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Träfflista för sökning "WFRF:(Palmer R) srt2:(1995-1999)"

Sökning: WFRF:(Palmer R) > (1995-1999)

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  • Lernmark, Å, et al. (författare)
  • Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus
  • 1995
  • Ingår i: Virchows Archiv. - 0945-6317. ; 425:6, s. 631-640
  • Tidskriftsartikel (refereegranskat)abstract
    • The mechanisms by which the beta cells of pancreatic islets are destroyed in insulin-dependent diabetes mellitus (IDDM) are poorly understood. In this report the pancreatic histo- and immunopathology of two children, both HLA-DR 3/4, DQ 2/8 positive and who both died from cerebral oedema within a day of clinical diagnosis of IDDM, were investigated. Patient 1, a 14-month-old girl, had a 4-week history of polydipsia and polyuria. Patient 2, a 3-year-old boy, had 2 days of illness. Both patients had a similarly severe loss of insulin cells but differed markedly as to the extent of lymphocytic islet infiltration (insulitis). Apart from insulitis, marked islet macrophage infiltration was demonstrated in both patients with the HAM-56 monoclonal antibody. Neither patient showed aberrant expression of HLA class II antigens on insulin-immunoreactive cells, but allele-specific HLA-DQ8 expression was evident on endothelial cells. Glutamic acid decarboxylase immunoreactivity was detected in both insulin- and glucagon-immunoreactive cells. It is concluded that the heterogeneity of islet pathology, especially insulitis, may reflect different dynamics and extent rather than different pathomechanisms of immune destruction of islets in IDDM.
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  • Palmer, K, et al. (författare)
  • Carmeda surface heparinization in neonatal ECMO systems: long-term experiments in a sheep model
  • 1995
  • Ingår i: Perfusion. - : SAGE Publications. - 0267-6591 .- 1477-111X. ; 10:5, s. 307-13
  • Tidskriftsartikel (refereegranskat)abstract
    • The thromboresistance in three Carmeda (Stockholm, Sweden) heparin- coated neonatal ECMO systems with a runtime of 45, 56 and 96 hours, respectively, and three noncoated systems with a runtime of 12, 42 and 66 hours, respectively, were compared using a sheep model. The flow rate was 200 ml/min and the activated clotting time (ACT) was kept at approximately 120 seconds. At the end of the experiment, the heparin-coated systems only contained minimal clotting while the controls showed major clotting in the entire system. Fibrin monomers were not detected until after 24 hours in the heparin- coated group, but demonstrated within 60 minutes in the noncoated group. It is concluded that the Carmeda heparin coating has a thromboresistant effect, and may be used to reduce the need for systemic heparinization in ECMO treatment of neonates.
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