SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Pagano P.)
 

Sökning: WFRF:(Pagano P.) > (2003-2004) > Fanconi anaemia pro...

Fanconi anaemia proteins : Major roles in cell protection against oxidative damage

Pagano, G. (författare)
Italian National Cancer Institute, G. Pascale Foundation, Paediatric Oncology Research Centre, Mercogliano (AV), Italy, Istituto Nazionale Tumori, Fondazione G. Pascale, v. M. Semmola, I-80131 Naples, Italy
Youssoufian, H. (författare)
Clinical Discovery, Bristol-Myers Squibb Company, Princeton, NJ, United States
Anak, S.S. (författare)
Dept. of Paediat. Haematol./Oncolog., Istanbul Univ. School of Medicine, Istanbul, Turkey
visa fler...
Brunk, Ulf (författare)
Linköpings universitet,Hälsouniversitetet,Farmakologi
Calzone, R. (författare)
Department of Genetics, Elena d'Aosta Hospital, Naples, Italy
Clarke, A.A. (författare)
Department of Haematology, St. George's Hosp. Medical School, University of London, London, United Kingdom
Degan, P. (författare)
Italian National Cancer Institute, Genoa, Italy
D'Ischia, M. (författare)
Department of Organic Chemistry, Federico II Naples University, Naples, Italy, Department of Physiology, Valencia University, Valencia, Spain
Dunster, C. (författare)
Division of Life Sciences, King's College, London, United Kingdom
Giudice, A. (författare)
Italian National Cancer Institute, Genoa, Italy
Iaccarino, M. (författare)
Italian National Cancer Institute, Genoa, Italy
Hirsch-Kauffmann, M. (författare)
Kelly, F.J. (författare)
Division of Life Sciences, King's College, London, United Kingdom
Lloret, A. (författare)
Department of Organic Chemistry, Federico II Naples University, Naples, Italy, Department of Physiology, Valencia University, Valencia, Spain
Malorni, W. (författare)
Italian Natl. Inst. of Hlth. (ISS), Rome, Italy
Manini, P. (författare)
Department of Organic Chemistry, Federico II Naples University, Naples, Italy, Department of Physiology, Valencia University, Valencia, Spain
Masella, R. (författare)
Italian Natl. Inst. of Hlth. (ISS), Rome, Italy
Nobili, B. (författare)
Department of Paediatrics, 2nd Naples University, Naples, Italy
Pallardo, F.V. (författare)
Pallardó, F.V., Department of Organic Chemistry, Federico II Naples University, Naples, Italy, Department of Physiology, Valencia University, Valencia, Spain
Schweiger, M. (författare)
Department of Biochemistry, Free University Berlin, Berlin, Germany
Vuttariello, E. (författare)
Italian National Cancer Institute, Genoa, Italy
Youssoufian, G. (författare)
John Whiterspoon Middle School, Princeton, NJ, United States
Zatterale, A. (författare)
Department of Genetics, Elena d'Aosta Hospital, Naples, Italy
visa färre...
Italian National Cancer Institute, G Pascale Foundation, Paediatric Oncology Research Centre, Mercogliano (AV), Italy, Istituto Nazionale Tumori, Fondazione G. Pascale, v. M. Semmola, I-80131 Naples, Italy Clinical Discovery, Bristol-Myers Squibb Company, Princeton, NJ, United States (creator_code:org_t)
2003-05-19
2003
Engelska.
Ingår i: Bioessays. - : Wiley. - 0265-9247 .- 1521-1878. ; 25:6, s. 589-595
Relaterad länk:
https://urn.kb.se/re...
visa fler...
https://doi.org/10.1...
visa färre...
  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
Stäng  
  • Fanconi anaemia (FA) is a cancer-prone genetic disorder that is characterised by cytogenetic instability and redox abnormalities. Although rare subtypes of FA (B, D1 and D2) have been implicated in DNA repair through links with BRCA1 and BRCA2, such a role has yet to be demonstrated for gene products of the common subtypes. Instead, these products have been strongly implicated in xenobiotic metabolism and redox homeostasis through interactions of FANCC with cytochrome P-450 reductase and with glutathione S-transferase, and of FANCG with cytochrome P-450 2E1, as well as redox-dependent signalling through an interaction between FANCA and Akt kinase. We hypothesise that FA proteins act directly (via FANCC and FANCG) and indirectly (via FANCA, BRCA2 and FANCD2) with the machinery of cellular defence to modulate oxidative stress. The latter interactions may co-ordinate the link between the response to DNA damage and oxidative stress parameters (3, 6-12). © 2003 Wiley Periodicals, Inc.

Nyckelord

MEDICINE
MEDICIN

Publikations- och innehållstyp

ref (ämneskategori)
for (ämneskategori)

Hitta via bibliotek

  • Bioessays (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy