pulmonary or pleural metastases. Patients received chemotherapy with six courses of vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) and one course of vincristine, dactinomycin, and ifosfamide (VAI) before either BuMel or seven courses of VAI and WLI (VAI plus WLI) by randomized assignment. The analysis was conducted as intention to treat. The estimates of the hazard ratio (HR), 95% CI, and P value were corrected for the three previous interim analyses by the inverse normal method. RESULTS: Of 543 potentially eligible patients, 287 were randomly assigned to VAI plus WLI (n = 143) or BuMel (n = 144). Selected patients requiring radiotherapy to an axial primary site were excluded from randomization to avoid excess organ toxicity from interaction between radiotherapy and busulfan. Median follow-up was 8.1 years. We did not observe any significant difference in survival outcomes between treatment groups. Event-free survival was 50.6% versus 56.6% at 3 years and 43.1% versus 52.9% at 8 years, for VAI plus WLI and BuMel patients, respectively, resulting in an HR of 0.79 (95% CI, 0.56 to 1.10; P = .16). For overall survival, the HR was 1.00 (95% CI, 0.70 to 1.44; P = .99). Four patients died as a result of BuMel-related toxicity, and none died after VAI plus WLI. Significantly more patients in the BuMel arm experienced severe acute toxicities than in the VAI plus WLI arm. CONCLUSION: In ES with pulmonary or pleural metastases, there is no clear benefit from BuMel compared with conventional VAI plus WLI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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- Av författaren/redakt...
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Dirksen, Uta
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Brennan, Bernade ...
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Le Deley, Marie ...
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Cozic, Nathalie
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van den Berg, He ...
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Bhadri, Vivek
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Brichard, Bénédi ...
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Claude, Line
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Craft, Alan
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Amler, Susanne
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Gaspar, Natalie
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Gelderblom, Hans
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Goldsby, Robert
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Gorlick, Richard
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Grier, Holcombe ...
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Guinbretiere, Je ...
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Hauser, Peter
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Hjorth, Lars
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Janeway, Katheri ...
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Juergens, Heribe ...
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Judson, Ian
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Krailo, Mark
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Kruseova, Jarmil ...
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Kuehne, Thomas
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Ladenstein, Ruth
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Lervat, Cyril
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Lessnick, Stephe ...
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Lewis, Ian
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Linassier, Claud ...
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Marec-Berard, Pe ...
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Marina, Neyssa
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Morland, Bruce
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Pacquement, Hélè ...
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Paulussen, Micha ...
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Randall, R. Lor
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Ranft, Andreas
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Le Teuff, Gwénaë ...
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Wheatley, Keith
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Whelan, Jeremy
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Womer, Richard
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Oberlin, Odile
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Hawkins, Douglas ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Pediatrik
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