| 1. |
- Barausse, Enrico, et al.
(författare)
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Prospects for fundamental physics with LISA
- 2020
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Ingår i: General Relativity and Gravitation. - : SPRINGER/PLENUM PUBLISHERS. - 0001-7701 .- 1572-9532. ; 52:8
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics. Given the very broad range of topics that might be relevant to LISA,we present here a sample of what we view as particularly promising fundamental physics directions. We organize these directions through a "science-first" approach that allows us to classify how LISA data can inform theoretical physics in a variety of areas. For each of these theoretical physics classes, we identify the sources that are currently expected to provide the principal contribution to our knowledge, and the areas that need further development. The classification presented here should not be thought of as cast in stone, but rather as a fluid framework that is amenable to change with the flow of new insights in theoretical physics.
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| 2. |
- Arun, K. G., et al.
(författare)
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New horizons for fundamental physics with LISA
- 2022
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Ingår i: Living Reviews in Relativity. - : Springer Science and Business Media LLC. - 1433-8351 .- 2367-3613. ; 25:1
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Forskningsöversikt (refereegranskat)abstract
- The Laser Interferometer Space Antenna (LISA) has the potential to reveal wonders about the fundamental theory of nature at play in the extreme gravity regime, where the gravitational interaction is both strong and dynamical. In this white paper, the Fundamental Physics Working Group of the LISA Consortium summarizes the current topics in fundamental physics where LISA observations of gravitational waves can be expected to provide key input. We provide the briefest of reviews to then delineate avenues for future research directions and to discuss connections between this working group, other working groups and the consortium work package teams. These connections must be developed for LISA to live up to its science potential in these areas.
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| 3. |
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| 4. |
- Chen, Zheng, 1990-, et al.
(författare)
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Optimizing Information Freshness in a Multiple Access Channel With Heterogeneous Devices
- 2021
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Ingår i: IEEE Open Journal of the Communications Society. - : IEEE. - 2644-125X. ; 2, s. 456-470
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Tidskriftsartikel (refereegranskat)abstract
- In this work, we study age-optimal scheduling with stability constraints in a multiple access channel with two heterogeneous source nodes transmitting to a common destination. The first node is connected to a power grid and it has randomly arriving data packets. Another energy harvesting (EH) sensor monitors a stochastic process and sends status updates to the destination. We formulate an optimization problem that aims at minimizing the average age of information (AoI) of the EH node subject to the queue stability condition of the grid-connected node. First, we consider a Probabilistic Random Access (PRA) policy where both nodes make independent transmission decisions based on some fixed probability distributions. We show that with this policy, the average AoI is equal to the average peak AoI, if the EH node only sends freshly generated samples. In addition, we derive the optimal solution in closed form, which reveals some interesting properties of the considered system. Furthermore, we consider a Drift-Plus-Penalty (DPP) policy and develop AoI-optimal and peak-AoI-optimal scheduling algorithms using the Lyapunov optimization theory. Simulation results show that the DPP policy outperforms the PRA policy in various scenarios, especially when the destination node has low multi-packet reception capabilities.
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| 5. |
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| 6. |
- Gomez-Cabello, D, et al.
(författare)
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CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway
- 2022
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 5303-
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Tidskriftsartikel (refereegranskat)abstract
- The RNA world is changing our views about sensing and resolution of DNA damage. Here, we develop single-molecule DNA/RNA analysis approaches to visualize how nascent RNA facilitates the repair of DNA double-strand breaks (DSBs). RNA polymerase II (RNAPII) is crucial for DSB resolution in human cells. DSB-flanking, RNAPII-generated nascent RNA forms RNA:DNA hybrids, guiding the upstream DNA repair steps towards favouring the error-free Homologous Recombination (HR) pathway over Non-Homologous End Joining. Specific RNAPII inhibitor, THZ1, impairs recruitment of essential HR proteins to DSBs, implicating nascent RNA in DNA end resection, initiation and execution of HR repair. We further propose that resection factor CtIP interacts with and helps re-activate RNAPII when paused by the RNA:DNA hybrids, collectively promoting faithful repair of chromosome breaks to maintain genomic integrity.
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| 7. |
- Heil, J., et al.
(författare)
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Preoperative portal vein or portal and hepatic vein embolization: DRAGON collaborative group analysis
- 2021
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Ingår i: British Journal of Surgery. - : OXFORD UNIV PRESS. - 0007-1323 .- 1365-2168. ; 108:7, s. 834-842
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Tidskriftsartikel (refereegranskat)abstract
- Y Background: The extent of liver resection for tumours is limited by the expected functional reserve of the future liver remnant (FRL), so hypertrophy may be induced by portal vein embolization (PVE), taking 6 weeks or longer for growth. This study assessed the hypothesis that simultaneous embolization of portal and hepatic veins (PVE/HVE) accelerates hypertrophy and improves resectability. Methods: All centres of the international DRAGON trials study collaborative were asked to provide data on patients who had PVE/HVE or PVE on 2016-2019 (more than 5 PVE/HVE procedures was a requirement). Liver volumetry was performed using OsiriX MD software. Multivariable analysis was performed for the endpoints of resectability rate, FLR hypertrophy and major complications using receiver operating characteristic (ROC) statistics, regression, and Kaplan-Meier analysis. Results: In total, 39 patients had undergone PVE/HVE and 160 had PVE alone. The PVE/HVE group had better hypertrophy than the PVE group (59 versus 48 per cent respectively; P=0.020) and resectability (90 versus 68 per cent; P=0.007). Major complications (26 versus 34 per cent; P=0.550) and 90-day mortality (3 versus 16 per cent respectively, P = 0.065) were comparable. Multivariable analysis confirmed that these effects were independent of confounders. Conclusion: PVE/HVE achieved better FLR hypertrophy and resectability than PVE in this collaborative experience.
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| 8. |
- Larsen, BD, et al.
(författare)
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Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress
- 2022
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 376:6592, s. 476-
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Tidskriftsartikel (refereegranskat)abstract
- Genotoxic therapy such as radiation serves as a frontline cancer treatment, yet acquired resistance that leads to tumor reoccurrence is frequent. We found that cancer cells maintain viability during irradiation by reversibly increasing genome-wide DNA breaks, thereby limiting premature mitotic progression. We identify caspase-activated DNase (CAD) as the nuclease inflicting these de novo DNA lesions at defined loci, which are in proximity to chromatin-modifying CCCTC-binding factor (CTCF) sites. CAD nuclease activity is governed through phosphorylation by DNA damage response kinases, independent of caspase activity. In turn, loss of CAD activity impairs cell fate decisions, rendering cancer cells vulnerable to radiation-induced DNA double-strand breaks. Our observations highlight a cancer-selective survival adaptation, whereby tumor cells deploy regulated DNA breaks to delimit the detrimental effects of therapy-evoked DNA damage.
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| 9. |
- Lindemann, Lars, et al.
(författare)
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Control Barrier Functions for Nonholonomic Systems under Risk Signal Temporal Logic Specifications
- 2020
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Ingår i: Proceedings of the IEEE Conference on Decision and Control. - : Institute of Electrical and Electronics Engineers Inc.. ; , s. 1422-1428
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Konferensbidrag (refereegranskat)abstract
- Temporal logics provide a formalism for expressing complex system specifications. A large body of literature has addressed the verification and the control synthesis problem for deterministic systems under such specifications. For stochastic systems or systems operating in unknown environments, however, only the probability of satisfying a specification has been considered so far, neglecting the risk of not satisfying the specification. Towards addressing this shortcoming, we consider, for the first time, risk metrics, such as (but not limited to) the Conditional Value-at-Risk, and propose risk signal temporal logic. Specifically, we compose risk metrics with stochastic predicates to consider the risk of violating certain spatial specifications. As a particular instance of such stochasticity, we consider control systems in unknown environments and present a determinization of the risk signal temporal logic specification to transform the stochastic control problem into a deterministic one. For unicycle-like dynamics, we then extend our previous work on deterministic time-varying control barrier functions.
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| 10. |
- Lindemann, L., et al.
(författare)
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Reactive and Risk-Aware Control for Signal Temporal Logic
- 2021
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Ingår i: IEEE Transactions on Automatic Control. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9286 .- 1558-2523.
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Tidskriftsartikel (refereegranskat)abstract
- The deployment of autonomous systems in uncertain and dynamic environments has raised fundamental questions. Addressing these is pivotal to build fully autonomous systems and requires a systematic integration of planning and control. We first propose reactive risk signal interval temporal logic (ReRiSITL) as an extension of signal temporal logic (STL) to formulate complex spatiotemporal specifications. Unlike STL, ReRiSITL allows to consider uncontrollable propositions that may model humans as well as random environmental events such as sensor failures. Additionally, ReRiSITL allows to incorporate risk measures, such as (but not limited to) the Conditional Value-at-Risk, to measure the risk of violating certain spatial specifications. Second, we propose an algorithm to check if an ReRiSITL specification is satisfiable. For this purpose, we abstract the ReRiSITL specification into a timed signal transducer and devise a game-based approach. Third, we propose a reactive planning and control framework for dynamical control systems under ReRiSITL specifications.
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