Mononuclear metal (II) complexes of a Bis(organoamido) phosphate ligand with antimicrobial activities against Escherichia coli

• A new tripodal ligand [PO((NHMePy)-Me-2)(3)] (L) ((MePy)-Me-2 = 2-(4-methyl pyridyl)) have been synthesized by treating phosphorous oxychloride with 2-Amino-4-methylpyridine in toluene under refluxing condition. The ligand was appeared as a white solid and characterized by several standard analytical and spectroscopic techniques such as FT-IR, NMR (H-1, C-13{H-1} and P-31{H-1}) and ESI-MS spectroscopy. The ligand (L) undergone metal-assisted hydrolysis of one P-N bond when treated it with hydrated metal nitrates, M(NO3)(2)center dot xH(2)O (M = Zn, Cu, Co and Ni) under hydrothermal reaction condition in DMF-H2O (1:1). This results in the formation of four mononuclear complexes [{PO2((NHMePy)-Me-2)(2)}(2)M] [M = Zn (1), Cu (2), Co (3), Ni (4)], where ligand (L) hydrolyses to a anionic bis(organoamido)phosphate, [PO2((NHMePy)-Me-2)(2)](-). All complexes were completely characterized by various analytical techniques and their solid state molecular structures were established by single crystal X-ray diffraction. All complexes are isostructural with a metal (II) ion situating at the centre of a distorted octahedron. Two tridentate [PO2((NHMePy)-Me-2)(2)](-) ligands are coordinated to metal(II) ion through N- and O-donor atoms, thus neutralizing the charge of the complex. Optical properties of all complexes in solid state have been studied. Moreover, antimicrobial activities of complexes 1-4 have been explored. To the best of our knowledge, this is the first report of such compounds investigated for their antimicrobial activities.

Ämnesord

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Nyckelord

antimicrobial activity

bis(organoamido)phosphate ligand

mononuclear metal complex

P-N bond hydrolysis

X-ray diffraction

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ref (ämneskategori)

art (ämneskategori)