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- Aad, G., et al.
(författare)
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- 2012
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swepub:Mat__t (refereegranskat)
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| 2. |
- Rajalahti, Tarja, et al.
(författare)
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Proteins in different Synechocystis compartments have distinguishing N-terminal features : a combined proteomics and multivariate sequence analysis
- 2007
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 6:7, s. 2420-2434
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Tidskriftsartikel (refereegranskat)abstract
- Cyanobacteria have a cell envelope consisting of a plasma membrane, a periplasmic space with a peptidoglycan layer, and an outer membrane. A third, separate membrane system, the intracellular thylakoid membranes, is the site for both photosynthesis and respiration. All membranes and luminal spaces have unique protein compositions, which impose an intriguing mechanism for protein sorting of extracytoplasmic proteins due to single sets of translocation protein genes. It is shown here by multivariate sequence analyses of many experimentally identified proteins in Synechocystis, that proteins routed for the different extracytosolic compartments have correspondingly different physicochemical properties in their signal peptide and mature N-terminal segments. The full-length mature sequences contain less significant information. From these multivariate, N-terminal property-profile models for proteins with single experimental localization, proteins with ambiguous localization could, to a large extent, be predicted to a defined compartment. The sequence properties involve amino acids varying especially in volume and polarizability and at certain positions in the sequence segments, in a manner typical for the various compartment classes. Potential means of the cell to recognize the property features are discussed, involving the translocation channels and two Type I signal peptidases with different cellular localization, and charge features at their membrane interfaces.
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| 3. |
- Lindeblad, G., et al.
(författare)
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Cognitive and adaptive functioning in congenital and childhood forms of myotonic dystrophy type 1: a longitudinal study
- 2019
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Ingår i: Developmental Medicine and Child Neurology. - : Wiley. - 0012-1622 .- 1469-8749. ; 61:10, s. 1214-1220
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To conduct a longitudinal follow-up of the development of global cognitive abilities and adaptive skills in individuals with congenital and childhood forms of myotonic dystrophy type 1 (DM1). Method: Fifty-one participants (29 males, 22 females, mean age 19y 5mo, SD 4y 11mo, range 10y 10mo–28y 11mo) were divided into severe congenital (n=16), mild congenital (n=17), and childhood DM1 (n=18) subgroups. The average time between the first and second assessments was 7years 8months. Adaptive skills were evaluated using the Vineland Adaptive Behavior Scales and global cognitive functioning using Wechsler scales. Results: There was no statistically significant decline in cognitive abilities and adaptive behaviour. A tendency of decline regarding the level of intellectual disability was found in the congenital DM1 groups but not in the childhood group. In the congenital DM1 groups, the gap in relation to typically developing peers in cognitive and adaptive functioning increased. Predictors of change over time in adaptive skills were age and current level of intellectual disability: individuals with severe intellectual disability and younger individuals deteriorated the most. However, when raw scores were compared, no actual regression in adaptive functioning was found. Interpretation: The participants had not lost any important adaptive skills. Greater cognitive and adaptive development was found in the childhood group than in the congenital groups. What this paper adds: There is no absolute decline in cognitive and adaptive abilities in individuals with congenital and childhood myotonic dystrophy type 1. Pace of development is slow in comparison with normative data. The childhood group tended to show greater cognitive and adaptive development than the congenital groups. © 2019 Mac Keith Press
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| 7. |
- Ribé, Veronica, et al.
(författare)
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Ecotoxicological assessment and evaluation of a pine bark biosorbent treatment of five landfillleachates
- 2012
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Ingår i: Waste Management. - : Elsevier BV. - 0956-053X .- 1879-2456. ; 32:10, s. 1886-1894
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Tidskriftsartikel (refereegranskat)abstract
- When selecting a landfill leachate treatment method the contaminant composition of theleachate should be considered in order to obtain the most cost-effective treatment option. In this studythe filter material pine bark was evaluated as a treatment for five landfill leachates originating fromdifferent cells of the same landfill in Sweden. The objective of the study was to determine the uptake,or release, of metals and dissolved organic carbon (DOC) during a leaching test using the pine barkfilter material with the five different landfill leachates. Furthermore the change of toxicity aftertreatment was studied using a battery of aquatic bioassays assessing luminescent bacteria (Vibriofischeri) acute toxicity (30-min Microtox®), immobility of the crustacean Daphnia magna, growthinhibition of the algae Pseudokirchneriella subcapitata and the aquatic plant Lemna minor; andgenotoxicity with the bacterial Umu-C assay. The results from the toxicity tests and the chemicalanalysis were analyzed in a Principal Component Analysis and the toxicity of the samples before andafter treatment was evaluated in a toxicity classification. The pine bark filter material reduced theconcentrations of metal contaminants from the landfill leachates in the study, with some exceptions forCu and Cd. The Zn uptake of the filter was high for heavily contaminated leachates (≥73%), althoughsome desorption of zinc occurred in less contaminated waters. Some of the leachates may requirefurther treatment due to discharge into a natural recipient in order to reduce the risk of possiblebiological effects. The difference in pH changes between the different leachates was probably due tovariations in buffering capacity, affected by physicochemical properties of the leachate. The greatestdesorption of phenol during filtration occurred in leachates with high conductivity or elevated levels ofmetals or salts. Generally, the toxicity classification of the leachates implies that although filtertreatment with pine bark removes metal contaminants from the leachates effectively, it does not alterleachate toxicity noticeably. The leachates with the highest conductivity, pH and metal concentrationsare most strongly correlated with an increased toxic response in the score plots of both untreated andtreated leachates. This is in line with the toxicity classification of the leachate samples. The results fromthis study highlight the importance of evaluating treatment efficiency from the perspective of potentialrecipient effects, rather than in terms of residual concentrations of individual contaminants whentreating waters with a complex contamination matrix, such as landfill leachates.
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| 9. |
- Van Der Wee, Marlies, et al.
(författare)
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Techno-economic evaluation of FTTH migration for a network provider : Comparison of NG-AON and TWDM-PON
- 2013
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Ingår i: Asia Communications and Photonics Conference, ACP. - Washington, D.C. : OSA - The Optical Society. - 9781557529893
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Konferensbidrag (refereegranskat)abstract
- This paper studies the business case of migration from legacy FTTH networks like active star Ethernet and GPON towards NG-AON and TWDM-PON for a network provider, evaluating its techno-economic viability and suggesting possible improvements.
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